DegronMD

Uniprot ID: P33991

Source protein: DNA replication licensing factor MCM4

Source gene: MCM4

Class: DEG_Kelch_Keap1_1

Location: 42:47

E3 ligase: KEAP1

DEGRON score: 0.977

ASA_SCORE: 81.9

COIL: 0.9107

CONS_SCORE: 0.2581

DSS_SCORE: 0.8791

HELIX: 0.0552

FCONS_SCORE: 0.9561

RIG_SCORE: 0.5379

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G39D	TCGA-2W-A8YY	CESC	TCGA	STSTGE	DEG_Kelch_Keap1_1	0.25
p.G39D	DO223732	CESC	ICGC	STSTGE	DEG_Kelch_Keap1_1	0.25
p.E40K	TCGA-95-8494	LUAD	TCGA	STSTGE	DEG_Kelch_Keap1_1	0.2778
p.E40K	DO51198	LUAD	ICGC	STSTGE	DEG_Kelch_Keap1_1	0.2778
p.S32C	TCGA-BT-A20U	BLCA	TCGA	STSTGE	DEG_Kelch_Keap1_1	0.5
p.S32C	DO538	BLCA	ICGC	STSTGE	DEG_Kelch_Keap1_1	0.5
p.S32C	DO225215	BRCA	ICGC	STSTGE	DEG_Kelch_Keap1_1	0.5
p.S32C	DO227836	BRCA	ICGC	STSTGE	DEG_Kelch_Keap1_1	0.5
p.T43N	TCGA-D1-A103	UCEC	TCGA	STSTGE	DEG_Kelch_Keap1_1	0.5944
p.T43N	DO42312	UCEC	ICGC	STSTGE	DEG_Kelch_Keap1_1	0.5944
p.P33L	TCGA-EE-A2GM	SKCM	TCGA	STSTGE	DEG_Kelch_Keap1_1	0.0833
p.P33L	DO37555	SKCM	ICGC	STSTGE	DEG_Kelch_Keap1_1	0.0833
p.S54L	TCGA-EE-A2MR	SKCM	TCGA	STSTGE	DEG_Kelch_Keap1_1	0.5833
p.S54L	DO37819	SKCM	ICGC	STSTGE	DEG_Kelch_Keap1_1	0.5833
p.D41G	DO227745	COCA	ICGC	STSTGE	DEG_Kelch_Keap1_1	0.3056
p.R38I	DO228614	GACA	ICGC	STSTGE	DEG_Kelch_Keap1_1	0.2222
p.S34C	DO230529	LUSC	ICGC	STSTGE	DEG_Kelch_Keap1_1	0.5556
p.R36K	DO220886	MELA	ICGC	STSTGE	DEG_Kelch_Keap1_1	0.1667
p.P50S	SIDM00783	Colorectal Carcinoma	GDSC	STSTGE	DEG_Kelch_Keap1_1	0.25
p.P50S	ACH-000971	Colon/Colorectal Cancer	CCLE	STSTGE	DEG_Kelch_Keap1_1	0.25
p.R37H	ACH-000764	Gastric Cancer	CCLE	STSTGE	DEG_Kelch_Keap1_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P33991	DNA replication licensing factor MCM4	DEG_Kelch_Keap1_1	42:47	STSTGE	KEAP1	0.977	More...
Q5VVP1	Spermatogenesis-associated protein 31A6	DEG_Kelch_Keap1_1	642:647	STSTGE	KEAP1	0.7284	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons