DegronMD

Uniprot ID: P49023

Source protein: Paxillin

Source gene: PXN

Class: DEG_SPOP_SBC_1

Location: 92:96

E3 ligase: SPOP

DEGRON score: 0.9674

ASA_SCORE: 93.72

COIL: 0.926

CONS_SCORE: 0.1923

DSS_SCORE: 0.6218

HELIX: 0.0212

FCONS_SCORE: 0.8132

RIG_SCORE: 0.5739

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S94F	DO51920	BLCA	ICGC	AKTSS	DEG_SPOP_SBC_1	0.7982
p.S94F	DO10880	GBM	ICGC	AKTSS	DEG_SPOP_SBC_1	0.7982
p.Q99K	DO229037	LICA	ICGC	AKTSS	DEG_SPOP_SBC_1	0.25
p.P105Q	DO37766	SKCM	ICGC	AKTSS	DEG_SPOP_SBC_1	0.0833
p.L86F	DO41999	UCEC	ICGC	AKTSS	DEG_SPOP_SBC_1	0.1667
p.V87E	SIDM00573	Glioblastoma	GDSC	AKTSS	DEG_SPOP_SBC_1	0.1944
p.V87E	no-11	central_nervous_system	COSMIC	AKTSS	DEG_SPOP_SBC_1	0.1944
p.P105L	KMOE-2	haematopoietic_and_lymphoid_tissue	COSMIC	AKTSS	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14578	Citron Rho-interacting kinase	DEG_SPOP_SBC_1	442:446	AKTSS	SPOP	0.8991	More...
P28324	ETS domain-containing protein Elk-4	DEG_SPOP_SBC_1	133:137	AKTSS	SPOP	0.947	More...
P49023	Paxillin	DEG_SPOP_SBC_1	92:96	AKTSS	SPOP	0.9674	More...
Q6PIL6	Kv channel-interacting protein 4	DEG_SPOP_SBC_1	46:50	AKTSS	SPOP	0.5322	More...
Q96CB8	Integrator complex subunit 12	DEG_SPOP_SBC_1	298:302	AKTSS	SPOP	0.6377	More...
Q9UKK3	Protein mono-ADP-ribosyltransferase PARP4	DEG_SPOP_SBC_1	603:607	AKTSS	SPOP	0.5644	More...
Q9ULD9	Zinc finger protein 608	DEG_SPOP_SBC_1	932:936	AKTSS	SPOP	0.9688	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons