DegronMD

Uniprot ID: Q6GYQ0

Source protein: Ral GTPase-activating protein subunit alpha-1

Source gene: RALGAPA1

Class: DEG_SPOP_SBC_1

Location: 456:460

E3 ligase: SPOP

DEGRON score: 0.9959

ASA_SCORE: 74.38

COIL: 0.8142

CONS_SCORE: 0.2758

DSS_SCORE: 0.4518

HELIX: 0.0786

FCONS_SCORE: 0.8113

RIG_SCORE: 0.7943

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L462F	TCGA-AA-3986	COAD	TCGA	VITSS	DEG_SPOP_SBC_1	0.2778
p.L462F	DO8216	COAD	ICGC	VITSS	DEG_SPOP_SBC_1	0.2778
p.P463T	TCGA-BQ-7060	KIRP	TCGA	VITSS	DEG_SPOP_SBC_1	0.25
p.P463T	DO20831	KIRP	ICGC	VITSS	DEG_SPOP_SBC_1	0.25
p.C464S	TCGA-Q1-A73O	CESC	TCGA	VITSS	DEG_SPOP_SBC_1	0.2222
p.C464S	DO51612	CESC	ICGC	VITSS	DEG_SPOP_SBC_1	0.2222
p.P463L	TCGA-WE-A8ZX	SKCM	TCGA	VITSS	DEG_SPOP_SBC_1	0.25
p.P463L	DO51291	SKCM	ICGC	VITSS	DEG_SPOP_SBC_1	0.25
p.P463S	TCGA-WE-A8ZX	SKCM	TCGA	VITSS	DEG_SPOP_SBC_1	0.25
p.P463S	DO219871	SKCA	ICGC	VITSS	DEG_SPOP_SBC_1	0.25
p.P463S	DO51291	SKCM	ICGC	VITSS	DEG_SPOP_SBC_1	0.25
p.P446L	SIDM00007	Other Solid Cancers	GDSC	VITSS	DEG_SPOP_SBC_1	0.0556
p.P446L	ACH-001550	Skin Cancer	CCLE	VITSS	DEG_SPOP_SBC_1	0.0556
p.P446L	MCC13	skin	COSMIC	VITSS	DEG_SPOP_SBC_1	0.0556
p.P446S	SIDM00007	Other Solid Cancers	GDSC	VITSS	DEG_SPOP_SBC_1	0.0556
p.P446S	ACH-001550	Skin Cancer	CCLE	VITSS	DEG_SPOP_SBC_1	0.0556
p.P446S	MCC13	skin	COSMIC	VITSS	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00764	Pyridoxal kinase	DEG_SPOP_SBC_1	184:188	VITSS	SPOP	0.6795	More...
O75928	E3 SUMO-protein ligase PIAS2	DEG_SPOP_SBC_1	606:610	VITSS	SPOP	0.5785	More...
O95677	Eyes absent homolog 4	DEG_SPOP_SBC_1	124:128	VITSS	SPOP	0.9997	More...
P28324	ETS domain-containing protein Elk-4	DEG_SPOP_SBC_1	332:336	VITSS	SPOP	0.9963	More...
Q6GYQ0	Ral GTPase-activating protein subunit alpha-1	DEG_SPOP_SBC_1	456:460	VITSS	SPOP	0.9959	More...
Q6WRI0	Immunoglobulin superfamily member 10	DEG_SPOP_SBC_1	1176:1180	VITSS	SPOP	0.918	More...
Q8IZD4	mRNA-decapping enzyme 1B	DEG_SPOP_SBC_1	571:575	VITSS	SPOP	0.9737	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	5819:5823	VITSS	SPOP	0.9816	More...
Q9Y467	Sal-like protein 2	DEG_SPOP_SBC_1	444:448	VITSS	SPOP	0.9233	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons