DegronMD

Uniprot ID: O75928

Source protein: E3 SUMO-protein ligase PIAS2

Source gene: PIAS2

Class: DEG_SPOP_SBC_1

Location: 606:610

E3 ligase: SPOP

DEGRON score: 0.5785

ASA_SCORE: 83.42

COIL: 0.8856

CONS_SCORE: 0.2939

DSS_SCORE: 0.5331

HELIX: 0.017

FCONS_SCORE: 1.0468

RIG_SCORE: 0.6612

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S602T	TCGA-B6-A0RG	BRCA	TCGA	VITSS	DEG_SPOP_SBC_1	0.2222
p.S602T	DO2353	BRCA	ICGC	VITSS	DEG_SPOP_SBC_1	0.2222
p.G605W	TCGA-H4-A2HO	BLCA	TCGA	VITSS	DEG_SPOP_SBC_1	0.3056
p.G605W	DO494	BLCA	ICGC	VITSS	DEG_SPOP_SBC_1	0.3056
p.I614T	TCGA-HU-A4GT	STAD	TCGA	VITSS	DEG_SPOP_SBC_1	0.2222
p.I614T	DO48020	STAD	ICGC	VITSS	DEG_SPOP_SBC_1	0.2222
p.P615S	SIDM00545	Melanoma	GDSC	VITSS	DEG_SPOP_SBC_1	0.1944
p.P615S	ACH-000987	Skin Cancer	CCLE	VITSS	DEG_SPOP_SBC_1	0.1944
p.P615S	Mewo	skin	COSMIC	VITSS	DEG_SPOP_SBC_1	0.1944
p.S612R	SIDM00845	Burkitt's Lymphoma	GDSC	VITSS	DEG_SPOP_SBC_1	0.2778
p.S612R	SIDM00461	Acute Myeloid Leukemia	GDSC	VITSS	DEG_SPOP_SBC_1	0.2778
p.S612R	SIDM00946	T-Lymphoblastic Leukemia	GDSC	VITSS	DEG_SPOP_SBC_1	0.2778
p.S612R	SIDM01519	Head and Neck Carcinoma	GDSC	VITSS	DEG_SPOP_SBC_1	0.2778
p.S612R	ACH-000786	Lymphoma	CCLE	VITSS	DEG_SPOP_SBC_1	0.2778
p.S612R	ACH-000992	Head and Neck Cancer	CCLE	VITSS	DEG_SPOP_SBC_1	0.2778
p.S612R	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	VITSS	DEG_SPOP_SBC_1	0.2778
p.S600T	ACH-001852	Bile Duct Cancer	CCLE	VITSS	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00764	Pyridoxal kinase	DEG_SPOP_SBC_1	184:188	VITSS	SPOP	0.6795	More...
O75928	E3 SUMO-protein ligase PIAS2	DEG_SPOP_SBC_1	606:610	VITSS	SPOP	0.5785	More...
O95677	Eyes absent homolog 4	DEG_SPOP_SBC_1	124:128	VITSS	SPOP	0.9997	More...
P28324	ETS domain-containing protein Elk-4	DEG_SPOP_SBC_1	332:336	VITSS	SPOP	0.9963	More...
Q6GYQ0	Ral GTPase-activating protein subunit alpha-1	DEG_SPOP_SBC_1	456:460	VITSS	SPOP	0.9959	More...
Q6WRI0	Immunoglobulin superfamily member 10	DEG_SPOP_SBC_1	1176:1180	VITSS	SPOP	0.918	More...
Q8IZD4	mRNA-decapping enzyme 1B	DEG_SPOP_SBC_1	571:575	VITSS	SPOP	0.9737	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	5819:5823	VITSS	SPOP	0.9816	More...
Q9Y467	Sal-like protein 2	DEG_SPOP_SBC_1	444:448	VITSS	SPOP	0.9233	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons