DegronMD - P55201(BRPF1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G881C	TCGA-17-Z026	LUAD	TCGA	MSSTPAHE	DEG_SCF_FBW7_2	878:885	Mutation altering degron motif	0.76
p.R895K	TCGA-A5-A2K5	UCEC	TCGA	MSSTPAHE	DEG_SCF_FBW7_2	878:885	Mutation blocking phosphorylation signal	0.5
p.D445G	TCGA-A6-3809	COAD	TCGA	IHTPPGS	DEG_SCF_FBW7_1	446:452	Mutation rewiring degron network	0.3056
p.D445G	DO8722	COAD	ICGC	IHTPPGS	DEG_SCF_FBW7_1	446:452	Mutation rewiring degron network	0.3056
p.D445G	ACH-002287	Colon/Colorectal Cancer	CCLE	IHTPPGS	DEG_SCF_FBW7_1	446:452	Mutation rewiring degron network	0.3056
p.R950W	TCGA-AA-3811	COAD	TCGA	PSSSS	DEG_SPOP_SBC_1	950:954	Mutation altering degron motif	0.8634
p.R955G	TCGA-AX-A3FT	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	950:954	Mutation rewiring degron network	0.3056
p.D997Y	TCGA-B5-A1MR	UCEC	TCGA	PRSSS	DEG_SPOP_SBC_1	995:999	Mutation altering degron motif	0.7325
p.G879C	TCGA-BQ-7060	KIRP	TCGA	MSSTPAHE	DEG_SCF_FBW7_2	878:885	Mutation altering degron motif	0.76
p.P457S	TCGA-BR-8081	STAD	TCGA	IHTPPGS	DEG_SCF_FBW7_1	446:452	Mutation rewiring degron network	0.1944
p.P457S	DO38795	STAD	ICGC	IHTPPGS	DEG_SCF_FBW7_1	446:452	Mutation rewiring degron network	0.1944
p.R439H	TCGA-CV-A45W	HNSC	TCGA	IHTPPGS	DEG_SCF_FBW7_1	446:452	Mutation rewiring degron network	0.1389
p.R439H	DO52060	HNSC	ICGC	IHTPPGS	DEG_SCF_FBW7_1	446:452	Mutation rewiring degron network	0.1389
p.M942L	TCGA-CZ-5468	KIRC	TCGA	PSSSS	DEG_SPOP_SBC_1	950:954	Mutation rewiring degron network	0.1111
p.R439S	TCGA-D3-A2JN	SKCM	TCGA	IHTPPGS	DEG_SCF_FBW7_1	446:452	Mutation rewiring degron network	0.1389
p.R439S	DO47590	SKCM	ICGC	IHTPPGS	DEG_SCF_FBW7_1	446:452	Mutation rewiring degron network	0.1389
p.P882S	TCGA-EE-A3AE	SKCM	TCGA	MSSTPAHE	DEG_SCF_FBW7_2	878:885	Mutation altering degron motif	0.6752
p.P954L	TCGA-FS-A1Z3	SKCM	TCGA	PSSSS	DEG_SPOP_SBC_1	950:954	Mutation altering degron motif	0.7582
p.A889T	TCGA-NH-A5IV	COAD	TCGA	MSSTPAHE	DEG_SCF_FBW7_2	878:885	Mutation rewiring degron network	0.2222
p.E1008K	TCGA-NK-A5CT	LUSC	TCGA	PRSSS	DEG_SPOP_SBC_1	995:999	Mutation rewiring degron network	0.0833
p.S944F	TCGA-WE-A8K5	SKCM	TCGA	PSSSS	DEG_SPOP_SBC_1	950:954	Mutation rewiring degron network	0.1667
p.S944F	SIDM01175	Other Sarcomas	GDSC	PSSSS	DEG_SPOP_SBC_1	950:954	Mutation rewiring degron network	0.1667
p.S944F	SW684	soft tissue	COSMIC	PSSSS	DEG_SPOP_SBC_1	950:954	Mutation rewiring degron network	0.1667
p.F436L	TCGA-WX-AA46	LIHC	TCGA	IHTPPGS	DEG_SCF_FBW7_1	446:452	Mutation rewiring degron network	0.0556
p.F436L	DO219583	LIHC	ICGC	IHTPPGS	DEG_SCF_FBW7_1	446:452	Mutation rewiring degron network	0.0556
p.A882T	DO49095	COAD	ICGC	MSSTPAHE	DEG_SCF_FBW7_2	878:885	Mutation altering degron motif	0.7139
p.R943W	DO7962	COAD	ICGC	PSSSS	DEG_SPOP_SBC_1	950:954	Mutation substituting flanking lysine	0.25
p.S951L	DO8898	COAD	ICGC	PSSSS	DEG_SPOP_SBC_1	950:954	Mutation altering degron motif	0.6556
p.S1004G	DO227657	COCA	ICGC	PRSSS	DEG_SPOP_SBC_1	995:999	Mutation rewiring degron network	0.1944
p.Q941R	DO233276	GACA	ICGC	PSSSS	DEG_SPOP_SBC_1	950:954	Mutation rewiring degron network	0.0833
p.T448M	DO233942	GACA	ICGC	IHTPPGS	DEG_SCF_FBW7_1	446:452	Mutation altering degron motif	0.8534
p.F893L	DO13863	GBM	ICGC	MSSTPAHE	DEG_SCF_FBW7_2	878:885	Mutation rewiring degron network	0.1111
p.G872C	DO20831	KIRP	ICGC	MSSTPAHE	DEG_SCF_FBW7_2	878:885	Mutation substituting flanking lysine	0.2778
p.R940L	DO229024	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	950:954	Mutation rewiring degron network	0.0556
p.S1006I	DO229027	LICA	ICGC	PRSSS	DEG_SPOP_SBC_1	995:999	Mutation rewiring degron network	0.1389
p.S437I	DO229008	LICA	ICGC	IHTPPGS	DEG_SCF_FBW7_1	446:452	Mutation blocking phosphorylation signal	0.5278
p.S996I	DO229008	LICA	ICGC	PRSSS	DEG_SPOP_SBC_1	995:999	Mutation altering degron motif	0.7341
p.D956Y	DO44798	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	950:954	Mutation rewiring degron network	0.2778
p.S1002Y	DO45037	LINC	ICGC	PRSSS	DEG_SPOP_SBC_1	995:999	Mutation rewiring degron network	0.25
p.E1002K	DO219209	LUSC	ICGC	PRSSS	DEG_SPOP_SBC_1	995:999	Mutation rewiring degron network	0.25
p.D445V	DO228880	MALY	ICGC	IHTPPGS	DEG_SCF_FBW7_1	446:452	Mutation rewiring degron network	0.3056
p.P947L	DO37635	SKCM	ICGC	PSSSS	DEG_SPOP_SBC_1	950:954	Mutation rewiring degron network	0.25
p.P876S	DO37802	SKCM	ICGC	MSSTPAHE	DEG_SCF_FBW7_2	878:885	Mutation rewiring degron network	0.2778
p.S891L	DO51301	SKCM	ICGC	MSSTPAHE	DEG_SCF_FBW7_2	878:885	Mutation blocking phosphorylation signal	0.6111
p.R948G	DO40801	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	950:954	Mutation rewiring degron network	0.2778
p.D991Y	DO41758	UCEC	ICGC	PRSSS	DEG_SPOP_SBC_1	995:999	Mutation rewiring degron network	0.2222
p.L892M	DO42793	UCEC	ICGC	MSSTPAHE	DEG_SCF_FBW7_2	878:885	Mutation rewiring degron network	0.1389
p.R888K	DO41379	UCEC	ICGC	MSSTPAHE	DEG_SCF_FBW7_2	878:885	Mutation rewiring degron network	0.25
p.Y994C	SIDM00661	B-Cell Non-Hodgkin's Lymphoma	GDSC	PRSSS	DEG_SPOP_SBC_1	995:999	Mutation rewiring degron network	0.3056
p.Y994C	HT	haematopoietic and lymphoid tissue	COSMIC	PRSSS	DEG_SPOP_SBC_1	995:999	Mutation rewiring degron network	0.3056
p.D963N	SIDM00151	Ovarian Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	950:954	Mutation rewiring degron network	0.0833
p.D963N	IGROV-1	ovary	COSMIC	PSSSS	DEG_SPOP_SBC_1	950:954	Mutation rewiring degron network	0.0833
p.Y987C	ACH-000914	Lymphoma	CCLE	PRSSS	DEG_SPOP_SBC_1	995:999	Mutation rewiring degron network	0.1111
p.Y987C	HT	haematopoietic and lymphoid tissue	COSMIC	PRSSS	DEG_SPOP_SBC_1	995:999	Mutation rewiring degron network	0.1111
p.D956N	ACH-000966	Ovarian Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	950:954	Mutation rewiring degron network	0.2778
p.D956N	IGROV-1	ovary	COSMIC	PSSSS	DEG_SPOP_SBC_1	950:954	Mutation rewiring degron network	0.2778
p.S437G	ACH-001518	Endometrial/Uterine Cancer	CCLE	IHTPPGS	DEG_SCF_FBW7_1	446:452	Mutation blocking phosphorylation signal	0.5278
p.S957C	UACC-812	breast	COSMIC	PSSSS	DEG_SPOP_SBC_1	950:954	Mutation rewiring degron network	0.25
p.Y988C	HT	haematopoietic and lymphoid tissue	COSMIC	PRSSS	DEG_SPOP_SBC_1	995:999	Mutation rewiring degron network	0.1389
p.S943G	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	PSSSS	DEG_SPOP_SBC_1	950:954	Mutation substituting flanking lysine	0.25
p.S943G	Daudi	haematopoietic and lymphoid tissue	COSMIC	PSSSS	DEG_SPOP_SBC_1	950:954	Mutation substituting flanking lysine	0.25
p.Y893C	HT	haematopoietic and lymphoid tissue	COSMIC	MSSTPAHE	DEG_SCF_FBW7_2	878:885	Mutation rewiring degron network	0.1111
p.S871R	SU-DHL-16	haematopoietic and lymphoid tissue	COSMIC	MSSTPAHE	DEG_SCF_FBW7_2	878:885	Mutation rewiring degron network	0.1389
p.G950S	CGTH-W-1	thyroid	COSMIC	PSSSS	DEG_SPOP_SBC_1	950:954	Mutation altering degron motif	0.6993
p.A876V	MKN45	stomach	COSMIC	MSSTPAHE	DEG_SCF_FBW7_2	878:885	Mutation rewiring degron network	0.2778
p.D957N	IGROV-1	ovary	COSMIC	PSSSS	DEG_SPOP_SBC_1	950:954	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BRPF1

UniProt ID: P55201

Entrez ID: 7862

Protein name: Peregrin (Bromodomain and PHD finger-containing protein 1) (Protein Br140)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for BRPF1 in