DegronMD - Q96CB8(INTS12)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S324L	TCGA-06-5416	GBM	TCGA	PATSS	DEG_SPOP_SBC_1	321:325	Mutation altering degron motif	0.7667
p.S324L	DO10880	GBM	ICGC	PATSS	DEG_SPOP_SBC_1	321:325	Mutation altering degron motif	0.7667
p.S324L	DO222753	MELA	ICGC	PATSS	DEG_SPOP_SBC_1	321:325	Mutation altering degron motif	0.7667
p.V331M	TCGA-28-2502	GBM	TCGA	PATSS	DEG_SPOP_SBC_1	321:325	Mutation rewiring degron network	0.1667
p.V331M	DO13983	GBM	ICGC	PATSS	DEG_SPOP_SBC_1	321:325	Mutation rewiring degron network	0.1667
p.P305H	TCGA-63-7021	LUSC	TCGA	AKTSS	DEG_SPOP_SBC_1	298:302	Mutation rewiring degron network	0.25
p.P305H	DO26782	LUSC	ICGC	AKTSS	DEG_SPOP_SBC_1	298:302	Mutation rewiring degron network	0.25
p.T334A	TCGA-AU-6004	COAD	TCGA	PATSS	DEG_SPOP_SBC_1	321:325	Mutation rewiring degron network	0.0833
p.T334A	DO7780	COAD	ICGC	PATSS	DEG_SPOP_SBC_1	321:325	Mutation rewiring degron network	0.0833
p.P390S	TCGA-D8-A27G	BRCA	TCGA	PGSSS	DEG_SPOP_SBC_1	395:399	Mutation rewiring degron network	0.1944
p.P390S	DO5465	BRCA	ICGC	PGSSS	DEG_SPOP_SBC_1	395:399	Mutation rewiring degron network	0.1944
p.L310W	TCGA-E6-A1LX	UCEC	TCGA	AKTSS	DEG_SPOP_SBC_1	298:302	Mutation rewiring degron network	0.1111
p.L310W	DO41020	UCEC	ICGC	AKTSS	DEG_SPOP_SBC_1	298:302	Mutation rewiring degron network	0.1111
p.T307K	DO229031	LICA	ICGC	AKTSS	DEG_SPOP_SBC_1	298:302	Mutation rewiring degron network	0.1944
p.T334N	DO229045	LICA	ICGC	PATSS	DEG_SPOP_SBC_1	321:325	Mutation rewiring degron network	0.0833
p.N317S	DO48719	LIRI	ICGC	PATSS	DEG_SPOP_SBC_1	321:325	Mutation rewiring degron network	0.2222
p.Q328H	DO228346	MALY	ICGC	PATSS	DEG_SPOP_SBC_1	321:325	Mutation rewiring degron network	0.25
p.N316T	DO221125	MALY	ICGC	PATSS	DEG_SPOP_SBC_1	321:325	Mutation rewiring degron network	0.1944
p.K309N	SIDM00654	Small Cell Lung Carcinoma	GDSC	AKTSS	DEG_SPOP_SBC_1	298:302	Mutation substituting flanking lysine	0.25
p.K309N	ACH-000866	Lung Cancer	CCLE	AKTSS	DEG_SPOP_SBC_1	298:302	Mutation substituting flanking lysine	0.25
p.K309N	NCI-H1048	lung	COSMIC	AKTSS	DEG_SPOP_SBC_1	298:302	Mutation substituting flanking lysine	0.25
p.L310S	SIDM00592	Oral Cavity Carcinoma	GDSC	AKTSS	DEG_SPOP_SBC_1	298:302	Mutation rewiring degron network	0.1111
p.L310S	SIDM01194	Hepatocellular Carcinoma	GDSC	AKTSS	DEG_SPOP_SBC_1	298:302	Mutation rewiring degron network	0.1111
p.L310S	SIDM00349	Esophageal Squamous Cell Carcinoma	GDSC	AKTSS	DEG_SPOP_SBC_1	298:302	Mutation rewiring degron network	0.1111
p.L310S	SIDM01372	Pancreatic Carcinoma	GDSC	AKTSS	DEG_SPOP_SBC_1	298:302	Mutation rewiring degron network	0.1111
p.L310S	SNU-449	liver	COSMIC	AKTSS	DEG_SPOP_SBC_1	298:302	Mutation rewiring degron network	0.1111
p.L310S	TE-10	oesophagus	COSMIC	AKTSS	DEG_SPOP_SBC_1	298:302	Mutation rewiring degron network	0.1111
p.L310S	HO-1-N-1	salivary gland	COSMIC	AKTSS	DEG_SPOP_SBC_1	298:302	Mutation rewiring degron network	0.1111

Kaplan plot for INTS12 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

INTS12

UniProt ID: Q96CB8

Entrez ID: 57117

Protein name: Integrator complex subunit 12 (Int12) (PHD finger protein 22)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for INTS12 in