DegronMD - Q6GYQ0(RALGAPA1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E375K	TCGA-21-1079	LUSC	TCGA	PSSSS	DEG_SPOP_SBC_1	378:382	Mutation rewiring degron network	0.25
p.E375K	DO26846	LUSC	ICGC	PSSSS	DEG_SPOP_SBC_1	378:382	Mutation rewiring degron network	0.25
p.S368C	TCGA-38-4628	LUAD	TCGA	PSSSS	DEG_SPOP_SBC_1	378:382	Mutation blocking phosphorylation signal	0.5
p.S368C	DO26354	LUAD	ICGC	PSSSS	DEG_SPOP_SBC_1	378:382	Mutation blocking phosphorylation signal	0.5
p.R794Q	TCGA-A5-A2K5	UCEC	TCGA	PRSSS	DEG_SPOP_SBC_1	793:797	Mutation altering degron motif	0.6218
p.R794Q	TCGA-AN-A046	BRCA	TCGA	PRSSS	DEG_SPOP_SBC_1	793:797	Mutation altering degron motif	0.6218
p.R794Q	DO1285	BRCA	ICGC	PRSSS	DEG_SPOP_SBC_1	793:797	Mutation altering degron motif	0.6218
p.R794Q	DO41379	UCEC	ICGC	PRSSS	DEG_SPOP_SBC_1	793:797	Mutation altering degron motif	0.6218
p.R794Q	ACH-001719	Ovarian Cancer	CCLE	PRSSS	DEG_SPOP_SBC_1	793:797	Mutation altering degron motif	0.6218
p.L462F	TCGA-AA-3986	COAD	TCGA	VITSS	DEG_SPOP_SBC_1	456:460	Mutation rewiring degron network	0.2778
p.L462F	DO8216	COAD	ICGC	VITSS	DEG_SPOP_SBC_1	456:460	Mutation rewiring degron network	0.2778
p.R1781M	TCGA-AA-A022	COAD	TCGA	CRLLLSILG	DEG_APCC_DBOX_1	1765:1773	Mutation rewiring degron network	0.1111
p.R1781M	DO10647	COAD	ICGC	CRLLLSILG	DEG_APCC_DBOX_1	1765:1773	Mutation rewiring degron network	0.1111
p.R846Q	TCGA-AJ-A5DW	UCEC	TCGA	SSANVPDL	DEG_COP1_1	831:838	Mutation rewiring degron network	0.1111
p.R846Q	DO50075	UCEC	ICGC	SSANVPDL	DEG_COP1_1	831:838	Mutation rewiring degron network	0.1111
p.E377K	TCGA-AP-A1DV	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	378:382	Mutation rewiring degron network	0.3056
p.E377K	DO43186	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	378:382	Mutation rewiring degron network	0.3056
p.D800Y	TCGA-AR-A5QQ	BRCA	TCGA	PRSSS	DEG_SPOP_SBC_1	793:797	Mutation rewiring degron network	0.25
p.D800Y	DO44135	BRCA	ICGC	PRSSS	DEG_SPOP_SBC_1	793:797	Mutation rewiring degron network	0.25
p.P463T	TCGA-BQ-7060	KIRP	TCGA	VITSS	DEG_SPOP_SBC_1	456:460	Mutation rewiring degron network	0.25
p.P463T	DO20831	KIRP	ICGC	VITSS	DEG_SPOP_SBC_1	456:460	Mutation rewiring degron network	0.25
p.E841K	TCGA-D8-A1JA	BRCA	TCGA	SSANVPDL	DEG_COP1_1	831:838	Mutation rewiring degron network	0.25
p.E841K	DO2819	BRCA	ICGC	SSANVPDL	DEG_COP1_1	831:838	Mutation rewiring degron network	0.25
p.P823A	TCGA-D9-A4Z6	SKCM	TCGA	SSANVPDL	DEG_COP1_1	831:838	Mutation rewiring degron network	0.1111
p.P823A	DO47485	SKCM	ICGC	SSANVPDL	DEG_COP1_1	831:838	Mutation rewiring degron network	0.1111
p.L847V	TCGA-DD-AACV	LIHC	TCGA	SSANVPDL	DEG_COP1_1	831:838	Mutation rewiring degron network	0.0833
p.L847V	DO219565	LIHC	ICGC	SSANVPDL	DEG_COP1_1	831:838	Mutation rewiring degron network	0.0833
p.G830S	TCGA-E2-A10A	BRCA	TCGA	SSANVPDL	DEG_COP1_1	831:838	Mutation rewiring degron network	0.3056
p.G830S	DO1376	BRCA	ICGC	SSANVPDL	DEG_COP1_1	831:838	Mutation rewiring degron network	0.3056
p.G830S	DO229030	LICA	ICGC	SSANVPDL	DEG_COP1_1	831:838	Mutation rewiring degron network	0.3056
p.Q1756P	TCGA-EE-A29P	SKCM	TCGA	CRLLLSILG	DEG_APCC_DBOX_1	1765:1773	Mutation rewiring degron network	0.0833
p.Q1756P	DO37916	SKCM	ICGC	CRLLLSILG	DEG_APCC_DBOX_1	1765:1773	Mutation rewiring degron network	0.0833
p.R848Q	TCGA-EY-A1G8	UCEC	TCGA	SSANVPDL	DEG_COP1_1	831:838	Mutation rewiring degron network	0.0556
p.R848Q	DO43578	UCEC	ICGC	SSANVPDL	DEG_COP1_1	831:838	Mutation rewiring degron network	0.0556
p.L1768F	TCGA-F5-6814	READ	TCGA	CRLLLSILG	DEG_APCC_DBOX_1	1765:1773	Mutation altering degron motif	0.587
p.L1768F	DO36556	READ	ICGC	CRLLLSILG	DEG_APCC_DBOX_1	1765:1773	Mutation altering degron motif	0.587
p.C464S	TCGA-Q1-A73O	CESC	TCGA	VITSS	DEG_SPOP_SBC_1	456:460	Mutation rewiring degron network	0.2222
p.C464S	DO51612	CESC	ICGC	VITSS	DEG_SPOP_SBC_1	456:460	Mutation rewiring degron network	0.2222
p.P463L	TCGA-WE-A8ZX	SKCM	TCGA	VITSS	DEG_SPOP_SBC_1	456:460	Mutation rewiring degron network	0.25
p.P463L	DO51291	SKCM	ICGC	VITSS	DEG_SPOP_SBC_1	456:460	Mutation rewiring degron network	0.25
p.P463S	TCGA-WE-A8ZX	SKCM	TCGA	VITSS	DEG_SPOP_SBC_1	456:460	Mutation rewiring degron network	0.25
p.P463S	DO219871	SKCA	ICGC	VITSS	DEG_SPOP_SBC_1	456:460	Mutation rewiring degron network	0.25
p.P463S	DO51291	SKCM	ICGC	VITSS	DEG_SPOP_SBC_1	456:460	Mutation rewiring degron network	0.25
p.D799N	DO51646	CESC	ICGC	PRSSS	DEG_SPOP_SBC_1	793:797	Mutation blocking phosphorylation signal	0.7222
p.P1758L	DO229010	COCA	ICGC	CRLLLSILG	DEG_APCC_DBOX_1	1765:1773	Mutation rewiring degron network	0.1389
p.P1758L	DO229480	LAML	ICGC	CRLLLSILG	DEG_APCC_DBOX_1	1765:1773	Mutation rewiring degron network	0.1389
p.D387Y	DO228944	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	378:382	Mutation rewiring degron network	0.1944
p.P836H	DO229015	LICA	ICGC	SSANVPDL	DEG_COP1_1	831:838	Mutation altering degron motif	0.7694
p.D800E	DO229015	LICA	ICGC	PRSSS	DEG_SPOP_SBC_1	793:797	Mutation rewiring degron network	0.25
p.L838M	DO229041	LICA	ICGC	SSANVPDL	DEG_COP1_1	831:838	Mutation altering degron motif	0.5999
p.T784A	DO26806	LUSC	ICGC	PRSSS	DEG_SPOP_SBC_1	793:797	Mutation rewiring degron network	0.0833
p.S825Y	DO26475	LUSC	ICGC	SSANVPDL	DEG_COP1_1	831:838	Mutation rewiring degron network	0.1667
p.P796L	DO222875	MELA	ICGC	PRSSS	DEG_SPOP_SBC_1	793:797	Mutation altering degron motif	0.7582
p.N369D	DO229232	THCA	ICGC	PSSSS	DEG_SPOP_SBC_1	378:382	Mutation rewiring degron network	0.0833
p.I844L	SIDM00845	Burkitt's Lymphoma	GDSC	SSANVPDL	DEG_COP1_1	831:838	Mutation rewiring degron network	0.1667
p.I844L	Daudi	haematopoietic and lymphoid tissue	COSMIC	SSANVPDL	DEG_COP1_1	831:838	Mutation rewiring degron network	0.1667
p.N787H	SIDM00845	Burkitt's Lymphoma	GDSC	PRSSS	DEG_SPOP_SBC_1	793:797	Mutation rewiring degron network	0.1667
p.N787H	Daudi	haematopoietic and lymphoid tissue	COSMIC	PRSSS	DEG_SPOP_SBC_1	793:797	Mutation rewiring degron network	0.1667
p.P446L	SIDM00007	Other Solid Cancers	GDSC	VITSS	DEG_SPOP_SBC_1	456:460	Mutation rewiring degron network	0.0556
p.P446L	ACH-001550	Skin Cancer	CCLE	VITSS	DEG_SPOP_SBC_1	456:460	Mutation rewiring degron network	0.0556
p.P446L	MCC13	skin	COSMIC	VITSS	DEG_SPOP_SBC_1	456:460	Mutation rewiring degron network	0.0556
p.P446S	SIDM00007	Other Solid Cancers	GDSC	VITSS	DEG_SPOP_SBC_1	456:460	Mutation rewiring degron network	0.0556
p.P446S	ACH-001550	Skin Cancer	CCLE	VITSS	DEG_SPOP_SBC_1	456:460	Mutation rewiring degron network	0.0556
p.P446S	MCC13	skin	COSMIC	VITSS	DEG_SPOP_SBC_1	456:460	Mutation rewiring degron network	0.0556
p.P790T	SIDM00783	Colorectal Carcinoma	GDSC	PRSSS	DEG_SPOP_SBC_1	793:797	Mutation rewiring degron network	0.25
p.P790T	HCT-116	large intestine	COSMIC	PRSSS	DEG_SPOP_SBC_1	793:797	Mutation rewiring degron network	0.25
p.E803K	SIDM00760	Small Cell Lung Carcinoma	GDSC	PRSSS	DEG_SPOP_SBC_1	793:797	Mutation rewiring degron network	0.1667
p.S839P	SIDM01608	Endometrial Carcinoma	GDSC	SSANVPDL	DEG_COP1_1	831:838	Mutation rewiring degron network	0.3056
p.S1768F	SIDM01682	Gastric Carcinoma	GDSC	CRLLLSILG	DEG_APCC_DBOX_1	1765:1773	Mutation altering degron motif	0.7982
p.P791S	SIDM01588	Endometrial Carcinoma	GDSC	PRSSS	DEG_SPOP_SBC_1	793:797	Mutation rewiring degron network	0.2778
p.P791S	ACH-000993	Endometrial/Uterine Cancer	CCLE	PRSSS	DEG_SPOP_SBC_1	793:797	Mutation rewiring degron network	0.2778
p.S381C	ACH-000923	Lymphoma	CCLE	PSSSS	DEG_SPOP_SBC_1	378:382	Mutation altering degron motif	0.8652
p.E824D	Daudi	haematopoietic and lymphoid tissue	COSMIC	SSANVPDL	DEG_COP1_1	831:838	Mutation rewiring degron network	0.1389
p.E824D	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	SSANVPDL	DEG_COP1_1	831:838	Mutation rewiring degron network	0.1389
p.N834H	Daudi	haematopoietic and lymphoid tissue	COSMIC	SSANVPDL	DEG_COP1_1	831:838	Mutation altering degron motif	0.6312

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RALGAPA1

UniProt ID: Q6GYQ0

Entrez ID: 253959

Protein name: Ral GTPase-activating protein subunit alpha-1 (GAP-related-interacting partner to E12) (GRIPE) (GTPase-activating Rap/Ran-GAP domain-like 1) (Tuberin-like protein 1) (p240)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RALGAPA1 in