DegronMD

Uniprot ID: P49023

Source protein: Paxillin

Source gene: PXN

Class: DEG_COP1_1

Location: 222:231

E3 ligase: COP1

DEGRON score: 0.9864

ASA_SCORE: 90.41

COIL: 0.7086

CONS_SCORE: 0.3187

DSS_SCORE: 0.5554

HELIX: 0.2806

FCONS_SCORE: 1.0409

RIG_SCORE: 0.6684

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S227F	TCGA-06-5416	GBM	TCGA	DELESSVPSP	DEG_COP1_1	0.6871
p.S227F	TCGA-XF-A9T0	BLCA	TCGA	DELESSVPSP	DEG_COP1_1	0.6871
p.E241D	TCGA-24-2289	OV	TCGA	DELESSVPSP	DEG_COP1_1	0.0556
p.V237A	TCGA-FI-A2D5	UCEC	TCGA	DELESSVPSP	DEG_COP1_1	0.1667
p.L218V	DO225354	BRCA	ICGC	DELESSVPSP	DEG_COP1_1	0.2222
p.H214Q	DO219745	CESC	ICGC	DELESSVPSP	DEG_COP1_1	0.1111
p.V216A	DO51734	COAD	ICGC	DELESSVPSP	DEG_COP1_1	0.1667
p.G225E	DO222727	MELA	ICGC	DELESSVPSP	DEG_COP1_1	0.7199
p.G225E	DO38028	SKCM	ICGC	DELESSVPSP	DEG_COP1_1	0.7199
p.E239D	DO30210	OV	ICGC	DELESSVPSP	DEG_COP1_1	0.1111
p.K240E	DO29940	OV	ICGC	DELESSVPSP	DEG_COP1_1	0.0833
p.F230L	DO28373	OV	ICGC	DELESSVPSP	DEG_COP1_1	0.6981
p.R212W	DO232761	PBCA	ICGC	DELESSVPSP	DEG_COP1_1	0.0556
p.S226T	DO38123	SKCM	ICGC	DELESSVPSP	DEG_COP1_1	0.6005
p.V235A	DO41331	UCEC	ICGC	DELESSVPSP	DEG_COP1_1	0.2222
p.G240C	SIDM00946	T-Lymphoblastic Leukemia	GDSC	DELESSVPSP	DEG_COP1_1	0.0833
p.V232I	SIDM00962	Chronic Myelogenous Leukemia	GDSC	DELESSVPSP	DEG_COP1_1	0.3056
p.E241K	SIDM00997	Thyroid Gland Carcinoma	GDSC	DELESSVPSP	DEG_COP1_1	0.0556
p.E241K	ACH-000862	Bladder Cancer	CCLE	DELESSVPSP	DEG_COP1_1	0.0556
p.E241K	ACH-001306	Thyroid Cancer	CCLE	DELESSVPSP	DEG_COP1_1	0.0556
p.R214Q	SIDM00150	Colorectal Carcinoma	GDSC	DELESSVPSP	DEG_COP1_1	0.1111
p.R214Q	KM12	large_intestine	COSMIC	DELESSVPSP	DEG_COP1_1	0.1111
p.P231L	ACH-000690	Lung Cancer	CCLE	DELESSVPSP	DEG_COP1_1	0.6471
p.V237M	ACH-000954	Endometrial/Uterine Cancer	CCLE	DELESSVPSP	DEG_COP1_1	0.1667
p.R212Q	ACH-000969	Colon/Colorectal Cancer	CCLE	DELESSVPSP	DEG_COP1_1	0.0556
p.R212Q	KM12	large_intestine	COSMIC	DELESSVPSP	DEG_COP1_1	0.0556
p.F229L	EN	endometrium	COSMIC	DELESSVPSP	DEG_COP1_1	0.6981

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P49023	Paxillin	DEG_COP1_1	222:231	DELESSVPSP	COP1	0.9864	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DELESSVPSP

Degron related mutations and impact score

Drug responses associated with PXN mutations

All proteins holding degron of DELESSVPSP