DegronMD - Q8IZD4(DCP1B)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P505L	TCGA-2W-A8YY	CESC	TCGA	INKTPNTE	DEG_SCF_FBW7_2	494:501	Mutation rewiring degron network	0.2222
p.T486I	TCGA-90-7769	LUSC	TCGA	INKTPNTE	DEG_SCF_FBW7_2	494:501	Mutation rewiring degron network	0.1111
p.I564V	TCGA-AD-6964	COAD	TCGA	VITSS	DEG_SPOP_SBC_1	571:575	Mutation rewiring degron network	0.1389
p.N499S	TCGA-AP-A1DK	UCEC	TCGA	INKTPNTE	DEG_SCF_FBW7_2	494:501	Mutation altering degron motif	0.5958
p.A509E	DO228976	LICA	ICGC	INKTPNTE	DEG_SCF_FBW7_2	494:501	Mutation rewiring degron network	0.1111
p.A509E	DO50725	ORCA	ICGC	INKTPNTE	DEG_SCF_FBW7_2	494:501	Mutation rewiring degron network	0.1111
p.T507N	DO229026	LICA	ICGC	INKTPNTE	DEG_SCF_FBW7_2	494:501	Mutation rewiring degron network	0.1667
p.I497V	DO26596	LUSC	ICGC	INKTPNTE	DEG_SCF_FBW7_2	494:501	Mutation altering degron motif	0.7076
p.V571M	SIDM02050	Colorectal Carcinoma	GDSC	VITSS	DEG_SPOP_SBC_1	571:575	Mutation altering degron motif	0.7208
p.Q583R	SIDM00162	Biliary Tract Carcinoma	GDSC	VITSS	DEG_SPOP_SBC_1	571:575	Mutation rewiring degron network	0.1111
p.Q583R	ACH-000268	Bile Duct Cancer	CCLE	VITSS	DEG_SPOP_SBC_1	571:575	Mutation rewiring degron network	0.1111

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons