DegronMD

Uniprot ID: Q6PIL6

Source protein: Kv channel-interacting protein 4

Source gene: KCNIP4

Class: DEG_SPOP_SBC_1

Location: 46:50

E3 ligase: SPOP

DEGRON score: 0.5322

ASA_SCORE: 86.22

COIL: 0.883

CONS_SCORE: 0.2306

DSS_SCORE: 0.4011

HELIX: 0.0666

FCONS_SCORE: 0.6384

RIG_SCORE: 0.6607

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A46T	TCGA-AJ-A2QK	UCEC	TCGA	AKTSS	DEG_SPOP_SBC_1	0.7139
p.A46T	DO41301	UCEC	ICGC	AKTSS	DEG_SPOP_SBC_1	0.7139
p.M38I	TCGA-BA-5152	HNSC	TCGA	AKTSS	DEG_SPOP_SBC_1	0.1111
p.M38I	DO14393	HNSC	ICGC	AKTSS	DEG_SPOP_SBC_1	0.1111
p.D59N	TCGA-D3-A1QB	SKCM	TCGA	AKTSS	DEG_SPOP_SBC_1	0.0833
p.D59N	DO47573	SKCM	ICGC	AKTSS	DEG_SPOP_SBC_1	0.0833
p.E60K	TCGA-FR-A8YC	SKCM	TCGA	AKTSS	DEG_SPOP_SBC_1	0.0556
p.E60K	DO50301	SKCM	ICGC	AKTSS	DEG_SPOP_SBC_1	0.0556
p.P51S	TCGA-FW-A3R5	SKCM	TCGA	AKTSS	DEG_SPOP_SBC_1	0.3056
p.P51S	DO37406	SKCM	ICGC	AKTSS	DEG_SPOP_SBC_1	0.3056
p.T48M	DO234459	ESAD	ICGC	AKTSS	DEG_SPOP_SBC_1	0.7423
p.T48M	DO34696	PACA	ICGC	AKTSS	DEG_SPOP_SBC_1	0.7423
p.S50Y	DO52667	MALY	ICGC	AKTSS	DEG_SPOP_SBC_1	0.712
p.P42S	DO219873	SKCA	ICGC	AKTSS	DEG_SPOP_SBC_1	0.2222
p.L37I	SIDM00227	Neuroblastoma	GDSC	AKTSS	DEG_SPOP_SBC_1	0.0833
p.L37I	ACH-001344	Neuroblastoma	CCLE	AKTSS	DEG_SPOP_SBC_1	0.0833
p.L37I	GI-ME-N	autonomic_ganglia	COSMIC	AKTSS	DEG_SPOP_SBC_1	0.0833
p.K39R	SIDM00946	T-Lymphoblastic Leukemia	GDSC	AKTSS	DEG_SPOP_SBC_1	0.25
p.K39R	ACH-000981	Leukemia	CCLE	AKTSS	DEG_SPOP_SBC_1	0.25
p.K39R	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	AKTSS	DEG_SPOP_SBC_1	0.25
p.S49L	SIDM01588	Endometrial Carcinoma	GDSC	AKTSS	DEG_SPOP_SBC_1	0.7667
p.S59R	ACH-000489	Colon/Colorectal Cancer	CCLE	AKTSS	DEG_SPOP_SBC_1	0.0833
p.S59R	SW1116	large_intestine	COSMIC	AKTSS	DEG_SPOP_SBC_1	0.0833
p.S59G	ACH-000956	Prostate Cancer	CCLE	AKTSS	DEG_SPOP_SBC_1	0.0833
p.S59G	22RV1	prostate	COSMIC	AKTSS	DEG_SPOP_SBC_1	0.0833
p.L52F	ACH-000968	Skin Cancer	CCLE	AKTSS	DEG_SPOP_SBC_1	0.2778
p.L52F	COLO-792	skin	COSMIC	AKTSS	DEG_SPOP_SBC_1	0.2778
p.A43V	ACH-000991	Colon/Colorectal Cancer	CCLE	AKTSS	DEG_SPOP_SBC_1	0.25
p.A43V	SNU-81	large_intestine	COSMIC	AKTSS	DEG_SPOP_SBC_1	0.25
p.V45I	ACH-001024	Skin Cancer	CCLE	AKTSS	DEG_SPOP_SBC_1	0.3056
p.V45I	ACH-001786	Colon/Colorectal Cancer	CCLE	AKTSS	DEG_SPOP_SBC_1	0.3056
p.V45I	CHL-1	skin	COSMIC	AKTSS	DEG_SPOP_SBC_1	0.3056
p.A39V	SNU-81	large_intestine	COSMIC	AKTSS	DEG_SPOP_SBC_1	0.25
p.T60A	P30-OHK	haematopoietic_and_lymphoid_tissue	COSMIC	AKTSS	DEG_SPOP_SBC_1	0.0556
p.S55R	SW1116	large_intestine	COSMIC	AKTSS	DEG_SPOP_SBC_1	0.1944
p.L56F	COLO-792	skin	COSMIC	AKTSS	DEG_SPOP_SBC_1	0.1667
p.V41I	CHL-1	skin	COSMIC	AKTSS	DEG_SPOP_SBC_1	0.1944
p.S55G	22RV1	prostate	COSMIC	AKTSS	DEG_SPOP_SBC_1	0.1944
p.T58S	SBC-5	lung	COSMIC	AKTSS	DEG_SPOP_SBC_1	0.1111
p.L39F	COLO-792	skin	COSMIC	AKTSS	DEG_SPOP_SBC_1	0.25
p.A47V	SNU-81	large_intestine	COSMIC	AKTSS	DEG_SPOP_SBC_1	0.6936
p.V49I	CHL-1	skin	COSMIC	AKTSS	DEG_SPOP_SBC_1	0.7076
p.T49S	SBC-5	lung	COSMIC	AKTSS	DEG_SPOP_SBC_1	0.7116
p.S46G	22RV1	prostate	COSMIC	AKTSS	DEG_SPOP_SBC_1	0.6993
p.S46R	SW1116	large_intestine	COSMIC	AKTSS	DEG_SPOP_SBC_1	0.7427
p.L48F	COLO-792	skin	COSMIC	AKTSS	DEG_SPOP_SBC_1	0.6981

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14578	Citron Rho-interacting kinase	DEG_SPOP_SBC_1	442:446	AKTSS	SPOP	0.8991	More...
P28324	ETS domain-containing protein Elk-4	DEG_SPOP_SBC_1	133:137	AKTSS	SPOP	0.947	More...
P49023	Paxillin	DEG_SPOP_SBC_1	92:96	AKTSS	SPOP	0.9674	More...
Q6PIL6	Kv channel-interacting protein 4	DEG_SPOP_SBC_1	46:50	AKTSS	SPOP	0.5322	More...
Q96CB8	Integrator complex subunit 12	DEG_SPOP_SBC_1	298:302	AKTSS	SPOP	0.6377	More...
Q9UKK3	Protein mono-ADP-ribosyltransferase PARP4	DEG_SPOP_SBC_1	603:607	AKTSS	SPOP	0.5644	More...
Q9ULD9	Zinc finger protein 608	DEG_SPOP_SBC_1	932:936	AKTSS	SPOP	0.9688	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AKTSS

Degron related mutations and impact score

Drug responses associated with KCNIP4 mutations

All proteins holding degron of AKTSS