DegronMD

Uniprot ID: Q8NEM0

Source protein: Microcephalin

Source gene: MCPH1

Class: DEG_SPOP_SBC_1

Location: 349:353

E3 ligase: SPOP

DEGRON score: 0.9918

ASA_SCORE: 102.9

COIL: 0.889

CONS_SCORE: 0.4407

DSS_SCORE: 0.7037

HELIX: 0.102

FCONS_SCORE: 1.0646

RIG_SCORE: 0.5894

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R358I	TCGA-AA-3977	COAD	TCGA	PRSSS	DEG_SPOP_SBC_1	0.1944
p.L343I	TCGA-FI-A2D5	UCEC	TCGA	PRSSS	DEG_SPOP_SBC_1	0.1667
p.S352F	TCGA-GF-A6C9	SKCM	TCGA	PRSSS	DEG_SPOP_SBC_1	0.7982
p.R350M	TCGA-IB-7651	PAAD	TCGA	PRSSS	DEG_SPOP_SBC_1	0.7521
p.A350V	DO229378	BTCA	ICGC	PRSSS	DEG_SPOP_SBC_1	0.6936
p.D344G	DO229010	COCA	ICGC	PRSSS	DEG_SPOP_SBC_1	0.1944
p.D344G	DO229013	COCA	ICGC	PRSSS	DEG_SPOP_SBC_1	0.1944
p.D344G	DO229016	COCA	ICGC	PRSSS	DEG_SPOP_SBC_1	0.1944
p.D344G	DO229003	COCA	ICGC	PRSSS	DEG_SPOP_SBC_1	0.1944
p.D344G	DO229005	COCA	ICGC	PRSSS	DEG_SPOP_SBC_1	0.1944
p.C359F	DO45069	LINC	ICGC	PRSSS	DEG_SPOP_SBC_1	0.1667
p.G351R	DO223723	LUSC	ICGC	PRSSS	DEG_SPOP_SBC_1	0.7568
p.L357F	DO47268	SKCM	ICGC	PRSSS	DEG_SPOP_SBC_1	0.3333
p.R341W	DO50301	SKCM	ICGC	PRSSS	DEG_SPOP_SBC_1	0.1111
p.L357I	DO42568	UCEC	ICGC	PRSSS	DEG_SPOP_SBC_1	0.3333
p.K340E	SIDM00949	T-Cell Non-Hodgkin's Lymphoma	GDSC	PRSSS	DEG_SPOP_SBC_1	0.1944
p.K340E	ACH-000233	Lymphoma	CCLE	PRSSS	DEG_SPOP_SBC_1	0.1944
p.K340E	DEL	haematopoietic_and_lymphoid_tissue	COSMIC	PRSSS	DEG_SPOP_SBC_1	0.1944
p.S342L	SK-UT-1	soft_tissue	COSMIC	PRSSS	DEG_SPOP_SBC_1	0.1389
p.L357P	KMS-11	haematopoietic_and_lymphoid_tissue	COSMIC	PRSSS	DEG_SPOP_SBC_1	0.3333
p.L357P	A3-KAW	haematopoietic_and_lymphoid_tissue	COSMIC	PRSSS	DEG_SPOP_SBC_1	0.3333
p.C340F	A427	lung	COSMIC	PRSSS	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A7KAX9	Rho GTPase-activating protein 32	DEG_SPOP_SBC_1	728:732	PRSSS	SPOP	0.9943	More...
O75069	Transmembrane and coiled-coil domains protein 2	DEG_SPOP_SBC_1	218:222	PRSSS	SPOP	0.6944	More...
O75081	Protein CBFA2T3	DEG_SPOP_SBC_1	455:459	PRSSS	SPOP	0.6229	More...
O75592	E3 ubiquitin-protein ligase MYCBP2	DEG_SPOP_SBC_1	2840:2844	PRSSS	SPOP	0.9962	More...
O94876	Transmembrane and coiled-coil domains protein 1	DEG_SPOP_SBC_1	154:158	PRSSS	SPOP	0.9256	More...
O94964	Protein SOGA1	DEG_SPOP_SBC_1	1168:1172	PRSSS	SPOP	0.9994	More...
P41182	B-cell lymphoma 6 protein	DEG_SPOP_SBC_1	458:462	PRSSS	SPOP	0.5537	More...
P49619	Diacylglycerol kinase gamma	DEG_SPOP_SBC_1	149:153	PRSSS	SPOP	0.5556	More...
P55201	Peregrin	DEG_SPOP_SBC_1	995:999	PRSSS	SPOP	0.9038	More...
P78386	Keratin, type II cuticular Hb5	DEG_SPOP_SBC_1	491:495	PRSSS	SPOP	0.8473	More...
P98177	Forkhead box protein O4	DEG_SPOP_SBC_1	258:262	PRSSS	SPOP	0.9997	More...
Q13478	Interleukin-18 receptor 1	DEG_SPOP_SBC_1	70:74	PRSSS	SPOP	0.7325	More...
Q13515	Phakinin	DEG_SPOP_SBC_1	30:34	PRSSS	SPOP	0.9701	More...
Q15431	Synaptonemal complex protein 1	DEG_SPOP_SBC_1	13:17	PRSSS	SPOP	0.9396	More...
Q5CZC0	Fibrous sheath-interacting protein 2	DEG_SPOP_SBC_1	4128:4132	PRSSS	SPOP	0.709	More...
Q5SQI0	Alpha-tubulin N-acetyltransferase 1	DEG_SPOP_SBC_1	268:272	PRSSS	SPOP	0.9882	More...
Q6GYQ0	Ral GTPase-activating protein subunit alpha-1	DEG_SPOP_SBC_1	793:797	PRSSS	SPOP	0.9994	More...
Q6IQ55	Tau-tubulin kinase 2	DEG_SPOP_SBC_1	1155:1159	PRSSS	SPOP	0.8733	More...
Q86TC9	Myopalladin	DEG_SPOP_SBC_1	588:592	PRSSS	SPOP	0.7566	More...
Q86UU0	B-cell CLL/lymphoma 9-like protein	DEG_SPOP_SBC_1	1049:1053	PRSSS	SPOP	0.9955	More...
Q8N2C7	Protein unc-80 homolog	DEG_SPOP_SBC_1	381:385	PRSSS	SPOP	0.9941	More...
Q8NE31	Protein FAM13C	DEG_SPOP_SBC_1	269:273	PRSSS	SPOP	0.9952	More...
Q8NEM0	Microcephalin	DEG_SPOP_SBC_1	349:353	PRSSS	SPOP	0.9918	More...
Q8TDI7	Transmembrane channel-like protein 2	DEG_SPOP_SBC_1	133:137	PRSSS	SPOP	0.9412	More...
Q8WXI9	Transcriptional repressor p66-beta	DEG_SPOP_SBC_1	136:140	PRSSS	SPOP	0.9922	More...
Q92794	Histone acetyltransferase KAT6A	DEG_SPOP_SBC_1	997:1001	PRSSS	SPOP	0.8724	More...
Q9H2D6	TRIO and F-actin-binding protein	DEG_SPOP_SBC_1	824:828	PRSSS	SPOP	0.9957	More...
Q9H992	E3 ubiquitin-protein ligase MARCHF7	DEG_SPOP_SBC_1	125:129	PRSSS	SPOP	0.8611	More...
Q9HCK8	Chromodomain-helicase-DNA-binding protein 8	DEG_SPOP_SBC_1	2216:2220	PRSSS	SPOP	0.9419	More...
Q9NYF8	Bcl-2-associated transcription factor 1	DEG_SPOP_SBC_1	139:143	PRSSS	SPOP	0.9945	More...
Q9P218	Collagen alpha-1	DEG_SPOP_SBC_1	1019:1023	PRSSS	SPOP	0.8033	More...
Q9UK33	Zinc finger protein 580	DEG_SPOP_SBC_1	11:15	PRSSS	SPOP	0.9779	More...
Q9UQB8	Brain-specific angiogenesis inhibitor 1-associated protein 2	DEG_SPOP_SBC_1	362:366	PRSSS	SPOP	0.9997	More...
Q9UQD0	Sodium channel protein type 8 subunit alpha	DEG_SPOP_SBC_1	474:478	PRSSS	SPOP	0.9727	More...
Q9Y2K6	Ubiquitin carboxyl-terminal hydrolase 20	DEG_SPOP_SBC_1	369:373	PRSSS	SPOP	0.9939	More...
Q5JSZ5	Protein PRRC2B	DEG_SPOP_SBC_1	922:926	PRSSS	SPOP	0.8891	More...
Q9Y4E6	WD repeat-containing protein 7	DEG_SPOP_SBC_1	1150:1154	PRSSS	SPOP	0.6871	More...
Q17RH7	Putative protein TPRXL	DEG_SPOP_SBC_1	203:207	PRSSS	SPOP	0.7838	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PRSSS

Degron related mutations and impact score

Drug responses associated with MCPH1 mutations

All proteins holding degron of PRSSS