DegronMD - P33991(MCM4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G39D	TCGA-2W-A8YY	CESC	TCGA	STSTGE	DEG_Kelch_Keap1_1	42:47	Mutation rewiring degron network	0.25
p.G39D	DO223732	CESC	ICGC	STSTGE	DEG_Kelch_Keap1_1	42:47	Mutation rewiring degron network	0.25
p.A29S	TCGA-56-8626	LUSC	TCGA	PAQTPRSE	DEG_SCF_FBW7_2	20:27	Mutation rewiring degron network	0.2778
p.A29S	DO45506	LUSC	ICGC	PAQTPRSE	DEG_SCF_FBW7_2	20:27	Mutation rewiring degron network	0.2778
p.A29D	TCGA-77-7337	LUSC	TCGA	PAQTPRSE	DEG_SCF_FBW7_2	20:27	Mutation rewiring degron network	0.2778
p.A29D	DO27445	LUSC	ICGC	PAQTPRSE	DEG_SCF_FBW7_2	20:27	Mutation rewiring degron network	0.2778
p.E40K	TCGA-95-8494	LUAD	TCGA	STSTGE	DEG_Kelch_Keap1_1	42:47	Mutation rewiring degron network	0.2778
p.E40K	DO51198	LUAD	ICGC	STSTGE	DEG_Kelch_Keap1_1	42:47	Mutation rewiring degron network	0.2778
p.S32C	TCGA-BT-A20U	BLCA	TCGA	STSTGE	DEG_Kelch_Keap1_1	42:47	Mutation blocking phosphorylation signal	0.5
p.S32C	TCGA-BT-A20U	BLCA	TCGA	PAQTPRSE	DEG_SCF_FBW7_2	20:27	Mutation blocking phosphorylation signal	0.6389
p.S32C	DO538	BLCA	ICGC	STSTGE	DEG_Kelch_Keap1_1	42:47	Mutation blocking phosphorylation signal	0.5
p.S32C	DO538	BLCA	ICGC	PAQTPRSE	DEG_SCF_FBW7_2	20:27	Mutation blocking phosphorylation signal	0.6389
p.S32C	DO225215	BRCA	ICGC	STSTGE	DEG_Kelch_Keap1_1	42:47	Mutation blocking phosphorylation signal	0.5
p.S32C	DO225215	BRCA	ICGC	PAQTPRSE	DEG_SCF_FBW7_2	20:27	Mutation blocking phosphorylation signal	0.6389
p.S32C	DO227836	BRCA	ICGC	STSTGE	DEG_Kelch_Keap1_1	42:47	Mutation blocking phosphorylation signal	0.5
p.S32C	DO227836	BRCA	ICGC	PAQTPRSE	DEG_SCF_FBW7_2	20:27	Mutation blocking phosphorylation signal	0.6389
p.T43N	TCGA-D1-A103	UCEC	TCGA	STSTGE	DEG_Kelch_Keap1_1	42:47	Mutation altering degron motif	0.5944
p.T43N	DO42312	UCEC	ICGC	STSTGE	DEG_Kelch_Keap1_1	42:47	Mutation altering degron motif	0.5944
p.R25W	TCGA-DK-A3IN	BLCA	TCGA	PAQTPRSE	DEG_SCF_FBW7_2	20:27	Mutation altering degron motif	0.7523
p.R25W	DO455	BLCA	ICGC	PAQTPRSE	DEG_SCF_FBW7_2	20:27	Mutation altering degron motif	0.7523
p.P33L	TCGA-EE-A2GM	SKCM	TCGA	STSTGE	DEG_Kelch_Keap1_1	42:47	Mutation rewiring degron network	0.0833
p.P33L	TCGA-EE-A2GM	SKCM	TCGA	PAQTPRSE	DEG_SCF_FBW7_2	20:27	Mutation rewiring degron network	0.1667
p.P33L	DO37555	SKCM	ICGC	STSTGE	DEG_Kelch_Keap1_1	42:47	Mutation rewiring degron network	0.0833
p.P33L	DO37555	SKCM	ICGC	PAQTPRSE	DEG_SCF_FBW7_2	20:27	Mutation rewiring degron network	0.1667
p.S54L	TCGA-EE-A2MR	SKCM	TCGA	STSTGE	DEG_Kelch_Keap1_1	42:47	Mutation blocking phosphorylation signal	0.5833
p.S54L	DO37819	SKCM	ICGC	STSTGE	DEG_Kelch_Keap1_1	42:47	Mutation blocking phosphorylation signal	0.5833
p.D41G	DO227745	COCA	ICGC	STSTGE	DEG_Kelch_Keap1_1	42:47	Mutation rewiring degron network	0.3056
p.R38I	DO228614	GACA	ICGC	STSTGE	DEG_Kelch_Keap1_1	42:47	Mutation rewiring degron network	0.2222
p.S34C	DO230529	LUSC	ICGC	STSTGE	DEG_Kelch_Keap1_1	42:47	Mutation blocking phosphorylation signal	0.5556
p.S34C	DO230529	LUSC	ICGC	PAQTPRSE	DEG_SCF_FBW7_2	20:27	Mutation blocking phosphorylation signal	0.5833
p.R36K	DO220886	MELA	ICGC	STSTGE	DEG_Kelch_Keap1_1	42:47	Mutation rewiring degron network	0.1667
p.R36K	DO220886	MELA	ICGC	PAQTPRSE	DEG_SCF_FBW7_2	20:27	Mutation rewiring degron network	0.0833
p.D28Y	SIDM00424	B-Cell Non-Hodgkin's Lymphoma	GDSC	PAQTPRSE	DEG_SCF_FBW7_2	20:27	Mutation rewiring degron network	0.3056
p.D28Y	ACH-001680	Lymphoma	CCLE	PAQTPRSE	DEG_SCF_FBW7_2	20:27	Mutation rewiring degron network	0.3056
p.D28Y	U-698-M	haematopoietic and lymphoid tissue	COSMIC	PAQTPRSE	DEG_SCF_FBW7_2	20:27	Mutation rewiring degron network	0.3056
p.P50S	SIDM00783	Colorectal Carcinoma	GDSC	STSTGE	DEG_Kelch_Keap1_1	42:47	Mutation rewiring degron network	0.25
p.P50S	ACH-000971	Colon/Colorectal Cancer	CCLE	STSTGE	DEG_Kelch_Keap1_1	42:47	Mutation rewiring degron network	0.25
p.E27D	SIDM01608	Endometrial Carcinoma	GDSC	PAQTPRSE	DEG_SCF_FBW7_2	20:27	Mutation altering degron motif	0.6758
p.E27D	ACH-000990	Endometrial/Uterine Cancer	CCLE	PAQTPRSE	DEG_SCF_FBW7_2	20:27	Mutation altering degron motif	0.6758
p.G16E	ACH-000678	Gastric Cancer	CCLE	PAQTPRSE	DEG_SCF_FBW7_2	20:27	Mutation rewiring degron network	0.2222
p.R37H	ACH-000764	Gastric Cancer	CCLE	STSTGE	DEG_Kelch_Keap1_1	42:47	Mutation rewiring degron network	0.1944
p.R37H	ACH-000764	Gastric Cancer	CCLE	PAQTPRSE	DEG_SCF_FBW7_2	20:27	Mutation rewiring degron network	0.0556
p.A21V	ACH-000971	Colon/Colorectal Cancer	CCLE	PAQTPRSE	DEG_SCF_FBW7_2	20:27	Mutation altering degron motif	0.5825

Kaplan plot for MCM4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MCM4

UniProt ID: P33991

Entrez ID: 4173

Protein name: DNA replication licensing factor MCM4 (EC 3.6.4.12) (CDC21 homolog) (P1-CDC21)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MCM4 in