DegronMD

Uniprot ID: O14578

Source protein: Citron Rho-interacting kinase

Source gene: CIT

Class: DEG_SPOP_SBC_1

Location: 442:446

E3 ligase: SPOP

DEGRON score: 0.8991

ASA_SCORE: 59.66

COIL: 0.5754

CONS_SCORE: 0.3264

DSS_SCORE: 0.4159

HELIX: 0.344

FCONS_SCORE: 0.9909

RIG_SCORE: 0.6886

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K454E	TCGA-4Z-AA7O	BLCA	TCGA	AKTSS	DEG_SPOP_SBC_1	0.2222
p.K454E	DO51865	BLCA	ICGC	AKTSS	DEG_SPOP_SBC_1	0.2222
p.S445C	TCGA-85-7699	LUSC	TCGA	AKTSS	DEG_SPOP_SBC_1	0.7541
p.S445C	DO26534	LUSC	ICGC	AKTSS	DEG_SPOP_SBC_1	0.7541
p.P441H	TCGA-BW-A5NO	LIHC	TCGA	AKTSS	DEG_SPOP_SBC_1	0.3056
p.P441H	DO52171	LIHC	ICGC	AKTSS	DEG_SPOP_SBC_1	0.3056
p.V434A	TCGA-CV-A460	HNSC	TCGA	AKTSS	DEG_SPOP_SBC_1	0.1111
p.V434A	DO52065	HNSC	ICGC	AKTSS	DEG_SPOP_SBC_1	0.1111
p.S446F	TCGA-EE-A2GD	SKCM	TCGA	AKTSS	DEG_SPOP_SBC_1	0.7982
p.S446F	DO37603	SKCM	ICGC	AKTSS	DEG_SPOP_SBC_1	0.7982
p.K450T	DO222884	COCA	ICGC	AKTSS	DEG_SPOP_SBC_1	0.3333

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14578	Citron Rho-interacting kinase	DEG_SPOP_SBC_1	442:446	AKTSS	SPOP	0.8991	More...
P28324	ETS domain-containing protein Elk-4	DEG_SPOP_SBC_1	133:137	AKTSS	SPOP	0.947	More...
P49023	Paxillin	DEG_SPOP_SBC_1	92:96	AKTSS	SPOP	0.9674	More...
Q6PIL6	Kv channel-interacting protein 4	DEG_SPOP_SBC_1	46:50	AKTSS	SPOP	0.5322	More...
Q96CB8	Integrator complex subunit 12	DEG_SPOP_SBC_1	298:302	AKTSS	SPOP	0.6377	More...
Q9UKK3	Protein mono-ADP-ribosyltransferase PARP4	DEG_SPOP_SBC_1	603:607	AKTSS	SPOP	0.5644	More...
Q9ULD9	Zinc finger protein 608	DEG_SPOP_SBC_1	932:936	AKTSS	SPOP	0.9688	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons