DegronMD

Uniprot ID: Q9ULD9

Source protein: Zinc finger protein 608

Source gene: ZNF608

Class: DEG_SCF_FBW7_2

Location: 1271:1278

E3 ligase: FBXW7

DEGRON score: 0.9546

ASA_SCORE: 132.1

COIL: 0.957

CONS_SCORE: 0.4142

DSS_SCORE: 0.7211

HELIX: 0.0263

FCONS_SCORE: 0.9767

RIG_SCORE: 0.564

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1270G	TCGA-13-0768	OV	TCGA	PRKTPNKE	DEG_SCF_FBW7_2	0.3056
p.D1261H	TCGA-21-1081	LUSC	TCGA	PRKTPNKE	DEG_SCF_FBW7_2	0.0556
p.E1278D	TCGA-61-1733	OV	TCGA	PRKTPNKE	DEG_SCF_FBW7_2	0.6758
p.S1287L	TCGA-A5-A0G2	UCEC	TCGA	PRKTPNKE	DEG_SCF_FBW7_2	0.0833
p.P1285S	TCGA-AP-A1DV	UCEC	TCGA	PRKTPNKE	DEG_SCF_FBW7_2	0.1389
p.K1277I	TCGA-DA-A3F3	SKCM	TCGA	PRKTPNKE	DEG_SCF_FBW7_2	0.642
p.V1281L	SIDM00273	Glioblastoma	GDSC	PRKTPNKE	DEG_SCF_FBW7_2	0.25
p.V1281L	ACH-000756	Brain Cancer	CCLE	PRKTPNKE	DEG_SCF_FBW7_2	0.25
p.V1281L	GI-1	central_nervous_system	COSMIC	PRKTPNKE	DEG_SCF_FBW7_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9ULD9	Zinc finger protein 608	DEG_SCF_FBW7_2	1271:1278	PRKTPNKE	FBXW7	0.9546	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons