DegronMD

Uniprot ID: O00764

Source protein: Pyridoxal kinase

Source gene: PDXK

Class: DEG_SPOP_SBC_1

Location: 184:188

E3 ligase: SPOP

DEGRON score: 0.6795

ASA_SCORE: 5.32

COIL: 0.133

CONS_SCORE: 0.5767

DSS_SCORE: 0.55

HELIX: 0.0076

FCONS_SCORE: 1.481

RIG_SCORE: 0.7599

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D181N	TCGA-AP-A0LM	UCEC	TCGA	VITSS	DEG_SPOP_SBC_1	0.25
p.D181N	DO43306	UCEC	ICGC	VITSS	DEG_SPOP_SBC_1	0.25
p.S188F	TCGA-UC-A7PG	CESC	TCGA	VITSS	DEG_SPOP_SBC_1	0.7982
p.T182I	TCGA-XK-AAIW	PRAD	TCGA	VITSS	DEG_SPOP_SBC_1	0.2778
p.T182I	DO51407	PRAD	ICGC	VITSS	DEG_SPOP_SBC_1	0.2778
p.V186L	DO229026	LICA	ICGC	VITSS	DEG_SPOP_SBC_1	0.6765
p.R178H	DO42177	UCEC	ICGC	VITSS	DEG_SPOP_SBC_1	0.1667
p.R178H	SK-UT-1	soft_tissue	COSMIC	VITSS	DEG_SPOP_SBC_1	0.1667
p.V189I	SNU-C2B	large_intestine	COSMIC	VITSS	DEG_SPOP_SBC_1	0.3056
p.R190H	SK-UT-1	soft_tissue	COSMIC	VITSS	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00764	Pyridoxal kinase	DEG_SPOP_SBC_1	184:188	VITSS	SPOP	0.6795	More...
O75928	E3 SUMO-protein ligase PIAS2	DEG_SPOP_SBC_1	606:610	VITSS	SPOP	0.5785	More...
O95677	Eyes absent homolog 4	DEG_SPOP_SBC_1	124:128	VITSS	SPOP	0.9997	More...
P28324	ETS domain-containing protein Elk-4	DEG_SPOP_SBC_1	332:336	VITSS	SPOP	0.9963	More...
Q6GYQ0	Ral GTPase-activating protein subunit alpha-1	DEG_SPOP_SBC_1	456:460	VITSS	SPOP	0.9959	More...
Q6WRI0	Immunoglobulin superfamily member 10	DEG_SPOP_SBC_1	1176:1180	VITSS	SPOP	0.918	More...
Q8IZD4	mRNA-decapping enzyme 1B	DEG_SPOP_SBC_1	571:575	VITSS	SPOP	0.9737	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	5819:5823	VITSS	SPOP	0.9816	More...
Q9Y467	Sal-like protein 2	DEG_SPOP_SBC_1	444:448	VITSS	SPOP	0.9233	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons