DegronMD

Uniprot ID: Q9UKK3

Source protein: Protein mono-ADP-ribosyltransferase PARP4

Source gene: PARP4

Class: DEG_SPOP_SBC_1

Location: 603:607

E3 ligase: SPOP

DEGRON score: 0.5644

ASA_SCORE: 80.58

COIL: 0.83

CONS_SCORE: 0.2884

DSS_SCORE: 0.5219

HELIX: 0.115

FCONS_SCORE: 0.6837

RIG_SCORE: 0.6816

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D597H	TCGA-13-1488	OV	TCGA	AKTSS	DEG_SPOP_SBC_1	0.1667
p.D597H	DO29438	OV	ICGC	AKTSS	DEG_SPOP_SBC_1	0.1667
p.D597H	SIDM00445	Esophageal Carcinoma	GDSC	AKTSS	DEG_SPOP_SBC_1	0.1667
p.D597H	OACp4C	oesophagus	COSMIC	AKTSS	DEG_SPOP_SBC_1	0.1667
p.S593L	TCGA-49-AAR3	LUAD	TCGA	AKTSS	DEG_SPOP_SBC_1	0.0556
p.S593L	DO218919	LUAD	ICGC	AKTSS	DEG_SPOP_SBC_1	0.0556
p.D597E	TCGA-BR-6706	STAD	TCGA	AKTSS	DEG_SPOP_SBC_1	0.1667
p.D597E	DO38211	STAD	ICGC	AKTSS	DEG_SPOP_SBC_1	0.1667
p.D615N	TCGA-D8-A1JN	BRCA	TCGA	AKTSS	DEG_SPOP_SBC_1	0.1111
p.D615N	DO4311	BRCA	ICGC	AKTSS	DEG_SPOP_SBC_1	0.1111
p.S606F	TCGA-EE-A2MR	SKCM	TCGA	AKTSS	DEG_SPOP_SBC_1	0.7982
p.S606F	DO37819	SKCM	ICGC	AKTSS	DEG_SPOP_SBC_1	0.7982
p.Q599R	TCGA-J2-8194	LUAD	TCGA	AKTSS	DEG_SPOP_SBC_1	0.2222
p.Q599R	DO23971	LUAD	ICGC	AKTSS	DEG_SPOP_SBC_1	0.2222
p.P601Q	DO228952	LICA	ICGC	AKTSS	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14578	Citron Rho-interacting kinase	DEG_SPOP_SBC_1	442:446	AKTSS	SPOP	0.8991	More...
P28324	ETS domain-containing protein Elk-4	DEG_SPOP_SBC_1	133:137	AKTSS	SPOP	0.947	More...
P49023	Paxillin	DEG_SPOP_SBC_1	92:96	AKTSS	SPOP	0.9674	More...
Q6PIL6	Kv channel-interacting protein 4	DEG_SPOP_SBC_1	46:50	AKTSS	SPOP	0.5322	More...
Q96CB8	Integrator complex subunit 12	DEG_SPOP_SBC_1	298:302	AKTSS	SPOP	0.6377	More...
Q9UKK3	Protein mono-ADP-ribosyltransferase PARP4	DEG_SPOP_SBC_1	603:607	AKTSS	SPOP	0.5644	More...
Q9ULD9	Zinc finger protein 608	DEG_SPOP_SBC_1	932:936	AKTSS	SPOP	0.9688	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons