DegronMD - Q6PIL6(KCNIP4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A46T	TCGA-AJ-A2QK	UCEC	TCGA	AKTSS	DEG_SPOP_SBC_1	46:50	Mutation altering degron motif	0.7139
p.A46T	DO41301	UCEC	ICGC	AKTSS	DEG_SPOP_SBC_1	46:50	Mutation altering degron motif	0.7139
p.M38I	TCGA-BA-5152	HNSC	TCGA	AKTSS	DEG_SPOP_SBC_1	46:50	Mutation rewiring degron network	0.1111
p.M38I	DO14393	HNSC	ICGC	AKTSS	DEG_SPOP_SBC_1	46:50	Mutation rewiring degron network	0.1111
p.D59N	TCGA-D3-A1QB	SKCM	TCGA	AKTSS	DEG_SPOP_SBC_1	46:50	Mutation rewiring degron network	0.0833
p.D59N	DO47573	SKCM	ICGC	AKTSS	DEG_SPOP_SBC_1	46:50	Mutation rewiring degron network	0.0833
p.E60K	TCGA-FR-A8YC	SKCM	TCGA	AKTSS	DEG_SPOP_SBC_1	46:50	Mutation rewiring degron network	0.0556
p.E60K	DO50301	SKCM	ICGC	AKTSS	DEG_SPOP_SBC_1	46:50	Mutation rewiring degron network	0.0556
p.P51S	TCGA-FW-A3R5	SKCM	TCGA	AKTSS	DEG_SPOP_SBC_1	46:50	Mutation rewiring degron network	0.3056
p.P51S	DO37406	SKCM	ICGC	AKTSS	DEG_SPOP_SBC_1	46:50	Mutation rewiring degron network	0.3056
p.T48M	DO234459	ESAD	ICGC	AKTSS	DEG_SPOP_SBC_1	46:50	Mutation altering degron motif	0.7423
p.T48M	DO34696	PACA	ICGC	AKTSS	DEG_SPOP_SBC_1	46:50	Mutation altering degron motif	0.7423
p.S50Y	DO52667	MALY	ICGC	AKTSS	DEG_SPOP_SBC_1	46:50	Mutation altering degron motif	0.712
p.P42S	DO219873	SKCA	ICGC	AKTSS	DEG_SPOP_SBC_1	46:50	Mutation rewiring degron network	0.2222
p.L37I	SIDM00227	Neuroblastoma	GDSC	AKTSS	DEG_SPOP_SBC_1	46:50	Mutation rewiring degron network	0.0833
p.L37I	ACH-001344	Neuroblastoma	CCLE	AKTSS	DEG_SPOP_SBC_1	46:50	Mutation rewiring degron network	0.0833
p.L37I	GI-ME-N	autonomic ganglia	COSMIC	AKTSS	DEG_SPOP_SBC_1	46:50	Mutation rewiring degron network	0.0833
p.K39R	SIDM00946	T-Lymphoblastic Leukemia	GDSC	AKTSS	DEG_SPOP_SBC_1	46:50	Mutation substituting flanking lysine	0.25
p.K39R	ACH-000981	Leukemia	CCLE	AKTSS	DEG_SPOP_SBC_1	46:50	Mutation substituting flanking lysine	0.25
p.K39R	DND-41	haematopoietic and lymphoid tissue	COSMIC	AKTSS	DEG_SPOP_SBC_1	46:50	Mutation substituting flanking lysine	0.25
p.S49L	SIDM01588	Endometrial Carcinoma	GDSC	AKTSS	DEG_SPOP_SBC_1	46:50	Mutation altering degron motif	0.7667
p.S59R	ACH-000489	Colon/Colorectal Cancer	CCLE	AKTSS	DEG_SPOP_SBC_1	46:50	Mutation rewiring degron network	0.0833
p.S59R	SW1116	large intestine	COSMIC	AKTSS	DEG_SPOP_SBC_1	46:50	Mutation rewiring degron network	0.0833
p.S59G	ACH-000956	Prostate Cancer	CCLE	AKTSS	DEG_SPOP_SBC_1	46:50	Mutation rewiring degron network	0.0833
p.S59G	22RV1	prostate	COSMIC	AKTSS	DEG_SPOP_SBC_1	46:50	Mutation rewiring degron network	0.0833
p.L52F	ACH-000968	Skin Cancer	CCLE	AKTSS	DEG_SPOP_SBC_1	46:50	Mutation rewiring degron network	0.2778
p.L52F	COLO-792	skin	COSMIC	AKTSS	DEG_SPOP_SBC_1	46:50	Mutation rewiring degron network	0.2778
p.A43V	ACH-000991	Colon/Colorectal Cancer	CCLE	AKTSS	DEG_SPOP_SBC_1	46:50	Mutation rewiring degron network	0.25
p.A43V	SNU-81	large intestine	COSMIC	AKTSS	DEG_SPOP_SBC_1	46:50	Mutation rewiring degron network	0.25
p.V45I	ACH-001024	Skin Cancer	CCLE	AKTSS	DEG_SPOP_SBC_1	46:50	Mutation rewiring degron network	0.3056
p.V45I	ACH-001786	Colon/Colorectal Cancer	CCLE	AKTSS	DEG_SPOP_SBC_1	46:50	Mutation rewiring degron network	0.3056
p.V45I	CHL-1	skin	COSMIC	AKTSS	DEG_SPOP_SBC_1	46:50	Mutation rewiring degron network	0.3056
p.A39V	SNU-81	large intestine	COSMIC	AKTSS	DEG_SPOP_SBC_1	46:50	Mutation substituting flanking lysine	0.25
p.T60A	P30-OHK	haematopoietic and lymphoid tissue	COSMIC	AKTSS	DEG_SPOP_SBC_1	46:50	Mutation rewiring degron network	0.0556
p.S55R	SW1116	large intestine	COSMIC	AKTSS	DEG_SPOP_SBC_1	46:50	Mutation rewiring degron network	0.1944
p.L56F	COLO-792	skin	COSMIC	AKTSS	DEG_SPOP_SBC_1	46:50	Mutation rewiring degron network	0.1667
p.V41I	CHL-1	skin	COSMIC	AKTSS	DEG_SPOP_SBC_1	46:50	Mutation rewiring degron network	0.1944
p.S55G	22RV1	prostate	COSMIC	AKTSS	DEG_SPOP_SBC_1	46:50	Mutation rewiring degron network	0.1944
p.T58S	SBC-5	lung	COSMIC	AKTSS	DEG_SPOP_SBC_1	46:50	Mutation rewiring degron network	0.1111
p.L39F	COLO-792	skin	COSMIC	AKTSS	DEG_SPOP_SBC_1	46:50	Mutation substituting flanking lysine	0.25
p.A47V	SNU-81	large intestine	COSMIC	AKTSS	DEG_SPOP_SBC_1	46:50	Mutation altering degron motif	0.6936
p.V49I	CHL-1	skin	COSMIC	AKTSS	DEG_SPOP_SBC_1	46:50	Mutation altering degron motif	0.7076
p.T49S	SBC-5	lung	COSMIC	AKTSS	DEG_SPOP_SBC_1	46:50	Mutation altering degron motif	0.7116
p.S46G	22RV1	prostate	COSMIC	AKTSS	DEG_SPOP_SBC_1	46:50	Mutation altering degron motif	0.6993
p.S46R	SW1116	large intestine	COSMIC	AKTSS	DEG_SPOP_SBC_1	46:50	Mutation altering degron motif	0.7427
p.L48F	COLO-792	skin	COSMIC	AKTSS	DEG_SPOP_SBC_1	46:50	Mutation altering degron motif	0.6981

Kaplan plot for KCNIP4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KCNIP4

UniProt ID: Q6PIL6

Entrez ID: 80333

Protein name: Kv channel-interacting protein 4 (KChIP4) (A-type potassium channel modulatory protein 4) (Calsenilin-like protein) (Potassium channel-interacting protein 4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KCNIP4 in