DegronMD - O14578(CIT)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K454E	TCGA-4Z-AA7O	BLCA	TCGA	AKTSS	DEG_SPOP_SBC_1	442:446	Mutation substituting flanking lysine	0.2222
p.K454E	DO51865	BLCA	ICGC	AKTSS	DEG_SPOP_SBC_1	442:446	Mutation substituting flanking lysine	0.2222
p.A1928V	TCGA-4Z-AA80	BLCA	TCGA	PPTY	ITCH	1926:1929	Mutation altering degron motif	0.6936
p.R2002L	TCGA-56-7823	LUSC	TCGA	VRTPLSQVN	DEG_APCC_DBOX_1	2011:2019	Mutation blocking phosphorylation signal	0.5278
p.R2009L	TCGA-78-7149	LUAD	TCGA	VRTPLSQVN	DEG_APCC_DBOX_1	2011:2019	Mutation rewiring degron network	0.2778
p.S445C	TCGA-85-7699	LUSC	TCGA	AKTSS	DEG_SPOP_SBC_1	442:446	Mutation altering degron motif	0.7541
p.S445C	DO26534	LUSC	ICGC	AKTSS	DEG_SPOP_SBC_1	442:446	Mutation altering degron motif	0.7541
p.R2016H	TCGA-86-8055	LUAD	TCGA	VRTPLSQVN	DEG_APCC_DBOX_1	2011:2019	Mutation altering degron motif	0.8244
p.R2016C	TCGA-AJ-A3BH	UCEC	TCGA	VRTPLSQVN	DEG_APCC_DBOX_1	2011:2019	Mutation altering degron motif	0.8301
p.R2016C	ACH-000961	Endometrial/Uterine Cancer	CCLE	VRTPLSQVN	DEG_APCC_DBOX_1	2011:2019	Mutation altering degron motif	0.8301
p.P441H	TCGA-BW-A5NO	LIHC	TCGA	AKTSS	DEG_SPOP_SBC_1	442:446	Mutation rewiring degron network	0.3056
p.P441H	DO52171	LIHC	ICGC	AKTSS	DEG_SPOP_SBC_1	442:446	Mutation rewiring degron network	0.3056
p.L2008V	TCGA-CG-4437	STAD	TCGA	VRTPLSQVN	DEG_APCC_DBOX_1	2011:2019	Mutation rewiring degron network	0.25
p.V434A	TCGA-CV-A460	HNSC	TCGA	AKTSS	DEG_SPOP_SBC_1	442:446	Mutation rewiring degron network	0.1111
p.V434A	DO52065	HNSC	ICGC	AKTSS	DEG_SPOP_SBC_1	442:446	Mutation rewiring degron network	0.1111
p.A1919D	TCGA-EA-A411	CESC	TCGA	PPTY	ITCH	1926:1929	Mutation rewiring degron network	0.1389
p.S446F	TCGA-EE-A2GD	SKCM	TCGA	AKTSS	DEG_SPOP_SBC_1	442:446	Mutation altering degron motif	0.7982
p.S446F	DO37603	SKCM	ICGC	AKTSS	DEG_SPOP_SBC_1	442:446	Mutation altering degron motif	0.7982
p.R2009C	TCGA-EO-A22U	UCEC	TCGA	VRTPLSQVN	DEG_APCC_DBOX_1	2011:2019	Mutation rewiring degron network	0.2778
p.R2009C	ACH-000971	Colon/Colorectal Cancer	CCLE	VRTPLSQVN	DEG_APCC_DBOX_1	2011:2019	Mutation rewiring degron network	0.2778
p.R2002H	TCGA-EY-A549	UCEC	TCGA	VRTPLSQVN	DEG_APCC_DBOX_1	2011:2019	Mutation blocking phosphorylation signal	0.5278
p.P1926L	DO2198	BRCA	ICGC	PPTY	ITCH	1926:1929	Mutation altering degron motif	0.7582
p.A2008T	DO227987	COCA	ICGC	VRTPLSQVN	DEG_APCC_DBOX_1	2011:2019	Mutation rewiring degron network	0.25
p.K450T	DO222884	COCA	ICGC	AKTSS	DEG_SPOP_SBC_1	442:446	Mutation substituting flanking lysine	0.3333
p.Y1929H	DO233885	GACA	ICGC	PPTY	ITCH	1926:1929	Mutation altering degron motif	0.834
p.A2010V	DO11429	GBM	ICGC	VRTPLSQVN	DEG_APCC_DBOX_1	2011:2019	Mutation rewiring degron network	0.3056
p.A2010V	AN3-CA	endometrium	COSMIC	VRTPLSQVN	DEG_APCC_DBOX_1	2011:2019	Mutation rewiring degron network	0.3056
p.R1924Q	DO219069	HNSC	ICGC	PPTY	ITCH	1926:1929	Mutation rewiring degron network	0.2778
p.R1924Q	ACH-000995	Leukemia	CCLE	PPTY	ITCH	1926:1929	Mutation rewiring degron network	0.2778
p.H1932N	DO229031	LICA	ICGC	PPTY	ITCH	1926:1929	Mutation rewiring degron network	0.25
p.T1928K	DO44832	LICA	ICGC	PPTY	ITCH	1926:1929	Mutation altering degron motif	0.6195
p.R1918L	DO231152	LUSC	ICGC	PPTY	ITCH	1926:1929	Mutation rewiring degron network	0.1111
p.R1918C	DO220878	MELA	ICGC	PPTY	ITCH	1926:1929	Mutation rewiring degron network	0.1111
p.R1918C	DO37406	SKCM	ICGC	PPTY	ITCH	1926:1929	Mutation rewiring degron network	0.1111
p.T1928M	DO38567	STAD	ICGC	PPTY	ITCH	1926:1929	Mutation altering degron motif	0.6312
p.Q2017R	DO229272	THCA	ICGC	VRTPLSQVN	DEG_APCC_DBOX_1	2011:2019	Mutation altering degron motif	0.6218
p.R1936H	DO40978	UCEC	ICGC	PPTY	ITCH	1926:1929	Mutation rewiring degron network	0.1389
p.R1918H	DO42608	UCEC	ICGC	PPTY	ITCH	1926:1929	Mutation rewiring degron network	0.1111
p.P2024L	SIDM00080	Melanoma	GDSC	VRTPLSQVN	DEG_APCC_DBOX_1	2011:2019	Mutation rewiring degron network	0.1944
p.P2024L	SK-MEL-5	skin	COSMIC	VRTPLSQVN	DEG_APCC_DBOX_1	2011:2019	Mutation rewiring degron network	0.1944
p.P2024S	SIDM00080	Melanoma	GDSC	VRTPLSQVN	DEG_APCC_DBOX_1	2011:2019	Mutation rewiring degron network	0.1944
p.P2024S	ACH-000730	Skin Cancer	CCLE	VRTPLSQVN	DEG_APCC_DBOX_1	2011:2019	Mutation rewiring degron network	0.1944
p.P2024S	SK-MEL-5	skin	COSMIC	VRTPLSQVN	DEG_APCC_DBOX_1	2011:2019	Mutation rewiring degron network	0.1944
p.R2010S	ACH-000817	Myeloma	CCLE	VRTPLSQVN	DEG_APCC_DBOX_1	2011:2019	Mutation rewiring degron network	0.3056
p.R2010S	RPMI-8226	haematopoietic and lymphoid tissue	COSMIC	VRTPLSQVN	DEG_APCC_DBOX_1	2011:2019	Mutation rewiring degron network	0.3056
p.V2011M	CAL-33	upper aerodigestive tract	COSMIC	VRTPLSQVN	DEG_APCC_DBOX_1	2011:2019	Mutation altering degron motif	0.6097

Kaplan plot for CIT in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CIT

UniProt ID: O14578

Entrez ID: 11113

Protein name: Citron Rho-interacting kinase (CRIK) (EC 2.7.11.1) (Serine/threonine-protein kinase 21)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CIT in