DegronMD

Uniprot ID: P49619

Source protein: Diacylglycerol kinase gamma

Source gene: DGKG

Class: DEG_SPOP_SBC_1

Location: 149:153

E3 ligase: SPOP

DEGRON score: 0.5556

ASA_SCORE: 89.14

COIL: 0.9154

CONS_SCORE: 0.252

DSS_SCORE: 0.5051

HELIX: 0.0378

FCONS_SCORE: 0.9643

RIG_SCORE: 0.5835

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S156F	TCGA-BF-A1PX	SKCM	TCGA	PRSSS	DEG_SPOP_SBC_1	0.25
p.S156F	TCGA-EB-A41A	SKCM	TCGA	PRSSS	DEG_SPOP_SBC_1	0.25
p.S156F	DO37429	SKCM	ICGC	PRSSS	DEG_SPOP_SBC_1	0.25
p.S156F	DO51236	SKCM	ICGC	PRSSS	DEG_SPOP_SBC_1	0.25
p.S156F	SIDM01257	Hepatocellular Carcinoma	GDSC	PRSSS	DEG_SPOP_SBC_1	0.25
p.S156F	SIDM00062	Hepatocellular Carcinoma	GDSC	PRSSS	DEG_SPOP_SBC_1	0.25
p.S156F	ACH-000671	Liver Cancer	CCLE	PRSSS	DEG_SPOP_SBC_1	0.25
p.S156F	ACH-002395	Liver Cancer	CCLE	PRSSS	DEG_SPOP_SBC_1	0.25
p.S156F	HUH-6-clone5	liver	COSMIC	PRSSS	DEG_SPOP_SBC_1	0.25
p.S151F	TCGA-BQ-7060	KIRP	TCGA	PRSSS	DEG_SPOP_SBC_1	0.7982
p.S151F	TCGA-FW-A3R5	SKCM	TCGA	PRSSS	DEG_SPOP_SBC_1	0.7982
p.S151F	DO20831	KIRP	ICGC	PRSSS	DEG_SPOP_SBC_1	0.7982
p.S151F	DO37406	SKCM	ICGC	PRSSS	DEG_SPOP_SBC_1	0.7982
p.S151P	TCGA-CN-A499	HNSC	TCGA	PRSSS	DEG_SPOP_SBC_1	0.6752
p.S151P	DO52040	HNSC	ICGC	PRSSS	DEG_SPOP_SBC_1	0.6752
p.P147L	TCGA-CU-A3KJ	BLCA	TCGA	PRSSS	DEG_SPOP_SBC_1	0.2778
p.P147L	DO663	BLCA	ICGC	PRSSS	DEG_SPOP_SBC_1	0.2778
p.E155D	TCGA-DA-A95X	SKCM	TCGA	PRSSS	DEG_SPOP_SBC_1	0.2778
p.E155D	DO219480	SKCM	ICGC	PRSSS	DEG_SPOP_SBC_1	0.2778
p.D163N	TCGA-EB-A44P	SKCM	TCGA	PRSSS	DEG_SPOP_SBC_1	0.0556
p.D163N	DO222731	MELA	ICGC	PRSSS	DEG_SPOP_SBC_1	0.0556
p.D163N	DO47525	SKCM	ICGC	PRSSS	DEG_SPOP_SBC_1	0.0556
p.S154L	TCGA-EO-A3AV	UCEC	TCGA	PRSSS	DEG_SPOP_SBC_1	0.3056
p.S154L	TCGA-EO-A3B0	UCEC	TCGA	PRSSS	DEG_SPOP_SBC_1	0.3056
p.S154L	DO8898	COAD	ICGC	PRSSS	DEG_SPOP_SBC_1	0.3056
p.S154L	DO50407	ESAD	ICGC	PRSSS	DEG_SPOP_SBC_1	0.3056
p.S154L	DO233884	GACA	ICGC	PRSSS	DEG_SPOP_SBC_1	0.3056
p.S154L	DO219773	UCEC	ICGC	PRSSS	DEG_SPOP_SBC_1	0.3056
p.S154L	DO52412	UCEC	ICGC	PRSSS	DEG_SPOP_SBC_1	0.3056
p.S154L	SIDM00687	Gastric Carcinoma	GDSC	PRSSS	DEG_SPOP_SBC_1	0.3056
p.S154L	ACH-000793	Gastric Cancer	CCLE	PRSSS	DEG_SPOP_SBC_1	0.3056
p.S154L	KATOIII	stomach	COSMIC	PRSSS	DEG_SPOP_SBC_1	0.3056
p.S151T	TCGA-O2-A52N	LUSC	TCGA	PRSSS	DEG_SPOP_SBC_1	0.6005
p.S151T	DO219217	LUSC	ICGC	PRSSS	DEG_SPOP_SBC_1	0.6005
p.T142S	DO229013	COCA	ICGC	PRSSS	DEG_SPOP_SBC_1	0.1389
p.T142S	DO229016	COCA	ICGC	PRSSS	DEG_SPOP_SBC_1	0.1389
p.T142S	DO229003	COCA	ICGC	PRSSS	DEG_SPOP_SBC_1	0.1389
p.T142S	DO230659	LAML	ICGC	PRSSS	DEG_SPOP_SBC_1	0.1389
p.T142S	DO225404	LAML	ICGC	PRSSS	DEG_SPOP_SBC_1	0.1389
p.T142S	DO231140	LAML	ICGC	PRSSS	DEG_SPOP_SBC_1	0.1389
p.T142S	DO228947	LICA	ICGC	PRSSS	DEG_SPOP_SBC_1	0.1389
p.V148I	DO233275	GACA	ICGC	PRSSS	DEG_SPOP_SBC_1	0.3056
p.V148I	SIDM00958	Chronic Myelogenous Leukemia	GDSC	PRSSS	DEG_SPOP_SBC_1	0.3056
p.V148I	ACH-000920	Leukemia	CCLE	PRSSS	DEG_SPOP_SBC_1	0.3056
p.V148I	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	PRSSS	DEG_SPOP_SBC_1	0.3056
p.A141S	DO228957	LICA	ICGC	PRSSS	DEG_SPOP_SBC_1	0.1111
p.L144M	DO229026	LICA	ICGC	PRSSS	DEG_SPOP_SBC_1	0.1944
p.SE154SK	DO222542	MELA	ICGC	PRSSS	DEG_SPOP_SBC_1	0
p.A141V	DO35156	PACA	ICGC	PRSSS	DEG_SPOP_SBC_1	0.1111
p.P157Q	SIDM01129	Small Cell Lung Carcinoma	GDSC	PRSSS	DEG_SPOP_SBC_1	0.2222
p.P157Q	ACH-000816	Lung Cancer	CCLE	PRSSS	DEG_SPOP_SBC_1	0.2222
p.P157Q	NCI-H524	lung	COSMIC	PRSSS	DEG_SPOP_SBC_1	0.2222
p.P157T	SIDM01129	Small Cell Lung Carcinoma	GDSC	PRSSS	DEG_SPOP_SBC_1	0.2222
p.P157T	ACH-000816	Lung Cancer	CCLE	PRSSS	DEG_SPOP_SBC_1	0.2222
p.P157T	NCI-H524	lung	COSMIC	PRSSS	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A7KAX9	Rho GTPase-activating protein 32	DEG_SPOP_SBC_1	728:732	PRSSS	SPOP	0.9943	More...
O75069	Transmembrane and coiled-coil domains protein 2	DEG_SPOP_SBC_1	218:222	PRSSS	SPOP	0.6944	More...
O75081	Protein CBFA2T3	DEG_SPOP_SBC_1	455:459	PRSSS	SPOP	0.6229	More...
O75592	E3 ubiquitin-protein ligase MYCBP2	DEG_SPOP_SBC_1	2840:2844	PRSSS	SPOP	0.9962	More...
O94876	Transmembrane and coiled-coil domains protein 1	DEG_SPOP_SBC_1	154:158	PRSSS	SPOP	0.9256	More...
O94964	Protein SOGA1	DEG_SPOP_SBC_1	1168:1172	PRSSS	SPOP	0.9994	More...
P41182	B-cell lymphoma 6 protein	DEG_SPOP_SBC_1	458:462	PRSSS	SPOP	0.5537	More...
P49619	Diacylglycerol kinase gamma	DEG_SPOP_SBC_1	149:153	PRSSS	SPOP	0.5556	More...
P55201	Peregrin	DEG_SPOP_SBC_1	995:999	PRSSS	SPOP	0.9038	More...
P78386	Keratin, type II cuticular Hb5	DEG_SPOP_SBC_1	491:495	PRSSS	SPOP	0.8473	More...
P98177	Forkhead box protein O4	DEG_SPOP_SBC_1	258:262	PRSSS	SPOP	0.9997	More...
Q13478	Interleukin-18 receptor 1	DEG_SPOP_SBC_1	70:74	PRSSS	SPOP	0.7325	More...
Q13515	Phakinin	DEG_SPOP_SBC_1	30:34	PRSSS	SPOP	0.9701	More...
Q15431	Synaptonemal complex protein 1	DEG_SPOP_SBC_1	13:17	PRSSS	SPOP	0.9396	More...
Q5CZC0	Fibrous sheath-interacting protein 2	DEG_SPOP_SBC_1	4128:4132	PRSSS	SPOP	0.709	More...
Q5SQI0	Alpha-tubulin N-acetyltransferase 1	DEG_SPOP_SBC_1	268:272	PRSSS	SPOP	0.9882	More...
Q6GYQ0	Ral GTPase-activating protein subunit alpha-1	DEG_SPOP_SBC_1	793:797	PRSSS	SPOP	0.9994	More...
Q6IQ55	Tau-tubulin kinase 2	DEG_SPOP_SBC_1	1155:1159	PRSSS	SPOP	0.8733	More...
Q86TC9	Myopalladin	DEG_SPOP_SBC_1	588:592	PRSSS	SPOP	0.7566	More...
Q86UU0	B-cell CLL/lymphoma 9-like protein	DEG_SPOP_SBC_1	1049:1053	PRSSS	SPOP	0.9955	More...
Q8N2C7	Protein unc-80 homolog	DEG_SPOP_SBC_1	381:385	PRSSS	SPOP	0.9941	More...
Q8NE31	Protein FAM13C	DEG_SPOP_SBC_1	269:273	PRSSS	SPOP	0.9952	More...
Q8NEM0	Microcephalin	DEG_SPOP_SBC_1	349:353	PRSSS	SPOP	0.9918	More...
Q8TDI7	Transmembrane channel-like protein 2	DEG_SPOP_SBC_1	133:137	PRSSS	SPOP	0.9412	More...
Q8WXI9	Transcriptional repressor p66-beta	DEG_SPOP_SBC_1	136:140	PRSSS	SPOP	0.9922	More...
Q92794	Histone acetyltransferase KAT6A	DEG_SPOP_SBC_1	997:1001	PRSSS	SPOP	0.8724	More...
Q9H2D6	TRIO and F-actin-binding protein	DEG_SPOP_SBC_1	824:828	PRSSS	SPOP	0.9957	More...
Q9H992	E3 ubiquitin-protein ligase MARCHF7	DEG_SPOP_SBC_1	125:129	PRSSS	SPOP	0.8611	More...
Q9HCK8	Chromodomain-helicase-DNA-binding protein 8	DEG_SPOP_SBC_1	2216:2220	PRSSS	SPOP	0.9419	More...
Q9NYF8	Bcl-2-associated transcription factor 1	DEG_SPOP_SBC_1	139:143	PRSSS	SPOP	0.9945	More...
Q9P218	Collagen alpha-1	DEG_SPOP_SBC_1	1019:1023	PRSSS	SPOP	0.8033	More...
Q9UK33	Zinc finger protein 580	DEG_SPOP_SBC_1	11:15	PRSSS	SPOP	0.9779	More...
Q9UQB8	Brain-specific angiogenesis inhibitor 1-associated protein 2	DEG_SPOP_SBC_1	362:366	PRSSS	SPOP	0.9997	More...
Q9UQD0	Sodium channel protein type 8 subunit alpha	DEG_SPOP_SBC_1	474:478	PRSSS	SPOP	0.9727	More...
Q9Y2K6	Ubiquitin carboxyl-terminal hydrolase 20	DEG_SPOP_SBC_1	369:373	PRSSS	SPOP	0.9939	More...
Q5JSZ5	Protein PRRC2B	DEG_SPOP_SBC_1	922:926	PRSSS	SPOP	0.8891	More...
Q9Y4E6	WD repeat-containing protein 7	DEG_SPOP_SBC_1	1150:1154	PRSSS	SPOP	0.6871	More...
Q17RH7	Putative protein TPRXL	DEG_SPOP_SBC_1	203:207	PRSSS	SPOP	0.7838	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PRSSS

Degron related mutations and impact score

Drug responses associated with DGKG mutations

All proteins holding degron of PRSSS