DegronMD

Uniprot ID: Q9ULD9

Source protein: Zinc finger protein 608

Source gene: ZNF608

Class: DEG_SPOP_SBC_1

Location: 932:936

E3 ligase: SPOP

DEGRON score: 0.9688

ASA_SCORE: 86.86

COIL: 0.917

CONS_SCORE: 0.4287

DSS_SCORE: 0.5649

HELIX: 0.044

FCONS_SCORE: 1.0497

RIG_SCORE: 0.6196

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P937L	TCGA-AP-A051	UCEC	TCGA	AKTSS	DEG_SPOP_SBC_1	0.3056
p.P937Q	TCGA-EE-A2GH	SKCM	TCGA	AKTSS	DEG_SPOP_SBC_1	0.3056
p.A946S	TCGA-EE-A2MS	SKCM	TCGA	AKTSS	DEG_SPOP_SBC_1	0.0556
p.A946S	SIDM00614	Hepatocellular Carcinoma	GDSC	AKTSS	DEG_SPOP_SBC_1	0.0556
p.A946S	ACH-000848	Liver Cancer	CCLE	AKTSS	DEG_SPOP_SBC_1	0.0556
p.A946S	JHH-7	liver	COSMIC	AKTSS	DEG_SPOP_SBC_1	0.0556
p.Q924K	TCGA-ER-A2NH	SKCM	TCGA	AKTSS	DEG_SPOP_SBC_1	0.1111
p.P923L	DO20815	KIRP	ICGC	AKTSS	DEG_SPOP_SBC_1	0.0833
p.V938A	DO47150	RECA	ICGC	AKTSS	DEG_SPOP_SBC_1	0.2778
p.R936W	DO43755	UCEC	ICGC	AKTSS	DEG_SPOP_SBC_1	0.8634
p.R936Q	DO42793	UCEC	ICGC	AKTSS	DEG_SPOP_SBC_1	0.7329

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14578	Citron Rho-interacting kinase	DEG_SPOP_SBC_1	442:446	AKTSS	SPOP	0.8991	More...
P28324	ETS domain-containing protein Elk-4	DEG_SPOP_SBC_1	133:137	AKTSS	SPOP	0.947	More...
P49023	Paxillin	DEG_SPOP_SBC_1	92:96	AKTSS	SPOP	0.9674	More...
Q6PIL6	Kv channel-interacting protein 4	DEG_SPOP_SBC_1	46:50	AKTSS	SPOP	0.5322	More...
Q96CB8	Integrator complex subunit 12	DEG_SPOP_SBC_1	298:302	AKTSS	SPOP	0.6377	More...
Q9UKK3	Protein mono-ADP-ribosyltransferase PARP4	DEG_SPOP_SBC_1	603:607	AKTSS	SPOP	0.5644	More...
Q9ULD9	Zinc finger protein 608	DEG_SPOP_SBC_1	932:936	AKTSS	SPOP	0.9688	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons