DegronMD

Uniprot ID: Q6WRI0

Source protein: Immunoglobulin superfamily member 10

Source gene: IGSF10

Class: DEG_SPOP_SBC_1

Location: 1176:1180

E3 ligase: SPOP

DEGRON score: 0.918

ASA_SCORE: 64.9

COIL: 0.2968

CONS_SCORE: 0.2882

DSS_SCORE: 0.4596

HELIX: 0.012

FCONS_SCORE: 1.0187

RIG_SCORE: 0.7494

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1179T	TCGA-13-0807	OV	TCGA	VITSS	DEG_SPOP_SBC_1	0.6005
p.S1179T	DO28206	OV	ICGC	VITSS	DEG_SPOP_SBC_1	0.6005
p.S1179L	TCGA-AA-3984	COAD	TCGA	VITSS	DEG_SPOP_SBC_1	0.7667
p.S1179L	DO9002	COAD	ICGC	VITSS	DEG_SPOP_SBC_1	0.7667
p.M1190I	TCGA-DK-A6AW	BLCA	TCGA	VITSS	DEG_SPOP_SBC_1	0.0556
p.M1190I	DO48566	BLCA	ICGC	VITSS	DEG_SPOP_SBC_1	0.0556
p.T1178A	TCGA-FD-A6TD	BLCA	TCGA	VITSS	DEG_SPOP_SBC_1	0.7139
p.T1178A	DO49757	BLCA	ICGC	VITSS	DEG_SPOP_SBC_1	0.7139
p.E1170K	TCGA-FW-A3R5	SKCM	TCGA	VITSS	DEG_SPOP_SBC_1	0.1667
p.E1170K	DO37406	SKCM	ICGC	VITSS	DEG_SPOP_SBC_1	0.1667
p.M1190K	DO6358	CLLE	ICGC	VITSS	DEG_SPOP_SBC_1	0.0556
p.A1171D	DO229029	LICA	ICGC	VITSS	DEG_SPOP_SBC_1	0.1944
p.S1167N	DO231075	LUSC	ICGC	VITSS	DEG_SPOP_SBC_1	0.5278
p.P1189Q	ACH-001645	Skin Cancer	CCLE	VITSS	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00764	Pyridoxal kinase	DEG_SPOP_SBC_1	184:188	VITSS	SPOP	0.6795	More...
O75928	E3 SUMO-protein ligase PIAS2	DEG_SPOP_SBC_1	606:610	VITSS	SPOP	0.5785	More...
O95677	Eyes absent homolog 4	DEG_SPOP_SBC_1	124:128	VITSS	SPOP	0.9997	More...
P28324	ETS domain-containing protein Elk-4	DEG_SPOP_SBC_1	332:336	VITSS	SPOP	0.9963	More...
Q6GYQ0	Ral GTPase-activating protein subunit alpha-1	DEG_SPOP_SBC_1	456:460	VITSS	SPOP	0.9959	More...
Q6WRI0	Immunoglobulin superfamily member 10	DEG_SPOP_SBC_1	1176:1180	VITSS	SPOP	0.918	More...
Q8IZD4	mRNA-decapping enzyme 1B	DEG_SPOP_SBC_1	571:575	VITSS	SPOP	0.9737	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	5819:5823	VITSS	SPOP	0.9816	More...
Q9Y467	Sal-like protein 2	DEG_SPOP_SBC_1	444:448	VITSS	SPOP	0.9233	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons