DegronMD

Uniprot ID: P55201

Source protein: Peregrin

Source gene: BRPF1

Class: DEG_SCF_FBW7_1

Location: 446:452

E3 ligase: FBXW7

DEGRON score: 0.9987

ASA_SCORE: 55.7286

COIL: 0.8733

CONS_SCORE: 0.5509

DSS_SCORE: 0.5189

HELIX: 0.0616

FCONS_SCORE: 1.4026

RIG_SCORE: 0.6671

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D445G	TCGA-A6-3809	COAD	TCGA	IHTPPGS	DEG_SCF_FBW7_1	0.3056
p.D445G	DO8722	COAD	ICGC	IHTPPGS	DEG_SCF_FBW7_1	0.3056
p.D445G	ACH-002287	Colon/Colorectal Cancer	CCLE	IHTPPGS	DEG_SCF_FBW7_1	0.3056
p.P457S	TCGA-BR-8081	STAD	TCGA	IHTPPGS	DEG_SCF_FBW7_1	0.1944
p.P457S	DO38795	STAD	ICGC	IHTPPGS	DEG_SCF_FBW7_1	0.1944
p.R439H	TCGA-CV-A45W	HNSC	TCGA	IHTPPGS	DEG_SCF_FBW7_1	0.1389
p.R439H	DO52060	HNSC	ICGC	IHTPPGS	DEG_SCF_FBW7_1	0.1389
p.R439S	TCGA-D3-A2JN	SKCM	TCGA	IHTPPGS	DEG_SCF_FBW7_1	0.1389
p.R439S	DO47590	SKCM	ICGC	IHTPPGS	DEG_SCF_FBW7_1	0.1389
p.F436L	TCGA-WX-AA46	LIHC	TCGA	IHTPPGS	DEG_SCF_FBW7_1	0.0556
p.F436L	DO219583	LIHC	ICGC	IHTPPGS	DEG_SCF_FBW7_1	0.0556
p.T448M	DO233942	GACA	ICGC	IHTPPGS	DEG_SCF_FBW7_1	0.8534
p.S437I	DO229008	LICA	ICGC	IHTPPGS	DEG_SCF_FBW7_1	0.5278
p.D445V	DO228880	MALY	ICGC	IHTPPGS	DEG_SCF_FBW7_1	0.3056
p.S437G	ACH-001518	Endometrial/Uterine Cancer	CCLE	IHTPPGS	DEG_SCF_FBW7_1	0.5278

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P55201	Peregrin	DEG_SCF_FBW7_1	446:452	IHTPPGS	FBXW7	0.9987	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons