DegronMD

Uniprot ID: Q9UPA5

Source protein: Protein bassoon

Source gene: BSN

Class: DEG_SCF_FBW7_1

Location: 984:991

E3 ligase: FBXW7

DEGRON score: 0.9121

ASA_SCORE: 92.2125

COIL: 0.9511

CONS_SCORE: 0.6964

DSS_SCORE: 0.7381

HELIX: 0.0134

FCONS_SCORE: 1.0881

RIG_SCORE: 0.5534

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S992L	TCGA-BH-A0DD	BRCA	TCGA	PASTPSYT	DEG_SCF_FBW7_1	0.3056
p.S992L	DO2008	BRCA	ICGC	PASTPSYT	DEG_SCF_FBW7_1	0.3056
p.P996S	TCGA-EL-A4K4	THCA	TCGA	PASTPSYT	DEG_SCF_FBW7_1	0.1944
p.P996S	DO39546	THCA	ICGC	PASTPSYT	DEG_SCF_FBW7_1	0.1944
p.S992W	TCGA-MN-A4N5	LUAD	TCGA	PASTPSYT	DEG_SCF_FBW7_1	0.3056
p.S992W	DO45332	LUAD	ICGC	PASTPSYT	DEG_SCF_FBW7_1	0.3056
p.R974L	DO228948	LICA	ICGC	PASTPSYT	DEG_SCF_FBW7_1	0.0556
p.R976H	DO229257	THCA	ICGC	PASTPSYT	DEG_SCF_FBW7_1	0.1111
p.R976H	DO41056	UCEC	ICGC	PASTPSYT	DEG_SCF_FBW7_1	0.1111
p.S998Y	SIDM01612	Endometrial Carcinoma	GDSC	PASTPSYT	DEG_SCF_FBW7_1	0.1389
p.S998Y	ACH-000946	Endometrial/Uterine Cancer	CCLE	PASTPSYT	DEG_SCF_FBW7_1	0.1389
p.P996H	ACH-001367	Neuroblastoma	CCLE	PASTPSYT	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UPA5	Protein bassoon	DEG_SCF_FBW7_1	984:991	PASTPSYT	FBXW7	0.9121	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons