DegronMD

Uniprot ID: Q5VVP1

Source protein: Spermatogenesis-associated protein 31A6

Source gene: SPATA31A6

Class: DEG_Kelch_Keap1_1

Location: 642:647

E3 ligase: KEAP1

DEGRON score: 0.7284

ASA_SCORE: 77.0167

COIL: 0.8575

CONS_SCORE: 0.3114

DSS_SCORE: 0.7

HELIX: 0.0727

FCONS_SCORE: 0.8305

RIG_SCORE: 0.5676

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q653L	TCGA-44-7662	LUAD	TCGA	STSTGE	DEG_Kelch_Keap1_1	0.1667
p.Q653L	TCGA-L4-A4E5	LUAD	TCGA	STSTGE	DEG_Kelch_Keap1_1	0.1667
p.Q653L	DO24320	LUAD	ICGC	STSTGE	DEG_Kelch_Keap1_1	0.1667
p.Q653L	DO23597	LUAD	ICGC	STSTGE	DEG_Kelch_Keap1_1	0.1667
p.K656T	TCGA-BR-8588	STAD	TCGA	STSTGE	DEG_Kelch_Keap1_1	0.1944
p.K656T	TCGA-VQ-AA68	STAD	TCGA	STSTGE	DEG_Kelch_Keap1_1	0.1944
p.K656T	DO234461	ESAD	ICGC	STSTGE	DEG_Kelch_Keap1_1	0.1944
p.K656T	DO51799	STAD	ICGC	STSTGE	DEG_Kelch_Keap1_1	0.1944
p.K656T	DO47855	STAD	ICGC	STSTGE	DEG_Kelch_Keap1_1	0.1944
p.F657V	TCGA-L5-A8NW	ESCA	TCGA	STSTGE	DEG_Kelch_Keap1_1	0.0556
p.Q640L	TCGA-OR-A5KB	ACC	TCGA	STSTGE	DEG_Kelch_Keap1_1	0.2778
p.S637I	DO228856	LICA	ICGC	STSTGE	DEG_Kelch_Keap1_1	0.1944
p.T643M	DO224551	LUSC	ICGC	STSTGE	DEG_Kelch_Keap1_1	0.6312
p.K650N	SIDM01002	Breast Carcinoma	GDSC	STSTGE	DEG_Kelch_Keap1_1	0.3611
p.F657L	ACH-000986	Colon/Colorectal Cancer	CCLE	STSTGE	DEG_Kelch_Keap1_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P33991	DNA replication licensing factor MCM4	DEG_Kelch_Keap1_1	42:47	STSTGE	KEAP1	0.977	More...
Q5VVP1	Spermatogenesis-associated protein 31A6	DEG_Kelch_Keap1_1	642:647	STSTGE	KEAP1	0.7284	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons