DegronMD - P49023(PXN)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S227F	TCGA-06-5416	GBM	TCGA	DELESSVPSP	DEG_COP1_1	222:231	Mutation altering degron motif	0.6871
p.S227F	TCGA-XF-A9T0	BLCA	TCGA	DELESSVPSP	DEG_COP1_1	222:231	Mutation altering degron motif	0.6871
p.E241D	TCGA-24-2289	OV	TCGA	DELESSVPSP	DEG_COP1_1	222:231	Mutation rewiring degron network	0.0556
p.M134I	TCGA-33-6737	LUSC	TCGA	VMSTS	DEG_SPOP_SBC_1	133:137	Mutation altering degron motif	0.6507
p.M134I	TCGA-AJ-A3EL	UCEC	TCGA	VMSTS	DEG_SPOP_SBC_1	133:137	Mutation altering degron motif	0.6507
p.E128K	TCGA-AJ-A3TW	UCEC	TCGA	VMSTS	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.1944
p.R147H	TCGA-AP-A051	UCEC	TCGA	VMSTS	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.0556
p.R147H	SIDM00217	Colorectal Carcinoma	GDSC	VMSTS	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.0556
p.R147H	SNU-1040	large intestine	COSMIC	VMSTS	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.0556
p.L138M	TCGA-BR-8361	STAD	TCGA	VMSTS	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.3056
p.Q124H	TCGA-CN-6010	HNSC	TCGA	VMSTS	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.0833
p.Q124H	TCGA-ND-A4WA	UCS	TCGA	VMSTS	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.0833
p.V237A	TCGA-FI-A2D5	UCEC	TCGA	DELESSVPSP	DEG_COP1_1	222:231	Mutation rewiring degron network	0.1667
p.S94F	DO51920	BLCA	ICGC	AKTSS	DEG_SPOP_SBC_1	92:96	Mutation altering degron motif	0.7982
p.S94F	DO10880	GBM	ICGC	AKTSS	DEG_SPOP_SBC_1	92:96	Mutation altering degron motif	0.7982
p.L218V	DO225354	BRCA	ICGC	DELESSVPSP	DEG_COP1_1	222:231	Mutation rewiring degron network	0.2222
p.H214Q	DO219745	CESC	ICGC	DELESSVPSP	DEG_COP1_1	222:231	Mutation rewiring degron network	0.1111
p.V216A	DO51734	COAD	ICGC	DELESSVPSP	DEG_COP1_1	222:231	Mutation rewiring degron network	0.1667
p.S77P	DO8447	COAD	ICGC	PQSSS	DEG_SPOP_SBC_1	81:85	Mutation rewiring degron network	0.2222
p.S71G	DO229010	COCA	ICGC	PQSSS	DEG_SPOP_SBC_1	81:85	Mutation rewiring degron network	0.0556
p.S71G	DO229013	COCA	ICGC	PQSSS	DEG_SPOP_SBC_1	81:85	Mutation rewiring degron network	0.0556
p.S71G	DO229016	COCA	ICGC	PQSSS	DEG_SPOP_SBC_1	81:85	Mutation rewiring degron network	0.0556
p.S71G	DO229003	COCA	ICGC	PQSSS	DEG_SPOP_SBC_1	81:85	Mutation rewiring degron network	0.0556
p.S71G	DO229005	COCA	ICGC	PQSSS	DEG_SPOP_SBC_1	81:85	Mutation rewiring degron network	0.0556
p.D134E	DO229035	LICA	ICGC	VMSTS	DEG_SPOP_SBC_1	133:137	Mutation altering degron motif	0.6758
p.Q99K	DO229037	LICA	ICGC	AKTSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.25
p.L146M	DO27025	LUSC	ICGC	VMSTS	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.0833
p.G225E	DO222727	MELA	ICGC	DELESSVPSP	DEG_COP1_1	222:231	Mutation altering degron motif	0.7199
p.G225E	DO38028	SKCM	ICGC	DELESSVPSP	DEG_COP1_1	222:231	Mutation altering degron motif	0.7199
p.E239D	DO30210	OV	ICGC	DELESSVPSP	DEG_COP1_1	222:231	Mutation rewiring degron network	0.1111
p.K240E	DO29940	OV	ICGC	DELESSVPSP	DEG_COP1_1	222:231	Mutation rewiring degron network	0.0833
p.F230L	DO28373	OV	ICGC	DELESSVPSP	DEG_COP1_1	222:231	Mutation altering degron motif	0.6981
p.R212W	DO232761	PBCA	ICGC	DELESSVPSP	DEG_COP1_1	222:231	Mutation rewiring degron network	0.0556
p.P105Q	DO37766	SKCM	ICGC	AKTSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.0833
p.S226T	DO38123	SKCM	ICGC	DELESSVPSP	DEG_COP1_1	222:231	Mutation altering degron motif	0.6005
p.L136M	DO48032	STAD	ICGC	VMSTS	DEG_SPOP_SBC_1	133:137	Mutation altering degron motif	0.711
p.M132I	DO41542	UCEC	ICGC	VMSTS	DEG_SPOP_SBC_1	133:137	Mutation blocking phosphorylation signal	0.75
p.L86F	DO41999	UCEC	ICGC	PQSSS	DEG_SPOP_SBC_1	81:85	Mutation rewiring degron network	0.3056
p.L86F	DO41999	UCEC	ICGC	AKTSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.1667
p.E126K	DO43723	UCEC	ICGC	VMSTS	DEG_SPOP_SBC_1	133:137	Mutation blocking phosphorylation signal	0.5833
p.V235A	DO41331	UCEC	ICGC	DELESSVPSP	DEG_COP1_1	222:231	Mutation rewiring degron network	0.2222
p.S83F	SIDM01307	Colorectal Carcinoma	GDSC	PQSSS	DEG_SPOP_SBC_1	81:85	Mutation altering degron motif	0.9093
p.G240C	SIDM00946	T-Lymphoblastic Leukemia	GDSC	DELESSVPSP	DEG_COP1_1	222:231	Mutation rewiring degron network	0.0833
p.V232I	SIDM00962	Chronic Myelogenous Leukemia	GDSC	DELESSVPSP	DEG_COP1_1	222:231	Mutation rewiring degron network	0.3056
p.V87E	SIDM00573	Glioblastoma	GDSC	PQSSS	DEG_SPOP_SBC_1	81:85	Mutation rewiring degron network	0.2778
p.V87E	SIDM00573	Glioblastoma	GDSC	AKTSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.1944
p.V87E	no-11	central nervous system	COSMIC	PQSSS	DEG_SPOP_SBC_1	81:85	Mutation rewiring degron network	0.2778
p.V87E	no-11	central nervous system	COSMIC	AKTSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.1944
p.E241K	SIDM00997	Thyroid Gland Carcinoma	GDSC	DELESSVPSP	DEG_COP1_1	222:231	Mutation rewiring degron network	0.0556
p.E241K	ACH-000862	Bladder Cancer	CCLE	DELESSVPSP	DEG_COP1_1	222:231	Mutation rewiring degron network	0.0556
p.E241K	ACH-001306	Thyroid Cancer	CCLE	DELESSVPSP	DEG_COP1_1	222:231	Mutation rewiring degron network	0.0556
p.P129L	SIDM01083	Oral Cavity Carcinoma	GDSC	VMSTS	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.2222
p.P129L	SIDM00603	Head and Neck Carcinoma	GDSC	VMSTS	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.2222
p.R214Q	SIDM00150	Colorectal Carcinoma	GDSC	DELESSVPSP	DEG_COP1_1	222:231	Mutation rewiring degron network	0.1111
p.R214Q	KM12	large intestine	COSMIC	DELESSVPSP	DEG_COP1_1	222:231	Mutation rewiring degron network	0.1111
p.P231L	ACH-000690	Lung Cancer	CCLE	DELESSVPSP	DEG_COP1_1	222:231	Mutation altering degron motif	0.6471
p.V237M	ACH-000954	Endometrial/Uterine Cancer	CCLE	DELESSVPSP	DEG_COP1_1	222:231	Mutation rewiring degron network	0.1667
p.R212Q	ACH-000969	Colon/Colorectal Cancer	CCLE	DELESSVPSP	DEG_COP1_1	222:231	Mutation rewiring degron network	0.0556
p.R212Q	KM12	large intestine	COSMIC	DELESSVPSP	DEG_COP1_1	222:231	Mutation rewiring degron network	0.0556
p.P105L	KMOE-2	haematopoietic and lymphoid tissue	COSMIC	AKTSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.0833
p.R81Q	KM12	large intestine	COSMIC	PQSSS	DEG_SPOP_SBC_1	81:85	Mutation altering degron motif	0.7329
p.F229L	EN	endometrium	COSMIC	DELESSVPSP	DEG_COP1_1	222:231	Mutation altering degron motif	0.6981
p.R145H	SNU-1040	large intestine	COSMIC	VMSTS	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.1111
p.V85E	no-11	central nervous system	COSMIC	PQSSS	DEG_SPOP_SBC_1	81:85	Mutation altering degron motif	0.7693

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PXN

UniProt ID: P49023

Entrez ID: 5829

Protein name: Paxillin

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PXN in