DegronMD - P28324(ELK4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G103C	TCGA-66-2727	LUSC	TCGA	VSSSS	DEG_SPOP_SBC_1	113:117	Mutation rewiring degron network	0.0556
p.G103C	DO26478	LUSC	ICGC	VSSSS	DEG_SPOP_SBC_1	113:117	Mutation rewiring degron network	0.0556
p.S136F	TCGA-69-7979	LUAD	TCGA	AKTSS	DEG_SPOP_SBC_1	133:137	Mutation altering degron motif	0.7982
p.S136F	DO23874	LUAD	ICGC	AKTSS	DEG_SPOP_SBC_1	133:137	Mutation altering degron motif	0.7982
p.G123A	TCGA-73-4658	LUAD	TCGA	VSSSS	DEG_SPOP_SBC_1	113:117	Mutation rewiring degron network	0.1667
p.G123A	TCGA-73-4658	LUAD	TCGA	AKTSS	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.0556
p.G123A	DO23663	LUAD	ICGC	VSSSS	DEG_SPOP_SBC_1	113:117	Mutation rewiring degron network	0.1667
p.G123A	DO23663	LUAD	ICGC	AKTSS	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.0556
p.I333T	TCGA-BK-A13B	UCEC	TCGA	VITSS	DEG_SPOP_SBC_1	332:336	Mutation altering degron motif	0.5966
p.I333T	DO40825	UCEC	ICGC	VITSS	DEG_SPOP_SBC_1	332:336	Mutation altering degron motif	0.5966
p.P329S	TCGA-BR-4201	STAD	TCGA	VITSS	DEG_SPOP_SBC_1	332:336	Mutation rewiring degron network	0.25
p.P329S	DO38707	STAD	ICGC	VITSS	DEG_SPOP_SBC_1	332:336	Mutation rewiring degron network	0.25
p.S136Y	TCGA-G2-A2EO	BLCA	TCGA	AKTSS	DEG_SPOP_SBC_1	133:137	Mutation altering degron motif	0.712
p.S136Y	DO456	BLCA	ICGC	AKTSS	DEG_SPOP_SBC_1	133:137	Mutation altering degron motif	0.712
p.Q130E	TCGA-XF-AAMG	BLCA	TCGA	AKTSS	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.25
p.Q130E	DO219049	BLCA	ICGC	AKTSS	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.25
p.A133D	DO229009	LICA	ICGC	AKTSS	DEG_SPOP_SBC_1	133:137	Mutation altering degron motif	0.7793
p.N109D	ACH-001786	Colon/Colorectal Cancer	CCLE	VSSSS	DEG_SPOP_SBC_1	113:117	Mutation rewiring degron network	0.2222

Kaplan plot for ELK4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ELK4

UniProt ID: P28324

Entrez ID: 2005

Protein name: ETS domain-containing protein Elk-4 (Serum response factor accessory protein 1) (SAP-1) (SRF accessory protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ELK4 in