DegronMD

Uniprot ID: O14578

Source protein: Citron Rho-interacting kinase

Source gene: CIT

Class: DEG_APCC_DBOX_1

Location: 2011:2019

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9582

ASA_SCORE: 77.0111

COIL: 0.6691

CONS_SCORE: 0.1671

DSS_SCORE: 0.4689

HELIX: 0.1769

FCONS_SCORE: 0.8452

RIG_SCORE: 0.7358

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R2002L	TCGA-56-7823	LUSC	TCGA	VRTPLSQVN	DEG_APCC_DBOX_1	0.5278
p.R2009L	TCGA-78-7149	LUAD	TCGA	VRTPLSQVN	DEG_APCC_DBOX_1	0.2778
p.R2016H	TCGA-86-8055	LUAD	TCGA	VRTPLSQVN	DEG_APCC_DBOX_1	0.8244
p.R2016C	TCGA-AJ-A3BH	UCEC	TCGA	VRTPLSQVN	DEG_APCC_DBOX_1	0.8301
p.R2016C	ACH-000961	Endometrial/Uterine Cancer	CCLE	VRTPLSQVN	DEG_APCC_DBOX_1	0.8301
p.L2008V	TCGA-CG-4437	STAD	TCGA	VRTPLSQVN	DEG_APCC_DBOX_1	0.25
p.R2009C	TCGA-EO-A22U	UCEC	TCGA	VRTPLSQVN	DEG_APCC_DBOX_1	0.2778
p.R2009C	ACH-000971	Colon/Colorectal Cancer	CCLE	VRTPLSQVN	DEG_APCC_DBOX_1	0.2778
p.R2002H	TCGA-EY-A549	UCEC	TCGA	VRTPLSQVN	DEG_APCC_DBOX_1	0.5278
p.A2008T	DO227987	COCA	ICGC	VRTPLSQVN	DEG_APCC_DBOX_1	0.25
p.A2010V	DO11429	GBM	ICGC	VRTPLSQVN	DEG_APCC_DBOX_1	0.3056
p.A2010V	AN3-CA	endometrium	COSMIC	VRTPLSQVN	DEG_APCC_DBOX_1	0.3056
p.Q2017R	DO229272	THCA	ICGC	VRTPLSQVN	DEG_APCC_DBOX_1	0.6218
p.P2024L	SIDM00080	Melanoma	GDSC	VRTPLSQVN	DEG_APCC_DBOX_1	0.1944
p.P2024L	SK-MEL-5	skin	COSMIC	VRTPLSQVN	DEG_APCC_DBOX_1	0.1944
p.P2024S	SIDM00080	Melanoma	GDSC	VRTPLSQVN	DEG_APCC_DBOX_1	0.1944
p.P2024S	ACH-000730	Skin Cancer	CCLE	VRTPLSQVN	DEG_APCC_DBOX_1	0.1944
p.P2024S	SK-MEL-5	skin	COSMIC	VRTPLSQVN	DEG_APCC_DBOX_1	0.1944
p.R2010S	ACH-000817	Myeloma	CCLE	VRTPLSQVN	DEG_APCC_DBOX_1	0.3056
p.R2010S	RPMI-8226	haematopoietic_and_lymphoid_tissue	COSMIC	VRTPLSQVN	DEG_APCC_DBOX_1	0.3056
p.V2011M	CAL-33	upper_aerodigestive_tract	COSMIC	VRTPLSQVN	DEG_APCC_DBOX_1	0.6097

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14578	Citron Rho-interacting kinase	DEG_APCC_DBOX_1	2011:2019	VRTPLSQVN	APC,CDC20,FZR1	0.9582	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons