DegronMD - Q9UKK3(PARP4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D597H	TCGA-13-1488	OV	TCGA	AKTSS	DEG_SPOP_SBC_1	603:607	Mutation rewiring degron network	0.1667
p.D597H	DO29438	OV	ICGC	AKTSS	DEG_SPOP_SBC_1	603:607	Mutation rewiring degron network	0.1667
p.D597H	SIDM00445	Esophageal Carcinoma	GDSC	AKTSS	DEG_SPOP_SBC_1	603:607	Mutation rewiring degron network	0.1667
p.D597H	OACp4C	oesophagus	COSMIC	AKTSS	DEG_SPOP_SBC_1	603:607	Mutation rewiring degron network	0.1667
p.S593L	TCGA-49-AAR3	LUAD	TCGA	AKTSS	DEG_SPOP_SBC_1	603:607	Mutation rewiring degron network	0.0556
p.S593L	DO218919	LUAD	ICGC	AKTSS	DEG_SPOP_SBC_1	603:607	Mutation rewiring degron network	0.0556
p.G532A	TCGA-AC-A5XS	BRCA	TCGA	PPGY	ITCH	524:527	Mutation rewiring degron network	0.1944
p.G532A	DO50023	BRCA	ICGC	PPGY	ITCH	524:527	Mutation rewiring degron network	0.1944
p.D597E	TCGA-BR-6706	STAD	TCGA	AKTSS	DEG_SPOP_SBC_1	603:607	Mutation rewiring degron network	0.1667
p.D597E	DO38211	STAD	ICGC	AKTSS	DEG_SPOP_SBC_1	603:607	Mutation rewiring degron network	0.1667
p.D615N	TCGA-D8-A1JN	BRCA	TCGA	AKTSS	DEG_SPOP_SBC_1	603:607	Mutation rewiring degron network	0.1111
p.D615N	DO4311	BRCA	ICGC	AKTSS	DEG_SPOP_SBC_1	603:607	Mutation rewiring degron network	0.1111
p.S606F	TCGA-EE-A2MR	SKCM	TCGA	AKTSS	DEG_SPOP_SBC_1	603:607	Mutation altering degron motif	0.7982
p.S606F	DO37819	SKCM	ICGC	AKTSS	DEG_SPOP_SBC_1	603:607	Mutation altering degron motif	0.7982
p.Q599R	TCGA-J2-8194	LUAD	TCGA	AKTSS	DEG_SPOP_SBC_1	603:607	Mutation rewiring degron network	0.2222
p.Q599R	DO23971	LUAD	ICGC	AKTSS	DEG_SPOP_SBC_1	603:607	Mutation rewiring degron network	0.2222
p.P601Q	DO228952	LICA	ICGC	AKTSS	DEG_SPOP_SBC_1	603:607	Mutation rewiring degron network	0.2778
p.D528E	DO228976	LICA	ICGC	PPGY	ITCH	524:527	Mutation rewiring degron network	0.3056
p.A523E	DO229019	LICA	ICGC	PPGY	ITCH	524:527	Mutation rewiring degron network	0.3056
p.D517H	DO230934	LUSC	ICGC	PPGY	ITCH	524:527	Mutation rewiring degron network	0.1389
p.S534L	DO220899	MELA	ICGC	PPGY	ITCH	524:527	Mutation rewiring degron network	0.1389
p.D517N	DO229211	THCA	ICGC	PPGY	ITCH	524:527	Mutation rewiring degron network	0.1389
p.D517N	DO229234	THCA	ICGC	PPGY	ITCH	524:527	Mutation rewiring degron network	0.1389
p.A523T	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	PPGY	ITCH	524:527	Mutation rewiring degron network	0.3056
p.A523T	ACH-000929	Lung Cancer	CCLE	PPGY	ITCH	524:527	Mutation rewiring degron network	0.3056
p.A523T	NCI-H2110	lung	COSMIC	PPGY	ITCH	524:527	Mutation rewiring degron network	0.3056
p.T536A	SIDM01045	Endometrial Carcinoma	GDSC	PPGY	ITCH	524:527	Mutation rewiring degron network	0.0833
p.T536A	EN	endometrium	COSMIC	PPGY	ITCH	524:527	Mutation rewiring degron network	0.0833
p.H531R	ACH-001719	Ovarian Cancer	CCLE	PPGY	ITCH	524:527	Mutation rewiring degron network	0.2222

Kaplan plot for PARP4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PARP4

UniProt ID: Q9UKK3

Entrez ID: 143

Protein name: Protein mono-ADP-ribosyltransferase PARP4 (EC 2.4.2.-) (193 kDa vault protein) (ADP-ribosyltransferase diphtheria toxin-like 4) (ARTD4) (PARP-related/IalphaI-related H5/proline-rich) (PH5P) (Poly [ADP-ribose] polymerase 4) (PARP-4) (Vault poly(ADP-ribose) polymerase) (VPARP)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PARP4 in