DegronMD

Uniprot ID: Q9UPA5

Source protein: Protein bassoon

Source gene: BSN

Class: DEG_COP1_1

Location: 3186:3197

E3 ligase: COP1

DEGRON score: 0.953

ASA_SCORE: 70.3167

COIL: 0.7992

CONS_SCORE: 0.8335

DSS_SCORE: 0.6164

HELIX: 0.0877

FCONS_SCORE: 1.0139

RIG_SCORE: 0.6385

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q3191H	TCGA-37-3789	LUSC	TCGA	SSGYEQGKVPEV	DEG_COP1_1	0.647
p.Q3191H	DO26743	LUSC	ICGC	SSGYEQGKVPEV	DEG_COP1_1	0.647
p.E3190Q	TCGA-AC-A23H	BRCA	TCGA	SSGYEQGKVPEV	DEG_COP1_1	0.6744
p.E3190Q	DO2401	BRCA	ICGC	SSGYEQGKVPEV	DEG_COP1_1	0.6744
p.R3203C	TCGA-AR-A0TZ	BRCA	TCGA	SSGYEQGKVPEV	DEG_COP1_1	0.1667
p.R3203C	DO2287	BRCA	ICGC	SSGYEQGKVPEV	DEG_COP1_1	0.1667
p.R3203C	DO52389	LUSC	ICGC	SSGYEQGKVPEV	DEG_COP1_1	0.1667
p.V3197M	DO8730	COAD	ICGC	SSGYEQGKVPEV	DEG_COP1_1	0.6097
p.G3182V	DO229029	LICA	ICGC	SSGYEQGKVPEV	DEG_COP1_1	0.2222
p.G3188S	DO229055	LICA	ICGC	SSGYEQGKVPEV	DEG_COP1_1	0.5882
p.G3201D	DO222843	MELA	ICGC	SSGYEQGKVPEV	DEG_COP1_1	0.2222
p.S3179G	SIDM00683	Prostate Carcinoma	GDSC	SSGYEQGKVPEV	DEG_COP1_1	0.1389
p.S3179G	LNCaP-Clone-FGC	prostate	COSMIC	SSGYEQGKVPEV	DEG_COP1_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UPA5	Protein bassoon	DEG_COP1_1	3186:3197	SSGYEQGKVPEV	COP1	0.953	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons