DegronMD

Uniprot ID: Q96CB8

Source protein: Integrator complex subunit 12

Source gene: INTS12

Class: DEG_SPOP_SBC_1

Location: 298:302

E3 ligase: SPOP

DEGRON score: 0.6377

ASA_SCORE: 84.66

COIL: 0.8186

CONS_SCORE: 0.3553

DSS_SCORE: 0.3627

HELIX: 0.151

FCONS_SCORE: 0.9464

RIG_SCORE: 0.7031

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P305H	TCGA-63-7021	LUSC	TCGA	AKTSS	DEG_SPOP_SBC_1	0.25
p.P305H	DO26782	LUSC	ICGC	AKTSS	DEG_SPOP_SBC_1	0.25
p.L310W	TCGA-E6-A1LX	UCEC	TCGA	AKTSS	DEG_SPOP_SBC_1	0.1111
p.L310W	DO41020	UCEC	ICGC	AKTSS	DEG_SPOP_SBC_1	0.1111
p.T307K	DO229031	LICA	ICGC	AKTSS	DEG_SPOP_SBC_1	0.1944
p.K309N	SIDM00654	Small Cell Lung Carcinoma	GDSC	AKTSS	DEG_SPOP_SBC_1	0.25
p.K309N	ACH-000866	Lung Cancer	CCLE	AKTSS	DEG_SPOP_SBC_1	0.25
p.K309N	NCI-H1048	lung	COSMIC	AKTSS	DEG_SPOP_SBC_1	0.25
p.L310S	SIDM00592	Oral Cavity Carcinoma	GDSC	AKTSS	DEG_SPOP_SBC_1	0.1111
p.L310S	SIDM01194	Hepatocellular Carcinoma	GDSC	AKTSS	DEG_SPOP_SBC_1	0.1111
p.L310S	SIDM00349	Esophageal Squamous Cell Carcinoma	GDSC	AKTSS	DEG_SPOP_SBC_1	0.1111
p.L310S	SIDM01372	Pancreatic Carcinoma	GDSC	AKTSS	DEG_SPOP_SBC_1	0.1111
p.L310S	SNU-449	liver	COSMIC	AKTSS	DEG_SPOP_SBC_1	0.1111
p.L310S	TE-10	oesophagus	COSMIC	AKTSS	DEG_SPOP_SBC_1	0.1111
p.L310S	HO-1-N-1	salivary_gland	COSMIC	AKTSS	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14578	Citron Rho-interacting kinase	DEG_SPOP_SBC_1	442:446	AKTSS	SPOP	0.8991	More...
P28324	ETS domain-containing protein Elk-4	DEG_SPOP_SBC_1	133:137	AKTSS	SPOP	0.947	More...
P49023	Paxillin	DEG_SPOP_SBC_1	92:96	AKTSS	SPOP	0.9674	More...
Q6PIL6	Kv channel-interacting protein 4	DEG_SPOP_SBC_1	46:50	AKTSS	SPOP	0.5322	More...
Q96CB8	Integrator complex subunit 12	DEG_SPOP_SBC_1	298:302	AKTSS	SPOP	0.6377	More...
Q9UKK3	Protein mono-ADP-ribosyltransferase PARP4	DEG_SPOP_SBC_1	603:607	AKTSS	SPOP	0.5644	More...
Q9ULD9	Zinc finger protein 608	DEG_SPOP_SBC_1	932:936	AKTSS	SPOP	0.9688	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons