DegronMD

Uniprot ID: Q8IZD4

Source protein: mRNA-decapping enzyme 1B

Source gene: DCP1B

Class: DEG_SPOP_SBC_1

Location: 571:575

E3 ligase: SPOP

DEGRON score: 0.9737

ASA_SCORE: 80.3

COIL: 0.9422

CONS_SCORE: 0.4291

DSS_SCORE: 0.3335

HELIX: 0.0212

FCONS_SCORE: 0.9578

RIG_SCORE: 0.7415

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I564V	TCGA-AD-6964	COAD	TCGA	VITSS	DEG_SPOP_SBC_1	0.1389
p.V571M	SIDM02050	Colorectal Carcinoma	GDSC	VITSS	DEG_SPOP_SBC_1	0.7208
p.Q583R	SIDM00162	Biliary Tract Carcinoma	GDSC	VITSS	DEG_SPOP_SBC_1	0.1111
p.Q583R	ACH-000268	Bile Duct Cancer	CCLE	VITSS	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00764	Pyridoxal kinase	DEG_SPOP_SBC_1	184:188	VITSS	SPOP	0.6795	More...
O75928	E3 SUMO-protein ligase PIAS2	DEG_SPOP_SBC_1	606:610	VITSS	SPOP	0.5785	More...
O95677	Eyes absent homolog 4	DEG_SPOP_SBC_1	124:128	VITSS	SPOP	0.9997	More...
P28324	ETS domain-containing protein Elk-4	DEG_SPOP_SBC_1	332:336	VITSS	SPOP	0.9963	More...
Q6GYQ0	Ral GTPase-activating protein subunit alpha-1	DEG_SPOP_SBC_1	456:460	VITSS	SPOP	0.9959	More...
Q6WRI0	Immunoglobulin superfamily member 10	DEG_SPOP_SBC_1	1176:1180	VITSS	SPOP	0.918	More...
Q8IZD4	mRNA-decapping enzyme 1B	DEG_SPOP_SBC_1	571:575	VITSS	SPOP	0.9737	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	5819:5823	VITSS	SPOP	0.9816	More...
Q9Y467	Sal-like protein 2	DEG_SPOP_SBC_1	444:448	VITSS	SPOP	0.9233	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons