DegronMD - Q9ULD9(ZNF608)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S1270G	TCGA-13-0768	OV	TCGA	PRKTPNKE	DEG_SCF_FBW7_2	1271:1278	Mutation rewiring degron network	0.3056
p.D1261H	TCGA-21-1081	LUSC	TCGA	PRKTPNKE	DEG_SCF_FBW7_2	1271:1278	Mutation rewiring degron network	0.0556
p.E1278D	TCGA-61-1733	OV	TCGA	PRKTPNKE	DEG_SCF_FBW7_2	1271:1278	Mutation altering degron motif	0.6758
p.S1287L	TCGA-A5-A0G2	UCEC	TCGA	PRKTPNKE	DEG_SCF_FBW7_2	1271:1278	Mutation rewiring degron network	0.0833
p.P937L	TCGA-AP-A051	UCEC	TCGA	AKTSS	DEG_SPOP_SBC_1	932:936	Mutation rewiring degron network	0.3056
p.P1285S	TCGA-AP-A1DV	UCEC	TCGA	PRKTPNKE	DEG_SCF_FBW7_2	1271:1278	Mutation rewiring degron network	0.1389
p.K1277I	TCGA-DA-A3F3	SKCM	TCGA	PRKTPNKE	DEG_SCF_FBW7_2	1271:1278	Mutation altering degron motif	0.642
p.P937Q	TCGA-EE-A2GH	SKCM	TCGA	AKTSS	DEG_SPOP_SBC_1	932:936	Mutation rewiring degron network	0.3056
p.A946S	TCGA-EE-A2MS	SKCM	TCGA	AKTSS	DEG_SPOP_SBC_1	932:936	Mutation rewiring degron network	0.0556
p.A946S	SIDM00614	Hepatocellular Carcinoma	GDSC	AKTSS	DEG_SPOP_SBC_1	932:936	Mutation rewiring degron network	0.0556
p.A946S	ACH-000848	Liver Cancer	CCLE	AKTSS	DEG_SPOP_SBC_1	932:936	Mutation rewiring degron network	0.0556
p.A946S	JHH-7	liver	COSMIC	AKTSS	DEG_SPOP_SBC_1	932:936	Mutation rewiring degron network	0.0556
p.Q924K	TCGA-ER-A2NH	SKCM	TCGA	AKTSS	DEG_SPOP_SBC_1	932:936	Mutation rewiring degron network	0.1111
p.P923L	DO20815	KIRP	ICGC	AKTSS	DEG_SPOP_SBC_1	932:936	Mutation rewiring degron network	0.0833
p.V938A	DO47150	RECA	ICGC	AKTSS	DEG_SPOP_SBC_1	932:936	Mutation rewiring degron network	0.2778
p.R936W	DO43755	UCEC	ICGC	AKTSS	DEG_SPOP_SBC_1	932:936	Mutation altering degron motif	0.8634
p.R936Q	DO42793	UCEC	ICGC	AKTSS	DEG_SPOP_SBC_1	932:936	Mutation altering degron motif	0.7329
p.V1281L	SIDM00273	Glioblastoma	GDSC	PRKTPNKE	DEG_SCF_FBW7_2	1271:1278	Mutation rewiring degron network	0.25
p.V1281L	ACH-000756	Brain Cancer	CCLE	PRKTPNKE	DEG_SCF_FBW7_2	1271:1278	Mutation rewiring degron network	0.25
p.V1281L	GI-1	central nervous system	COSMIC	PRKTPNKE	DEG_SCF_FBW7_2	1271:1278	Mutation rewiring degron network	0.25

Kaplan plot for ZNF608 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZNF608

UniProt ID: Q9ULD9

Entrez ID: 57507

Protein name: Zinc finger protein 608 (Renal carcinoma antigen NY-REN-36)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for ZNF608 in