DegronMD - Q6WRI0(IGSF10)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S1179T	TCGA-13-0807	OV	TCGA	VITSS	DEG_SPOP_SBC_1	1176:1180	Mutation altering degron motif	0.6005
p.S1179T	DO28206	OV	ICGC	VITSS	DEG_SPOP_SBC_1	1176:1180	Mutation altering degron motif	0.6005
p.A801D	TCGA-14-1396	GBM	TCGA	LALHEE	LIG_APCC_ABBA_1	800:805	Mutation altering degron motif	0.6682
p.A801D	DO11429	GBM	ICGC	LALHEE	LIG_APCC_ABBA_1	800:805	Mutation altering degron motif	0.6682
p.V374L	TCGA-50-6594	LUAD	TCGA	LALYSD	LIG_APCC_ABBA_1	378:383	Mutation rewiring degron network	0.2222
p.V374L	DO24275	LUAD	ICGC	LALYSD	LIG_APCC_ABBA_1	378:383	Mutation rewiring degron network	0.2222
p.P373Q	TCGA-50-6594	LUAD	TCGA	LALYSD	LIG_APCC_ABBA_1	378:383	Mutation rewiring degron network	0.1944
p.P373Q	DO229009	LICA	ICGC	LALYSD	LIG_APCC_ABBA_1	378:383	Mutation rewiring degron network	0.1944
p.P373Q	DO24275	LUAD	ICGC	LALYSD	LIG_APCC_ABBA_1	378:383	Mutation rewiring degron network	0.1944
p.I2080M	TCGA-85-A4QQ	LUSC	TCGA	DSGHRT	DEG_SCF_TRCP1_1	2088:2093	Mutation rewiring degron network	0.1111
p.I2080M	DO45427	LUSC	ICGC	DSGHRT	DEG_SCF_TRCP1_1	2088:2093	Mutation rewiring degron network	0.1111
p.S1179L	TCGA-AA-3984	COAD	TCGA	VITSS	DEG_SPOP_SBC_1	1176:1180	Mutation altering degron motif	0.7667
p.S1179L	DO9002	COAD	ICGC	VITSS	DEG_SPOP_SBC_1	1176:1180	Mutation altering degron motif	0.7667
p.R2095I	TCGA-AG-3892	READ	TCGA	DSGHRT	DEG_SCF_TRCP1_1	2088:2093	Mutation rewiring degron network	0.2778
p.R2095I	DO36394	READ	ICGC	DSGHRT	DEG_SCF_TRCP1_1	2088:2093	Mutation rewiring degron network	0.2778
p.S384F	TCGA-AG-3892	READ	TCGA	LALYSD	LIG_APCC_ABBA_1	378:383	Mutation rewiring degron network	0.3056
p.S384F	DO36394	READ	ICGC	LALYSD	LIG_APCC_ABBA_1	378:383	Mutation rewiring degron network	0.3056
p.D2087N	TCGA-B5-A1MR	UCEC	TCGA	DSGHRT	DEG_SCF_TRCP1_1	2088:2093	Mutation rewiring degron network	0.3056
p.D2087N	TCGA-CA-6717	COAD	TCGA	DSGHRT	DEG_SCF_TRCP1_1	2088:2093	Mutation rewiring degron network	0.3056
p.D2087N	DO8264	COAD	ICGC	DSGHRT	DEG_SCF_TRCP1_1	2088:2093	Mutation rewiring degron network	0.3056
p.D2087N	DO41758	UCEC	ICGC	DSGHRT	DEG_SCF_TRCP1_1	2088:2093	Mutation rewiring degron network	0.3056
p.E804D	TCGA-BA-A6DA	HNSC	TCGA	LALHEE	LIG_APCC_ABBA_1	800:805	Mutation altering degron motif	0.5647
p.E804D	DO44448	HNSC	ICGC	LALHEE	LIG_APCC_ABBA_1	800:805	Mutation altering degron motif	0.5647
p.P809Q	TCGA-BG-A221	UCEC	TCGA	LALHEE	LIG_APCC_ABBA_1	800:805	Mutation rewiring degron network	0.2222
p.P809Q	DO42384	UCEC	ICGC	LALHEE	LIG_APCC_ABBA_1	800:805	Mutation rewiring degron network	0.2222
p.L380F	TCGA-BR-8289	STAD	TCGA	LALYSD	LIG_APCC_ABBA_1	378:383	Mutation altering degron motif	0.6981
p.L380F	DO38591	STAD	ICGC	LALYSD	LIG_APCC_ABBA_1	378:383	Mutation altering degron motif	0.6981
p.Q376H	TCGA-BR-8680	STAD	TCGA	LALYSD	LIG_APCC_ABBA_1	378:383	Mutation rewiring degron network	0.2778
p.Q376H	DO47769	STAD	ICGC	LALYSD	LIG_APCC_ABBA_1	378:383	Mutation rewiring degron network	0.2778
p.N2100K	TCGA-C5-A7XC	CESC	TCGA	DSGHRT	DEG_SCF_TRCP1_1	2088:2093	Mutation rewiring degron network	0.1389
p.N2100K	DO49896	CESC	ICGC	DSGHRT	DEG_SCF_TRCP1_1	2088:2093	Mutation rewiring degron network	0.1389
p.N2100S	TCGA-D1-A17Q	UCEC	TCGA	DSGHRT	DEG_SCF_TRCP1_1	2088:2093	Mutation rewiring degron network	0.1389
p.N2100S	DO41903	UCEC	ICGC	DSGHRT	DEG_SCF_TRCP1_1	2088:2093	Mutation rewiring degron network	0.1389
p.M1190I	TCGA-DK-A6AW	BLCA	TCGA	VITSS	DEG_SPOP_SBC_1	1176:1180	Mutation rewiring degron network	0.0556
p.M1190I	DO48566	BLCA	ICGC	VITSS	DEG_SPOP_SBC_1	1176:1180	Mutation rewiring degron network	0.0556
p.A801T	TCGA-E6-A1LX	UCEC	TCGA	LALHEE	LIG_APCC_ABBA_1	800:805	Mutation altering degron motif	0.6028
p.A801T	TCGA-F5-6814	READ	TCGA	LALHEE	LIG_APCC_ABBA_1	800:805	Mutation altering degron motif	0.6028
p.A801T	DO234230	ESAD	ICGC	LALHEE	LIG_APCC_ABBA_1	800:805	Mutation altering degron motif	0.6028
p.A801T	DO36556	READ	ICGC	LALHEE	LIG_APCC_ABBA_1	800:805	Mutation altering degron motif	0.6028
p.A801T	DO41020	UCEC	ICGC	LALHEE	LIG_APCC_ABBA_1	800:805	Mutation altering degron motif	0.6028
p.A801T	SIDM00217	Colorectal Carcinoma	GDSC	LALHEE	LIG_APCC_ABBA_1	800:805	Mutation altering degron motif	0.6028
p.A801T	SIDM00534	Colorectal Carcinoma	GDSC	LALHEE	LIG_APCC_ABBA_1	800:805	Mutation altering degron motif	0.6028
p.A801T	ACH-000986	Colon/Colorectal Cancer	CCLE	LALHEE	LIG_APCC_ABBA_1	800:805	Mutation altering degron motif	0.6028
p.A801T	ACH-000999	Colon/Colorectal Cancer	CCLE	LALHEE	LIG_APCC_ABBA_1	800:805	Mutation altering degron motif	0.6028
p.A801T	SNU-1040	large intestine	COSMIC	LALHEE	LIG_APCC_ABBA_1	800:805	Mutation altering degron motif	0.6028
p.A801T	HT-115	large intestine	COSMIC	LALHEE	LIG_APCC_ABBA_1	800:805	Mutation altering degron motif	0.6028
p.T1178A	TCGA-FD-A6TD	BLCA	TCGA	VITSS	DEG_SPOP_SBC_1	1176:1180	Mutation altering degron motif	0.7139
p.T1178A	DO49757	BLCA	ICGC	VITSS	DEG_SPOP_SBC_1	1176:1180	Mutation altering degron motif	0.7139
p.D795A	TCGA-FS-A1YW	SKCM	TCGA	LALHEE	LIG_APCC_ABBA_1	800:805	Mutation rewiring degron network	0.1944
p.D795A	DO37734	SKCM	ICGC	LALHEE	LIG_APCC_ABBA_1	800:805	Mutation rewiring degron network	0.1944
p.E1170K	TCGA-FW-A3R5	SKCM	TCGA	VITSS	DEG_SPOP_SBC_1	1176:1180	Mutation rewiring degron network	0.1667
p.E1170K	DO37406	SKCM	ICGC	VITSS	DEG_SPOP_SBC_1	1176:1180	Mutation rewiring degron network	0.1667
p.E805K	TCGA-GN-A4U4	SKCM	TCGA	LALHEE	LIG_APCC_ABBA_1	800:805	Mutation altering degron motif	0.7022
p.E805K	DO220856	MELA	ICGC	LALHEE	LIG_APCC_ABBA_1	800:805	Mutation altering degron motif	0.7022
p.E805K	DO51256	SKCM	ICGC	LALHEE	LIG_APCC_ABBA_1	800:805	Mutation altering degron motif	0.7022
p.S382T	TCGA-Q1-A73O	CESC	TCGA	LALYSD	LIG_APCC_ABBA_1	378:383	Mutation altering degron motif	0.6005
p.S382T	DO51612	CESC	ICGC	LALYSD	LIG_APCC_ABBA_1	378:383	Mutation altering degron motif	0.6005
p.P809S	TCGA-W3-AA1V	SKCM	TCGA	LALHEE	LIG_APCC_ABBA_1	800:805	Mutation rewiring degron network	0.2222
p.P809S	DO51276	SKCM	ICGC	LALHEE	LIG_APCC_ABBA_1	800:805	Mutation rewiring degron network	0.2222
p.D383N	DO218173	BRCA	ICGC	LALYSD	LIG_APCC_ABBA_1	378:383	Mutation altering degron motif	0.6932
p.M1190K	DO6358	CLLE	ICGC	VITSS	DEG_SPOP_SBC_1	1176:1180	Mutation rewiring degron network	0.0556
p.A1171D	DO229029	LICA	ICGC	VITSS	DEG_SPOP_SBC_1	1176:1180	Mutation rewiring degron network	0.1944
p.A2083E	DO229027	LICA	ICGC	DSGHRT	DEG_SCF_TRCP1_1	2088:2093	Mutation rewiring degron network	0.1944
p.P790T	DO229031	LICA	ICGC	LALHEE	LIG_APCC_ABBA_1	800:805	Mutation rewiring degron network	0.0556
p.S1167N	DO231075	LUSC	ICGC	VITSS	DEG_SPOP_SBC_1	1176:1180	Mutation blocking phosphorylation signal	0.5278
p.N815I	SIDM01298	Esophageal Carcinoma	GDSC	LALHEE	LIG_APCC_ABBA_1	800:805	Mutation rewiring degron network	0.0556
p.N2082S	SIDM00672	Hepatocellular Carcinoma	GDSC	DSGHRT	DEG_SCF_TRCP1_1	2088:2093	Mutation rewiring degron network	0.1667
p.A379D	SIDM00946	T-Lymphoblastic Leukemia	GDSC	LALYSD	LIG_APCC_ABBA_1	378:383	Mutation altering degron motif	0.6682
p.A379D	ACH-000981	Leukemia	CCLE	LALYSD	LIG_APCC_ABBA_1	378:383	Mutation altering degron motif	0.6682
p.A379D	DND-41	haematopoietic and lymphoid tissue	COSMIC	LALYSD	LIG_APCC_ABBA_1	378:383	Mutation altering degron motif	0.6682
p.N815D	SIDM00216	Colorectal Carcinoma	GDSC	LALHEE	LIG_APCC_ABBA_1	800:805	Mutation rewiring degron network	0.0556
p.N815D	ACH-000989	Colon/Colorectal Cancer	CCLE	LALHEE	LIG_APCC_ABBA_1	800:805	Mutation rewiring degron network	0.0556
p.N815D	SNU-175	large intestine	COSMIC	LALHEE	LIG_APCC_ABBA_1	800:805	Mutation rewiring degron network	0.0556
p.D795N	SIDM00393	Gastric Carcinoma	GDSC	LALHEE	LIG_APCC_ABBA_1	800:805	Mutation rewiring degron network	0.1944
p.D795N	SIDM01002	Breast Carcinoma	GDSC	LALHEE	LIG_APCC_ABBA_1	800:805	Mutation rewiring degron network	0.1944
p.D795N	SIDM00254	Neuroblastoma	GDSC	LALHEE	LIG_APCC_ABBA_1	800:805	Mutation rewiring degron network	0.1944
p.D795N	SIDM00721	Small Cell Lung Carcinoma	GDSC	LALHEE	LIG_APCC_ABBA_1	800:805	Mutation rewiring degron network	0.1944
p.G369S	SIDM00364	B-Lymphoblastic Leukemia	GDSC	LALYSD	LIG_APCC_ABBA_1	378:383	Mutation rewiring degron network	0.0833
p.G369S	ACH-002059	Leukemia	CCLE	LALYSD	LIG_APCC_ABBA_1	378:383	Mutation rewiring degron network	0.0833
p.G369S	P30-OHK	haematopoietic and lymphoid tissue	COSMIC	LALYSD	LIG_APCC_ABBA_1	378:383	Mutation rewiring degron network	0.0833
p.R2095S	SIDM00282	Colorectal Carcinoma	GDSC	DSGHRT	DEG_SCF_TRCP1_1	2088:2093	Mutation rewiring degron network	0.2778
p.R2095S	ACH-000998	Colon/Colorectal Cancer	CCLE	DSGHRT	DEG_SCF_TRCP1_1	2088:2093	Mutation rewiring degron network	0.2778
p.R2095S	CW-2	large intestine	COSMIC	DSGHRT	DEG_SCF_TRCP1_1	2088:2093	Mutation rewiring degron network	0.2778
p.H803N	SIDM00710	Small Cell Lung Carcinoma	GDSC	LALHEE	LIG_APCC_ABBA_1	800:805	Mutation altering degron motif	0.7423
p.H803N	ACH-000394	Lung Cancer	CCLE	LALHEE	LIG_APCC_ABBA_1	800:805	Mutation altering degron motif	0.7423
p.H803N	NCI-H2081	lung	COSMIC	LALHEE	LIG_APCC_ABBA_1	800:805	Mutation altering degron motif	0.7423
p.P1189Q	ACH-001645	Skin Cancer	CCLE	VITSS	DEG_SPOP_SBC_1	1176:1180	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

IGSF10

UniProt ID: Q6WRI0

Entrez ID: 285313

Protein name: Immunoglobulin superfamily member 10 (IgSF10) (Calvaria mechanical force protein 608) (CMF608)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for IGSF10 in