DegronMD - O95677(EYA4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P241S	TCGA-50-5051	LUAD	TCGA	APSST	DEG_SPOP_SBC_1	246:250	Mutation rewiring degron network	0.1944
p.P241S	DO24576	LUAD	ICGC	APSST	DEG_SPOP_SBC_1	246:250	Mutation rewiring degron network	0.1944
p.A116V	TCGA-A5-A2K3	UCEC	TCGA	VITSS	DEG_SPOP_SBC_1	124:128	Mutation rewiring degron network	0.1111
p.A116V	DO43899	UCEC	ICGC	VITSS	DEG_SPOP_SBC_1	124:128	Mutation rewiring degron network	0.1111
p.S296L	TCGA-AA-A00N	COAD	TCGA	PSSTS	DEG_SPOP_SBC_1	304:308	Mutation rewiring degron network	0.1111
p.S296L	TCGA-BS-A0UV	UCEC	TCGA	PSSTS	DEG_SPOP_SBC_1	304:308	Mutation rewiring degron network	0.1111
p.S296L	DO9876	COAD	ICGC	PSSTS	DEG_SPOP_SBC_1	304:308	Mutation rewiring degron network	0.1111
p.S296L	DO42793	UCEC	ICGC	PSSTS	DEG_SPOP_SBC_1	304:308	Mutation rewiring degron network	0.1111
p.P317S	TCGA-AP-A0LM	UCEC	TCGA	PSSTS	DEG_SPOP_SBC_1	304:308	Mutation rewiring degron network	0.0833
p.P317S	DO43306	UCEC	ICGC	PSSTS	DEG_SPOP_SBC_1	304:308	Mutation rewiring degron network	0.0833
p.L117P	TCGA-CK-5916	COAD	TCGA	VITSS	DEG_SPOP_SBC_1	124:128	Mutation rewiring degron network	0.1389
p.L117P	DO8786	COAD	ICGC	VITSS	DEG_SPOP_SBC_1	124:128	Mutation rewiring degron network	0.1389
p.T303K	TCGA-EE-A2GL	SKCM	TCGA	PSSTS	DEG_SPOP_SBC_1	304:308	Mutation rewiring degron network	0.3056
p.T303K	DO37434	SKCM	ICGC	PSSTS	DEG_SPOP_SBC_1	304:308	Mutation rewiring degron network	0.3056
p.G318R	TCGA-EE-A2MI	SKCM	TCGA	PSSTS	DEG_SPOP_SBC_1	304:308	Mutation rewiring degron network	0.0556
p.G318R	DO37531	SKCM	ICGC	PSSTS	DEG_SPOP_SBC_1	304:308	Mutation rewiring degron network	0.0556
p.G318E	TCGA-EE-A2MJ	SKCM	TCGA	PSSTS	DEG_SPOP_SBC_1	304:308	Mutation rewiring degron network	0.0556
p.G318E	DO38099	SKCM	ICGC	PSSTS	DEG_SPOP_SBC_1	304:308	Mutation rewiring degron network	0.0556
p.I251M	TCGA-EO-A3AV	UCEC	TCGA	APSST	DEG_SPOP_SBC_1	246:250	Mutation rewiring degron network	0.3056
p.I251M	DO52412	UCEC	ICGC	APSST	DEG_SPOP_SBC_1	246:250	Mutation rewiring degron network	0.3056
p.Q313H	TCGA-ER-A19P	SKCM	TCGA	PSSTS	DEG_SPOP_SBC_1	304:308	Mutation rewiring degron network	0.1944
p.Q313H	DO47623	SKCM	ICGC	PSSTS	DEG_SPOP_SBC_1	304:308	Mutation rewiring degron network	0.1944
p.M240I	TCGA-G4-6321	COAD	TCGA	APSST	DEG_SPOP_SBC_1	246:250	Mutation rewiring degron network	0.1667
p.M240I	DO9210	COAD	ICGC	APSST	DEG_SPOP_SBC_1	246:250	Mutation rewiring degron network	0.1667
p.G122R	TCGA-GN-A8LK	SKCM	TCGA	VITSS	DEG_SPOP_SBC_1	124:128	Mutation rewiring degron network	0.2778
p.G122R	DO51259	SKCM	ICGC	VITSS	DEG_SPOP_SBC_1	124:128	Mutation rewiring degron network	0.2778
p.D114N	TCGA-HU-A4HD	STAD	TCGA	VITSS	DEG_SPOP_SBC_1	124:128	Mutation rewiring degron network	0.0556
p.D114N	DO47989	STAD	ICGC	VITSS	DEG_SPOP_SBC_1	124:128	Mutation rewiring degron network	0.0556
p.T307N	TCGA-KM-8439	KICH	TCGA	PSSTS	DEG_SPOP_SBC_1	304:308	Mutation altering degron motif	0.7055
p.T307N	DO220356	KICH	ICGC	PSSTS	DEG_SPOP_SBC_1	304:308	Mutation altering degron motif	0.7055
p.Y138H	DO225232	BRCA	ICGC	VITSS	DEG_SPOP_SBC_1	124:128	Mutation rewiring degron network	0.0556
p.G302D	DO234286	ESAD	ICGC	PSSTS	DEG_SPOP_SBC_1	304:308	Mutation rewiring degron network	0.2778
p.G302D	SIDM00808	Burkitt's Lymphoma	GDSC	PSSTS	DEG_SPOP_SBC_1	304:308	Mutation rewiring degron network	0.2778
p.S315C	DO48215	ESCA	ICGC	PSSTS	DEG_SPOP_SBC_1	304:308	Mutation rewiring degron network	0.1389
p.S258C	DO223079	ESCA	ICGC	APSST	DEG_SPOP_SBC_1	246:250	Mutation rewiring degron network	0.1111
p.M294L	DO233028	GACA	ICGC	PSSTS	DEG_SPOP_SBC_1	304:308	Mutation rewiring degron network	0.0556
p.S308F	DO228918	LICA	ICGC	PSSTS	DEG_SPOP_SBC_1	304:308	Mutation altering degron motif	0.7982
p.D301N	DO222749	MELA	ICGC	PSSTS	DEG_SPOP_SBC_1	304:308	Mutation rewiring degron network	0.25
p.E314K	DO222753	MELA	ICGC	PSSTS	DEG_SPOP_SBC_1	304:308	Mutation rewiring degron network	0.1667
p.G129R	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	VITSS	DEG_SPOP_SBC_1	124:128	Mutation rewiring degron network	0.3056
p.G129R	NCI-H23	lung	COSMIC	VITSS	DEG_SPOP_SBC_1	124:128	Mutation rewiring degron network	0.3056
p.S243F	SIDM01343	Gastric Carcinoma	GDSC	APSST	DEG_SPOP_SBC_1	246:250	Mutation rewiring degron network	0.25
p.P137H	ACH-000749	Lung Cancer	CCLE	VITSS	DEG_SPOP_SBC_1	124:128	Mutation rewiring degron network	0.0833
p.P137H	DMS-273	lung	COSMIC	VITSS	DEG_SPOP_SBC_1	124:128	Mutation rewiring degron network	0.0833
p.I128V	H-EMC-SS	bone	COSMIC	VITSS	DEG_SPOP_SBC_1	124:128	Mutation altering degron motif	0.7076
p.N298I	huH-1	liver	COSMIC	PSSTS	DEG_SPOP_SBC_1	304:308	Mutation rewiring degron network	0.1667
p.M306T	Ca-Ski	cervix	COSMIC	PSSTS	DEG_SPOP_SBC_1	304:308	Mutation altering degron motif	0.7423
p.Q257K	IST-SL1	lung	COSMIC	APSST	DEG_SPOP_SBC_1	246:250	Mutation rewiring degron network	0.1389
p.S116L	Sarc9371	bone	COSMIC	VITSS	DEG_SPOP_SBC_1	124:128	Mutation rewiring degron network	0.1111

Kaplan plot for EYA4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EYA4

UniProt ID: O95677

Entrez ID: 2070

Protein name: Eyes absent homolog 4 (EC 3.1.3.48)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for EYA4 in