DegronMD

Uniprot ID: Q6WRI0

Source protein: Immunoglobulin superfamily member 10

Source gene: IGSF10

Class: LIG_APCC_ABBA_1

Location: 378:383

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5422

ASA_SCORE: 48.2333

COIL: 0.4568

CONS_SCORE: 0.6386

DSS_SCORE: 0.0173

HELIX: 0.0202

FCONS_SCORE: 1.1834

RIG_SCORE: 0.9238

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V374L	TCGA-50-6594	LUAD	TCGA	LALYSD	LIG_APCC_ABBA_1	0.2222
p.V374L	DO24275	LUAD	ICGC	LALYSD	LIG_APCC_ABBA_1	0.2222
p.P373Q	TCGA-50-6594	LUAD	TCGA	LALYSD	LIG_APCC_ABBA_1	0.1944
p.P373Q	DO229009	LICA	ICGC	LALYSD	LIG_APCC_ABBA_1	0.1944
p.P373Q	DO24275	LUAD	ICGC	LALYSD	LIG_APCC_ABBA_1	0.1944
p.S384F	TCGA-AG-3892	READ	TCGA	LALYSD	LIG_APCC_ABBA_1	0.3056
p.S384F	DO36394	READ	ICGC	LALYSD	LIG_APCC_ABBA_1	0.3056
p.L380F	TCGA-BR-8289	STAD	TCGA	LALYSD	LIG_APCC_ABBA_1	0.6981
p.L380F	DO38591	STAD	ICGC	LALYSD	LIG_APCC_ABBA_1	0.6981
p.Q376H	TCGA-BR-8680	STAD	TCGA	LALYSD	LIG_APCC_ABBA_1	0.2778
p.Q376H	DO47769	STAD	ICGC	LALYSD	LIG_APCC_ABBA_1	0.2778
p.S382T	TCGA-Q1-A73O	CESC	TCGA	LALYSD	LIG_APCC_ABBA_1	0.6005
p.S382T	DO51612	CESC	ICGC	LALYSD	LIG_APCC_ABBA_1	0.6005
p.D383N	DO218173	BRCA	ICGC	LALYSD	LIG_APCC_ABBA_1	0.6932
p.A379D	SIDM00946	T-Lymphoblastic Leukemia	GDSC	LALYSD	LIG_APCC_ABBA_1	0.6682
p.A379D	ACH-000981	Leukemia	CCLE	LALYSD	LIG_APCC_ABBA_1	0.6682
p.A379D	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	LALYSD	LIG_APCC_ABBA_1	0.6682
p.G369S	SIDM00364	B-Lymphoblastic Leukemia	GDSC	LALYSD	LIG_APCC_ABBA_1	0.0833
p.G369S	ACH-002059	Leukemia	CCLE	LALYSD	LIG_APCC_ABBA_1	0.0833
p.G369S	P30-OHK	haematopoietic_and_lymphoid_tissue	COSMIC	LALYSD	LIG_APCC_ABBA_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6WRI0	Immunoglobulin superfamily member 10	LIG_APCC_ABBA_1	378:383	LALYSD	APC,CDC20,FZR1	0.5422	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons