DegronMD - P49619(DGKG)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S156F	TCGA-BF-A1PX	SKCM	TCGA	PRSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.25
p.S156F	TCGA-EB-A41A	SKCM	TCGA	PRSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.25
p.S156F	DO37429	SKCM	ICGC	PRSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.25
p.S156F	DO51236	SKCM	ICGC	PRSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.25
p.S156F	SIDM01257	Hepatocellular Carcinoma	GDSC	PRSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.25
p.S156F	SIDM00062	Hepatocellular Carcinoma	GDSC	PRSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.25
p.S156F	ACH-000671	Liver Cancer	CCLE	PRSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.25
p.S156F	ACH-002395	Liver Cancer	CCLE	PRSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.25
p.S156F	HUH-6-clone5	liver	COSMIC	PRSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.25
p.S151F	TCGA-BQ-7060	KIRP	TCGA	PRSSS	DEG_SPOP_SBC_1	149:153	Mutation altering degron motif	0.7982
p.S151F	TCGA-FW-A3R5	SKCM	TCGA	PRSSS	DEG_SPOP_SBC_1	149:153	Mutation altering degron motif	0.7982
p.S151F	DO20831	KIRP	ICGC	PRSSS	DEG_SPOP_SBC_1	149:153	Mutation altering degron motif	0.7982
p.S151F	DO37406	SKCM	ICGC	PRSSS	DEG_SPOP_SBC_1	149:153	Mutation altering degron motif	0.7982
p.S151P	TCGA-CN-A499	HNSC	TCGA	PRSSS	DEG_SPOP_SBC_1	149:153	Mutation altering degron motif	0.6752
p.S151P	DO52040	HNSC	ICGC	PRSSS	DEG_SPOP_SBC_1	149:153	Mutation altering degron motif	0.6752
p.P147L	TCGA-CU-A3KJ	BLCA	TCGA	PRSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.2778
p.P147L	DO663	BLCA	ICGC	PRSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.2778
p.E155D	TCGA-DA-A95X	SKCM	TCGA	PRSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.2778
p.E155D	DO219480	SKCM	ICGC	PRSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.2778
p.D163N	TCGA-EB-A44P	SKCM	TCGA	PRSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.0556
p.D163N	DO222731	MELA	ICGC	PRSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.0556
p.D163N	DO47525	SKCM	ICGC	PRSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.0556
p.S154L	TCGA-EO-A3AV	UCEC	TCGA	PRSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.3056
p.S154L	TCGA-EO-A3B0	UCEC	TCGA	PRSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.3056
p.S154L	DO8898	COAD	ICGC	PRSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.3056
p.S154L	DO50407	ESAD	ICGC	PRSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.3056
p.S154L	DO233884	GACA	ICGC	PRSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.3056
p.S154L	DO219773	UCEC	ICGC	PRSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.3056
p.S154L	DO52412	UCEC	ICGC	PRSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.3056
p.S154L	SIDM00687	Gastric Carcinoma	GDSC	PRSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.3056
p.S154L	ACH-000793	Gastric Cancer	CCLE	PRSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.3056
p.S154L	KATOIII	stomach	COSMIC	PRSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.3056
p.S151T	TCGA-O2-A52N	LUSC	TCGA	PRSSS	DEG_SPOP_SBC_1	149:153	Mutation altering degron motif	0.6005
p.S151T	DO219217	LUSC	ICGC	PRSSS	DEG_SPOP_SBC_1	149:153	Mutation altering degron motif	0.6005
p.T142S	DO229013	COCA	ICGC	PRSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.1389
p.T142S	DO229016	COCA	ICGC	PRSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.1389
p.T142S	DO229003	COCA	ICGC	PRSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.1389
p.T142S	DO230659	LAML	ICGC	PRSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.1389
p.T142S	DO225404	LAML	ICGC	PRSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.1389
p.T142S	DO231140	LAML	ICGC	PRSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.1389
p.T142S	DO228947	LICA	ICGC	PRSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.1389
p.V148I	DO233275	GACA	ICGC	PRSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.3056
p.V148I	SIDM00958	Chronic Myelogenous Leukemia	GDSC	PRSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.3056
p.V148I	ACH-000920	Leukemia	CCLE	PRSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.3056
p.V148I	CML-T1	haematopoietic and lymphoid tissue	COSMIC	PRSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.3056
p.A141S	DO228957	LICA	ICGC	PRSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.1111
p.L144M	DO229026	LICA	ICGC	PRSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.1944
p.SE154SK	DO222542	MELA	ICGC	PRSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0
p.A141V	DO35156	PACA	ICGC	PRSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.1111
p.P157Q	SIDM01129	Small Cell Lung Carcinoma	GDSC	PRSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.2222
p.P157Q	ACH-000816	Lung Cancer	CCLE	PRSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.2222
p.P157Q	NCI-H524	lung	COSMIC	PRSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.2222
p.P157T	SIDM01129	Small Cell Lung Carcinoma	GDSC	PRSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.2222
p.P157T	ACH-000816	Lung Cancer	CCLE	PRSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.2222
p.P157T	NCI-H524	lung	COSMIC	PRSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.2222

Kaplan plot for DGKG in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DGKG

UniProt ID: P49619

Entrez ID: 1608

Protein name: Diacylglycerol kinase gamma (DAG kinase gamma) (EC 2.7.1.107) (Diglyceride kinase gamma) (DGK-gamma)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DGKG in