DegronMD

Uniprot ID: P49023

Source protein: Paxillin

Source gene: PXN

Class: DEG_SPOP_SBC_1

Location: 133:137

E3 ligase: SPOP

DEGRON score: 0.9941

ASA_SCORE: 86.42

COIL: 0.8986

CONS_SCORE: 0.5121

DSS_SCORE: 0.5692

HELIX: 0.0406

FCONS_SCORE: 1.2031

RIG_SCORE: 0.6946

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M134I	TCGA-33-6737	LUSC	TCGA	VMSTS	DEG_SPOP_SBC_1	0.6507
p.M134I	TCGA-AJ-A3EL	UCEC	TCGA	VMSTS	DEG_SPOP_SBC_1	0.6507
p.E128K	TCGA-AJ-A3TW	UCEC	TCGA	VMSTS	DEG_SPOP_SBC_1	0.1944
p.R147H	TCGA-AP-A051	UCEC	TCGA	VMSTS	DEG_SPOP_SBC_1	0.0556
p.R147H	SIDM00217	Colorectal Carcinoma	GDSC	VMSTS	DEG_SPOP_SBC_1	0.0556
p.R147H	SNU-1040	large_intestine	COSMIC	VMSTS	DEG_SPOP_SBC_1	0.0556
p.L138M	TCGA-BR-8361	STAD	TCGA	VMSTS	DEG_SPOP_SBC_1	0.3056
p.Q124H	TCGA-CN-6010	HNSC	TCGA	VMSTS	DEG_SPOP_SBC_1	0.0833
p.Q124H	TCGA-ND-A4WA	UCS	TCGA	VMSTS	DEG_SPOP_SBC_1	0.0833
p.D134E	DO229035	LICA	ICGC	VMSTS	DEG_SPOP_SBC_1	0.6758
p.L146M	DO27025	LUSC	ICGC	VMSTS	DEG_SPOP_SBC_1	0.0833
p.L136M	DO48032	STAD	ICGC	VMSTS	DEG_SPOP_SBC_1	0.711
p.M132I	DO41542	UCEC	ICGC	VMSTS	DEG_SPOP_SBC_1	0.75
p.E126K	DO43723	UCEC	ICGC	VMSTS	DEG_SPOP_SBC_1	0.5833
p.P129L	SIDM01083	Oral Cavity Carcinoma	GDSC	VMSTS	DEG_SPOP_SBC_1	0.2222
p.P129L	SIDM00603	Head and Neck Carcinoma	GDSC	VMSTS	DEG_SPOP_SBC_1	0.2222
p.R145H	SNU-1040	large_intestine	COSMIC	VMSTS	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P49023	Paxillin	DEG_SPOP_SBC_1	133:137	VMSTS	SPOP	0.9941	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons