DegronMD

Uniprot ID: Q8IZD4

Source protein: mRNA-decapping enzyme 1B

Source gene: DCP1B

Class: DEG_SCF_FBW7_2

Location: 494:501

E3 ligase: FBXW7

DEGRON score: 0.9905

ASA_SCORE: 92.1625

COIL: 0.8236

CONS_SCORE: 0.4045

DSS_SCORE: 0.5549

HELIX: 0.1474

FCONS_SCORE: 0.9649

RIG_SCORE: 0.7251

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P505L	TCGA-2W-A8YY	CESC	TCGA	INKTPNTE	DEG_SCF_FBW7_2	0.2222
p.T486I	TCGA-90-7769	LUSC	TCGA	INKTPNTE	DEG_SCF_FBW7_2	0.1111
p.N499S	TCGA-AP-A1DK	UCEC	TCGA	INKTPNTE	DEG_SCF_FBW7_2	0.5958
p.A509E	DO228976	LICA	ICGC	INKTPNTE	DEG_SCF_FBW7_2	0.1111
p.A509E	DO50725	ORCA	ICGC	INKTPNTE	DEG_SCF_FBW7_2	0.1111
p.T507N	DO229026	LICA	ICGC	INKTPNTE	DEG_SCF_FBW7_2	0.1667
p.I497V	DO26596	LUSC	ICGC	INKTPNTE	DEG_SCF_FBW7_2	0.7076

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IZD4	mRNA-decapping enzyme 1B	DEG_SCF_FBW7_2	494:501	INKTPNTE	FBXW7	0.9905	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons