DegronMD

Uniprot ID: P55201

Source protein: Peregrin

Source gene: BRPF1

Class: DEG_SCF_FBW7_2

Location: 878:885

E3 ligase: FBXW7

DEGRON score: 0.9202

ASA_SCORE: 82.525

COIL: 0.7758

CONS_SCORE: 0.3461

DSS_SCORE: 0.7334

HELIX: 0.1654

FCONS_SCORE: 1.0245

RIG_SCORE: 0.5918

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G881C	TCGA-17-Z026	LUAD	TCGA	MSSTPAHE	DEG_SCF_FBW7_2	0.76
p.R895K	TCGA-A5-A2K5	UCEC	TCGA	MSSTPAHE	DEG_SCF_FBW7_2	0.5
p.G879C	TCGA-BQ-7060	KIRP	TCGA	MSSTPAHE	DEG_SCF_FBW7_2	0.76
p.P882S	TCGA-EE-A3AE	SKCM	TCGA	MSSTPAHE	DEG_SCF_FBW7_2	0.6752
p.A889T	TCGA-NH-A5IV	COAD	TCGA	MSSTPAHE	DEG_SCF_FBW7_2	0.2222
p.A882T	DO49095	COAD	ICGC	MSSTPAHE	DEG_SCF_FBW7_2	0.7139
p.F893L	DO13863	GBM	ICGC	MSSTPAHE	DEG_SCF_FBW7_2	0.1111
p.G872C	DO20831	KIRP	ICGC	MSSTPAHE	DEG_SCF_FBW7_2	0.2778
p.P876S	DO37802	SKCM	ICGC	MSSTPAHE	DEG_SCF_FBW7_2	0.2778
p.S891L	DO51301	SKCM	ICGC	MSSTPAHE	DEG_SCF_FBW7_2	0.6111
p.L892M	DO42793	UCEC	ICGC	MSSTPAHE	DEG_SCF_FBW7_2	0.1389
p.R888K	DO41379	UCEC	ICGC	MSSTPAHE	DEG_SCF_FBW7_2	0.25
p.Y893C	HT	haematopoietic_and_lymphoid_tissue	COSMIC	MSSTPAHE	DEG_SCF_FBW7_2	0.1111
p.S871R	SU-DHL-16	haematopoietic_and_lymphoid_tissue	COSMIC	MSSTPAHE	DEG_SCF_FBW7_2	0.1389
p.A876V	MKN45	stomach	COSMIC	MSSTPAHE	DEG_SCF_FBW7_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P55201	Peregrin	DEG_SCF_FBW7_2	878:885	MSSTPAHE	FBXW7	0.9202	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons