DegronMD

Uniprot ID: O95677

Source protein: Eyes absent homolog 4

Source gene: EYA4

Class: DEG_SPOP_SBC_1

Location: 124:128

E3 ligase: SPOP

DEGRON score: 0.9997

ASA_SCORE: 70.4

COIL: 0.8224

CONS_SCORE: 0.363

DSS_SCORE: 0.4407

HELIX: 0.052

FCONS_SCORE: 1.0566

RIG_SCORE: 0.7136

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A116V	TCGA-A5-A2K3	UCEC	TCGA	VITSS	DEG_SPOP_SBC_1	0.1111
p.A116V	DO43899	UCEC	ICGC	VITSS	DEG_SPOP_SBC_1	0.1111
p.L117P	TCGA-CK-5916	COAD	TCGA	VITSS	DEG_SPOP_SBC_1	0.1389
p.L117P	DO8786	COAD	ICGC	VITSS	DEG_SPOP_SBC_1	0.1389
p.G122R	TCGA-GN-A8LK	SKCM	TCGA	VITSS	DEG_SPOP_SBC_1	0.2778
p.G122R	DO51259	SKCM	ICGC	VITSS	DEG_SPOP_SBC_1	0.2778
p.D114N	TCGA-HU-A4HD	STAD	TCGA	VITSS	DEG_SPOP_SBC_1	0.0556
p.D114N	DO47989	STAD	ICGC	VITSS	DEG_SPOP_SBC_1	0.0556
p.Y138H	DO225232	BRCA	ICGC	VITSS	DEG_SPOP_SBC_1	0.0556
p.G129R	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	VITSS	DEG_SPOP_SBC_1	0.3056
p.G129R	NCI-H23	lung	COSMIC	VITSS	DEG_SPOP_SBC_1	0.3056
p.P137H	ACH-000749	Lung Cancer	CCLE	VITSS	DEG_SPOP_SBC_1	0.0833
p.P137H	DMS-273	lung	COSMIC	VITSS	DEG_SPOP_SBC_1	0.0833
p.I128V	H-EMC-SS	bone	COSMIC	VITSS	DEG_SPOP_SBC_1	0.7076
p.S116L	Sarc9371	bone	COSMIC	VITSS	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00764	Pyridoxal kinase	DEG_SPOP_SBC_1	184:188	VITSS	SPOP	0.6795	More...
O75928	E3 SUMO-protein ligase PIAS2	DEG_SPOP_SBC_1	606:610	VITSS	SPOP	0.5785	More...
O95677	Eyes absent homolog 4	DEG_SPOP_SBC_1	124:128	VITSS	SPOP	0.9997	More...
P28324	ETS domain-containing protein Elk-4	DEG_SPOP_SBC_1	332:336	VITSS	SPOP	0.9963	More...
Q6GYQ0	Ral GTPase-activating protein subunit alpha-1	DEG_SPOP_SBC_1	456:460	VITSS	SPOP	0.9959	More...
Q6WRI0	Immunoglobulin superfamily member 10	DEG_SPOP_SBC_1	1176:1180	VITSS	SPOP	0.918	More...
Q8IZD4	mRNA-decapping enzyme 1B	DEG_SPOP_SBC_1	571:575	VITSS	SPOP	0.9737	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	5819:5823	VITSS	SPOP	0.9816	More...
Q9Y467	Sal-like protein 2	DEG_SPOP_SBC_1	444:448	VITSS	SPOP	0.9233	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons