DegronMD

Uniprot ID: P33991

Source protein: DNA replication licensing factor MCM4

Source gene: MCM4

Class: DEG_SCF_FBW7_2

Location: 20:27

E3 ligase: FBXW7

DEGRON score: 0.8819

ASA_SCORE: 102.4125

COIL: 0.8959

CONS_SCORE: 0.2357

DSS_SCORE: 0.9009

HELIX: 0.0889

FCONS_SCORE: 0.9794

RIG_SCORE: 0.5587

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A29S	TCGA-56-8626	LUSC	TCGA	PAQTPRSE	DEG_SCF_FBW7_2	0.2778
p.A29S	DO45506	LUSC	ICGC	PAQTPRSE	DEG_SCF_FBW7_2	0.2778
p.A29D	TCGA-77-7337	LUSC	TCGA	PAQTPRSE	DEG_SCF_FBW7_2	0.2778
p.A29D	DO27445	LUSC	ICGC	PAQTPRSE	DEG_SCF_FBW7_2	0.2778
p.S32C	TCGA-BT-A20U	BLCA	TCGA	PAQTPRSE	DEG_SCF_FBW7_2	0.6389
p.S32C	DO538	BLCA	ICGC	PAQTPRSE	DEG_SCF_FBW7_2	0.6389
p.S32C	DO225215	BRCA	ICGC	PAQTPRSE	DEG_SCF_FBW7_2	0.6389
p.S32C	DO227836	BRCA	ICGC	PAQTPRSE	DEG_SCF_FBW7_2	0.6389
p.R25W	TCGA-DK-A3IN	BLCA	TCGA	PAQTPRSE	DEG_SCF_FBW7_2	0.7523
p.R25W	DO455	BLCA	ICGC	PAQTPRSE	DEG_SCF_FBW7_2	0.7523
p.P33L	TCGA-EE-A2GM	SKCM	TCGA	PAQTPRSE	DEG_SCF_FBW7_2	0.1667
p.P33L	DO37555	SKCM	ICGC	PAQTPRSE	DEG_SCF_FBW7_2	0.1667
p.S34C	DO230529	LUSC	ICGC	PAQTPRSE	DEG_SCF_FBW7_2	0.5833
p.R36K	DO220886	MELA	ICGC	PAQTPRSE	DEG_SCF_FBW7_2	0.0833
p.D28Y	SIDM00424	B-Cell Non-Hodgkin's Lymphoma	GDSC	PAQTPRSE	DEG_SCF_FBW7_2	0.3056
p.D28Y	ACH-001680	Lymphoma	CCLE	PAQTPRSE	DEG_SCF_FBW7_2	0.3056
p.D28Y	U-698-M	haematopoietic_and_lymphoid_tissue	COSMIC	PAQTPRSE	DEG_SCF_FBW7_2	0.3056
p.E27D	SIDM01608	Endometrial Carcinoma	GDSC	PAQTPRSE	DEG_SCF_FBW7_2	0.6758
p.E27D	ACH-000990	Endometrial/Uterine Cancer	CCLE	PAQTPRSE	DEG_SCF_FBW7_2	0.6758
p.G16E	ACH-000678	Gastric Cancer	CCLE	PAQTPRSE	DEG_SCF_FBW7_2	0.2222
p.R37H	ACH-000764	Gastric Cancer	CCLE	PAQTPRSE	DEG_SCF_FBW7_2	0.0556
p.A21V	ACH-000971	Colon/Colorectal Cancer	CCLE	PAQTPRSE	DEG_SCF_FBW7_2	0.5825

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P33991	DNA replication licensing factor MCM4	DEG_SCF_FBW7_2	20:27	PAQTPRSE	FBXW7	0.8819	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons