DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SPOP_SBC_1

Location: 5819:5823

E3 ligase: SPOP

DEGRON score: 0.9816

ASA_SCORE: 86.74

COIL: 0.7846

CONS_SCORE: 0

DSS_SCORE: 0.5616

HELIX: 0.017

FCONS_SCORE: 0

RIG_SCORE: 0.7807

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E5813D	TCGA-BA-6869	HNSC	TCGA	VITSS	DEG_SPOP_SBC_1	0.1667
p.E5813D	DO14250	HNSC	ICGC	VITSS	DEG_SPOP_SBC_1	0.1667
p.S5822F	TCGA-EE-A2MR	SKCM	TCGA	VITSS	DEG_SPOP_SBC_1	0.7982
p.S5822F	DO37819	SKCM	ICGC	VITSS	DEG_SPOP_SBC_1	0.7982
p.S5815F	TCGA-YG-AA3O	SKCM	TCGA	VITSS	DEG_SPOP_SBC_1	0.2222
p.S5815F	DO51299	SKCM	ICGC	VITSS	DEG_SPOP_SBC_1	0.2222
p.E5818A	DO50357	ESAD	ICGC	VITSS	DEG_SPOP_SBC_1	0.3056
p.T5826S	DO234363	ESAD	ICGC	VITSS	DEG_SPOP_SBC_1	0.25
p.T5825K	DO229031	LICA	ICGC	VITSS	DEG_SPOP_SBC_1	0.2778
p.T5825K	DO229034	LICA	ICGC	VITSS	DEG_SPOP_SBC_1	0.2778
p.S5823R	DO229041	LICA	ICGC	VITSS	DEG_SPOP_SBC_1	0.7427
p.D5831V	DO230976	LUSC	ICGC	VITSS	DEG_SPOP_SBC_1	0.1111
p.D5831V	DO224626	LUSC	ICGC	VITSS	DEG_SPOP_SBC_1	0.1111
p.G5829E	SIDM01483	Melanoma	GDSC	VITSS	DEG_SPOP_SBC_1	0.1667
p.G5829E	ACH-000582	Skin Cancer	CCLE	VITSS	DEG_SPOP_SBC_1	0.1667
p.G5829E	COLO-741	large_intestine	COSMIC	VITSS	DEG_SPOP_SBC_1	0.1667
p.P5830S	SIDM00656	Burkitt's Lymphoma	GDSC	VITSS	DEG_SPOP_SBC_1	0.1389
p.P5830S	SIDM00538	Esophageal Carcinoma	GDSC	VITSS	DEG_SPOP_SBC_1	0.1389
p.P5830S	SIDM00641	Burkitt's Lymphoma	GDSC	VITSS	DEG_SPOP_SBC_1	0.1389
p.P5830S	SIDM01525	Acute Myeloid Leukemia	GDSC	VITSS	DEG_SPOP_SBC_1	0.1389
p.T5825S	SIDM01622	Breast Carcinoma	GDSC	VITSS	DEG_SPOP_SBC_1	0.2778
p.T5825S	ACH-000721	Breast Cancer	CCLE	VITSS	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00764	Pyridoxal kinase	DEG_SPOP_SBC_1	184:188	VITSS	SPOP	0.6795	More...
O75928	E3 SUMO-protein ligase PIAS2	DEG_SPOP_SBC_1	606:610	VITSS	SPOP	0.5785	More...
O95677	Eyes absent homolog 4	DEG_SPOP_SBC_1	124:128	VITSS	SPOP	0.9997	More...
P28324	ETS domain-containing protein Elk-4	DEG_SPOP_SBC_1	332:336	VITSS	SPOP	0.9963	More...
Q6GYQ0	Ral GTPase-activating protein subunit alpha-1	DEG_SPOP_SBC_1	456:460	VITSS	SPOP	0.9959	More...
Q6WRI0	Immunoglobulin superfamily member 10	DEG_SPOP_SBC_1	1176:1180	VITSS	SPOP	0.918	More...
Q8IZD4	mRNA-decapping enzyme 1B	DEG_SPOP_SBC_1	571:575	VITSS	SPOP	0.9737	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	5819:5823	VITSS	SPOP	0.9816	More...
Q9Y467	Sal-like protein 2	DEG_SPOP_SBC_1	444:448	VITSS	SPOP	0.9233	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons