DegronMD

Uniprot ID: Q8NEM0

Source protein: Microcephalin

Source gene: MCPH1

Class: DEG_SCF_FBW7_2

Location: 160:167

E3 ligase: FBXW7

DEGRON score: 0.9245

ASA_SCORE: 81.4875

COIL: 0.7708

CONS_SCORE: 0.4409

DSS_SCORE: 0.3377

HELIX: 0.0465

FCONS_SCORE: 1.034

RIG_SCORE: 0.7671

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S174T	TCGA-55-8620	LUAD	TCGA	LIYTPTIE	DEG_SCF_FBW7_2	0.1389
p.S174T	DO24547	LUAD	ICGC	LIYTPTIE	DEG_SCF_FBW7_2	0.1389
p.T163I	TCGA-A5-A0G2	UCEC	TCGA	LIYTPTIE	DEG_SCF_FBW7_2	0.7078
p.T163I	DO41235	UCEC	ICGC	LIYTPTIE	DEG_SCF_FBW7_2	0.7078
p.N169H	TCGA-AA-3984	COAD	TCGA	LIYTPTIE	DEG_SCF_FBW7_2	0.2778
p.N169H	DO9002	COAD	ICGC	LIYTPTIE	DEG_SCF_FBW7_2	0.2778
p.F154I	TCGA-D1-A16X	UCEC	TCGA	LIYTPTIE	DEG_SCF_FBW7_2	0.1667
p.F154I	DO41799	UCEC	ICGC	LIYTPTIE	DEG_SCF_FBW7_2	0.1667
p.L166F	DO225307	BRCA	ICGC	LIYTPTIE	DEG_SCF_FBW7_2	0.6981
p.R170H	DO49095	COAD	ICGC	LIYTPTIE	DEG_SCF_FBW7_2	0.25
p.R170H	DO51761	STAD	ICGC	LIYTPTIE	DEG_SCF_FBW7_2	0.25
p.R171S	DO229010	COCA	ICGC	LIYTPTIE	DEG_SCF_FBW7_2	0.2222
p.R171S	DO229013	COCA	ICGC	LIYTPTIE	DEG_SCF_FBW7_2	0.2222
p.R171S	DO229016	COCA	ICGC	LIYTPTIE	DEG_SCF_FBW7_2	0.2222
p.R171S	DO229003	COCA	ICGC	LIYTPTIE	DEG_SCF_FBW7_2	0.2222
p.R171S	DO229005	COCA	ICGC	LIYTPTIE	DEG_SCF_FBW7_2	0.2222
p.T165A	DO233930	GACA	ICGC	LIYTPTIE	DEG_SCF_FBW7_2	0.6028
p.D176G	DO44443	HNSC	ICGC	LIYTPTIE	DEG_SCF_FBW7_2	0.0833
p.I168T	DO229480	LAML	ICGC	LIYTPTIE	DEG_SCF_FBW7_2	0.3056
p.M176I	DO229038	LICA	ICGC	LIYTPTIE	DEG_SCF_FBW7_2	0.0833
p.D171N	DO230961	LUSC	ICGC	LIYTPTIE	DEG_SCF_FBW7_2	0.2222
p.D171N	DO224594	LUSC	ICGC	LIYTPTIE	DEG_SCF_FBW7_2	0.2222
p.N156H	DO26434	LUSC	ICGC	LIYTPTIE	DEG_SCF_FBW7_2	0.2222
p.Q151R	DO223719	LUSC	ICGC	LIYTPTIE	DEG_SCF_FBW7_2	0.0833
p.Q151R	DO47981	STAD	ICGC	LIYTPTIE	DEG_SCF_FBW7_2	0.0833
p.Q151R	ROS-50	haematopoietic_and_lymphoid_tissue	COSMIC	LIYTPTIE	DEG_SCF_FBW7_2	0.0833
p.P165L	DO222363	MELA	ICGC	LIYTPTIE	DEG_SCF_FBW7_2	0.7582
p.P165S	DO222875	MELA	ICGC	LIYTPTIE	DEG_SCF_FBW7_2	0.6752
p.Y162N	DO233292	NACA	ICGC	LIYTPTIE	DEG_SCF_FBW7_2	0.5948
p.P150L	DO46396	OV	ICGC	LIYTPTIE	DEG_SCF_FBW7_2	0.0556
p.D176A	DO35242	PACA	ICGC	LIYTPTIE	DEG_SCF_FBW7_2	0.0833
p.P157Q	DO37631	SKCM	ICGC	LIYTPTIE	DEG_SCF_FBW7_2	0.25
p.D176Y	DO37921	SKCM	ICGC	LIYTPTIE	DEG_SCF_FBW7_2	0.0833
p.H154N	DO47636	SKCM	ICGC	LIYTPTIE	DEG_SCF_FBW7_2	0.1667
p.S174R	DO229240	THCA	ICGC	LIYTPTIE	DEG_SCF_FBW7_2	0.1389
p.I168S	DO41235	UCEC	ICGC	LIYTPTIE	DEG_SCF_FBW7_2	0.3056
p.I168V	ACH-002014	Eye Cancer	CCLE	LIYTPTIE	DEG_SCF_FBW7_2	0.3056
p.I168V	ACH-002018	Eye Cancer	CCLE	LIYTPTIE	DEG_SCF_FBW7_2	0.3056
p.T172A	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	LIYTPTIE	DEG_SCF_FBW7_2	0.1944
p.T172I	NCI-H1155	lung	COSMIC	LIYTPTIE	DEG_SCF_FBW7_2	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LIYTPTIE

Degron related mutations and impact score

Drug responses associated with MCPH1 mutations

All proteins holding degron of LIYTPTIE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NEM0	Microcephalin	DEG_SCF_FBW7_2	160:167	LIYTPTIE	FBXW7	0.9245	More...