DegronMD

Uniprot ID: P28324

Source protein: ETS domain-containing protein Elk-4

Source gene: ELK4

Class: DEG_SPOP_SBC_1

Location: 133:137

E3 ligase: SPOP

DEGRON score: 0.947

ASA_SCORE: 67.8

COIL: 0.8158

CONS_SCORE: 0.5005

DSS_SCORE: 0.6378

HELIX: 0.1008

FCONS_SCORE: 1.213

RIG_SCORE: 0.6197

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S136F	TCGA-69-7979	LUAD	TCGA	AKTSS	DEG_SPOP_SBC_1	0.7982
p.S136F	DO23874	LUAD	ICGC	AKTSS	DEG_SPOP_SBC_1	0.7982
p.G123A	TCGA-73-4658	LUAD	TCGA	AKTSS	DEG_SPOP_SBC_1	0.0556
p.G123A	DO23663	LUAD	ICGC	AKTSS	DEG_SPOP_SBC_1	0.0556
p.S136Y	TCGA-G2-A2EO	BLCA	TCGA	AKTSS	DEG_SPOP_SBC_1	0.712
p.S136Y	DO456	BLCA	ICGC	AKTSS	DEG_SPOP_SBC_1	0.712
p.Q130E	TCGA-XF-AAMG	BLCA	TCGA	AKTSS	DEG_SPOP_SBC_1	0.25
p.Q130E	DO219049	BLCA	ICGC	AKTSS	DEG_SPOP_SBC_1	0.25
p.A133D	DO229009	LICA	ICGC	AKTSS	DEG_SPOP_SBC_1	0.7793

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14578	Citron Rho-interacting kinase	DEG_SPOP_SBC_1	442:446	AKTSS	SPOP	0.8991	More...
P28324	ETS domain-containing protein Elk-4	DEG_SPOP_SBC_1	133:137	AKTSS	SPOP	0.947	More...
P49023	Paxillin	DEG_SPOP_SBC_1	92:96	AKTSS	SPOP	0.9674	More...
Q6PIL6	Kv channel-interacting protein 4	DEG_SPOP_SBC_1	46:50	AKTSS	SPOP	0.5322	More...
Q96CB8	Integrator complex subunit 12	DEG_SPOP_SBC_1	298:302	AKTSS	SPOP	0.6377	More...
Q9UKK3	Protein mono-ADP-ribosyltransferase PARP4	DEG_SPOP_SBC_1	603:607	AKTSS	SPOP	0.5644	More...
Q9ULD9	Zinc finger protein 608	DEG_SPOP_SBC_1	932:936	AKTSS	SPOP	0.9688	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons