DegronMD

Uniprot ID: Q9UPA5

Source protein: Protein bassoon

Source gene: BSN

Class: DEG_SCF_FBW7_1

Location: 1307:1313

E3 ligase: FBXW7

DEGRON score: 0.9627

ASA_SCORE: 87.1714

COIL: 0.9577

CONS_SCORE: 1

DSS_SCORE: 0.6992

HELIX: 0.0104

FCONS_SCORE: 1.024

RIG_SCORE: 0.5916

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1318V	TCGA-D3-A8GM	SKCM	TCGA	PLTPGTS	DEG_SCF_FBW7_1	0.1944
p.A1318V	DO50288	SKCM	ICGC	PLTPGTS	DEG_SCF_FBW7_1	0.1944
p.P1310S	TCGA-DA-A3F8	SKCM	TCGA	PLTPGTS	DEG_SCF_FBW7_1	0.6752
p.P1310S	DO37418	SKCM	ICGC	PLTPGTS	DEG_SCF_FBW7_1	0.6752
p.T1312I	TCGA-EE-A20H	SKCM	TCGA	PLTPGTS	DEG_SCF_FBW7_1	0.5966
p.T1312I	DO37986	SKCM	ICGC	PLTPGTS	DEG_SCF_FBW7_1	0.5966
p.P1307S	DO233935	GACA	ICGC	PLTPGTS	DEG_SCF_FBW7_1	0.6752
p.P1314H	SIDM00422	Hodgkin's Lymphoma	GDSC	PLTPGTS	DEG_SCF_FBW7_1	0.3056
p.P1314H	SUP-HD1	haematopoietic_and_lymphoid_tissue	COSMIC	PLTPGTS	DEG_SCF_FBW7_1	0.3056
p.S1322P	SIDM00217	Colorectal Carcinoma	GDSC	PLTPGTS	DEG_SCF_FBW7_1	0.0833
p.S1322P	ACH-000999	Colon/Colorectal Cancer	CCLE	PLTPGTS	DEG_SCF_FBW7_1	0.0833
p.S1322P	SNU-1040	large_intestine	COSMIC	PLTPGTS	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UPA5	Protein bassoon	DEG_SCF_FBW7_1	1307:1313	PLTPGTS	FBXW7	0.9627	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons