DegronMD - Q6PIL6(KCNIP4)

FUNCTION: Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates KCND2 channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner (PubMed:11847232, PubMed:18957440, PubMed:2... View more >>

GO - Biological processes (BP): protein localization to plasma membrane [GO:0072659]; regulation of potassium ion transmembrane transport [GO:1901379]

GO - Molecular function (MF): calcium ion binding [GO:0005509]; potassium channel activity [GO:0005267]; potassium channel regulator activity [GO:0015459]; voltage-gated ion channel activity [GO:0005244]

GO - Cellular component (CC): cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S49L	SIDM01588	Endometrial Carcinoma	GDSC	AKTSS	DEG_SPOP_SBC_1	46:50	Mutation altering degron motif	0.7667
p.S46R	SW1116	large intestine	COSMIC	AKTSS	DEG_SPOP_SBC_1	46:50	Mutation altering degron motif	0.7427
p.T48M	DO234459	ESAD	ICGC	AKTSS	DEG_SPOP_SBC_1	46:50	Mutation altering degron motif	0.7423
p.T48M	DO34696	PACA	ICGC	AKTSS	DEG_SPOP_SBC_1	46:50	Mutation altering degron motif	0.7423
p.A46T	TCGA-AJ-A2QK	UCEC	TCGA	AKTSS	DEG_SPOP_SBC_1	46:50	Mutation altering degron motif	0.7139
p.A46T	DO41301	UCEC	ICGC	AKTSS	DEG_SPOP_SBC_1	46:50	Mutation altering degron motif	0.7139
p.S50Y	DO52667	MALY	ICGC	AKTSS	DEG_SPOP_SBC_1	46:50	Mutation altering degron motif	0.712
p.T49S	SBC-5	lung	COSMIC	AKTSS	DEG_SPOP_SBC_1	46:50	Mutation altering degron motif	0.7116
p.V49I	CHL-1	skin	COSMIC	AKTSS	DEG_SPOP_SBC_1	46:50	Mutation altering degron motif	0.7076
p.S46G	22RV1	prostate	COSMIC	AKTSS	DEG_SPOP_SBC_1	46:50	Mutation altering degron motif	0.6993
p.L48F	COLO-792	skin	COSMIC	AKTSS	DEG_SPOP_SBC_1	46:50	Mutation altering degron motif	0.6981
p.A47V	SNU-81	large intestine	COSMIC	AKTSS	DEG_SPOP_SBC_1	46:50	Mutation altering degron motif	0.6936
p.P51S	TCGA-FW-A3R5	SKCM	TCGA	AKTSS	DEG_SPOP_SBC_1	46:50	Mutation rewiring degron network	0.3056
p.P51S	DO37406	SKCM	ICGC	AKTSS	DEG_SPOP_SBC_1	46:50	Mutation rewiring degron network	0.3056
p.V45I	ACH-001024	Skin Cancer	CCLE	AKTSS	DEG_SPOP_SBC_1	46:50	Mutation rewiring degron network	0.3056
p.V45I	ACH-001786	Colon/Colorectal Cancer	CCLE	AKTSS	DEG_SPOP_SBC_1	46:50	Mutation rewiring degron network	0.3056
p.V45I	CHL-1	skin	COSMIC	AKTSS	DEG_SPOP_SBC_1	46:50	Mutation rewiring degron network	0.3056
p.L52F	ACH-000968	Skin Cancer	CCLE	AKTSS	DEG_SPOP_SBC_1	46:50	Mutation rewiring degron network	0.2778
p.L52F	COLO-792	skin	COSMIC	AKTSS	DEG_SPOP_SBC_1	46:50	Mutation rewiring degron network	0.2778
p.K39R	SIDM00946	T-Lymphoblastic Leukemia	GDSC	AKTSS	DEG_SPOP_SBC_1	46:50	Mutation substituting flanking lysine	0.25

Showing 1 to 20 of 46 entries

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Kaplan plot for KCNIP4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KCNIP4

UniProt ID: Q6PIL6

Entrez ID: 80333

Protein name: Kv channel-interacting protein 4 (KChIP4) (A-type potassium channel modulatory protein 4) (Calsenilin-like protein) (Potassium channel-interacting protein 4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KCNIP4 in