DegronMD

Uniprot ID: Q6WRI0

Source protein: Immunoglobulin superfamily member 10

Source gene: IGSF10

Class: LIG_APCC_ABBA_1

Location: 800:805

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.734

ASA_SCORE: 80.5

COIL: 0.5603

CONS_SCORE: 0.3518

DSS_SCORE: 0.5108

HELIX: 0.052

FCONS_SCORE: 1.1041

RIG_SCORE: 0.7876

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A801D	TCGA-14-1396	GBM	TCGA	LALHEE	LIG_APCC_ABBA_1	0.6682
p.A801D	DO11429	GBM	ICGC	LALHEE	LIG_APCC_ABBA_1	0.6682
p.E804D	TCGA-BA-A6DA	HNSC	TCGA	LALHEE	LIG_APCC_ABBA_1	0.5647
p.E804D	DO44448	HNSC	ICGC	LALHEE	LIG_APCC_ABBA_1	0.5647
p.P809Q	TCGA-BG-A221	UCEC	TCGA	LALHEE	LIG_APCC_ABBA_1	0.2222
p.P809Q	DO42384	UCEC	ICGC	LALHEE	LIG_APCC_ABBA_1	0.2222
p.A801T	TCGA-E6-A1LX	UCEC	TCGA	LALHEE	LIG_APCC_ABBA_1	0.6028
p.A801T	TCGA-F5-6814	READ	TCGA	LALHEE	LIG_APCC_ABBA_1	0.6028
p.A801T	DO234230	ESAD	ICGC	LALHEE	LIG_APCC_ABBA_1	0.6028
p.A801T	DO36556	READ	ICGC	LALHEE	LIG_APCC_ABBA_1	0.6028
p.A801T	DO41020	UCEC	ICGC	LALHEE	LIG_APCC_ABBA_1	0.6028
p.A801T	SIDM00217	Colorectal Carcinoma	GDSC	LALHEE	LIG_APCC_ABBA_1	0.6028
p.A801T	SIDM00534	Colorectal Carcinoma	GDSC	LALHEE	LIG_APCC_ABBA_1	0.6028
p.A801T	ACH-000986	Colon/Colorectal Cancer	CCLE	LALHEE	LIG_APCC_ABBA_1	0.6028
p.A801T	ACH-000999	Colon/Colorectal Cancer	CCLE	LALHEE	LIG_APCC_ABBA_1	0.6028
p.A801T	SNU-1040	large_intestine	COSMIC	LALHEE	LIG_APCC_ABBA_1	0.6028
p.A801T	HT-115	large_intestine	COSMIC	LALHEE	LIG_APCC_ABBA_1	0.6028
p.D795A	TCGA-FS-A1YW	SKCM	TCGA	LALHEE	LIG_APCC_ABBA_1	0.1944
p.D795A	DO37734	SKCM	ICGC	LALHEE	LIG_APCC_ABBA_1	0.1944
p.E805K	TCGA-GN-A4U4	SKCM	TCGA	LALHEE	LIG_APCC_ABBA_1	0.7022
p.E805K	DO220856	MELA	ICGC	LALHEE	LIG_APCC_ABBA_1	0.7022
p.E805K	DO51256	SKCM	ICGC	LALHEE	LIG_APCC_ABBA_1	0.7022
p.P809S	TCGA-W3-AA1V	SKCM	TCGA	LALHEE	LIG_APCC_ABBA_1	0.2222
p.P809S	DO51276	SKCM	ICGC	LALHEE	LIG_APCC_ABBA_1	0.2222
p.P790T	DO229031	LICA	ICGC	LALHEE	LIG_APCC_ABBA_1	0.0556
p.N815I	SIDM01298	Esophageal Carcinoma	GDSC	LALHEE	LIG_APCC_ABBA_1	0.0556
p.N815D	SIDM00216	Colorectal Carcinoma	GDSC	LALHEE	LIG_APCC_ABBA_1	0.0556
p.N815D	ACH-000989	Colon/Colorectal Cancer	CCLE	LALHEE	LIG_APCC_ABBA_1	0.0556
p.N815D	SNU-175	large_intestine	COSMIC	LALHEE	LIG_APCC_ABBA_1	0.0556
p.D795N	SIDM00393	Gastric Carcinoma	GDSC	LALHEE	LIG_APCC_ABBA_1	0.1944
p.D795N	SIDM01002	Breast Carcinoma	GDSC	LALHEE	LIG_APCC_ABBA_1	0.1944
p.D795N	SIDM00254	Neuroblastoma	GDSC	LALHEE	LIG_APCC_ABBA_1	0.1944
p.D795N	SIDM00721	Small Cell Lung Carcinoma	GDSC	LALHEE	LIG_APCC_ABBA_1	0.1944
p.H803N	SIDM00710	Small Cell Lung Carcinoma	GDSC	LALHEE	LIG_APCC_ABBA_1	0.7423
p.H803N	ACH-000394	Lung Cancer	CCLE	LALHEE	LIG_APCC_ABBA_1	0.7423
p.H803N	NCI-H2081	lung	COSMIC	LALHEE	LIG_APCC_ABBA_1	0.7423

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LALHEE

Degron related mutations and impact score

Drug responses associated with IGSF10 mutations

All proteins holding degron of LALHEE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6WRI0	Immunoglobulin superfamily member 10	LIG_APCC_ABBA_1	800:805	LALHEE	APC,CDC20,FZR1	0.734	More...