DegronMD

Uniprot ID: Q9Y467

Source protein: Sal-like protein 2

Source gene: SALL2

Class: DEG_SPOP_SBC_1

Location: 444:448

E3 ligase: SPOP

DEGRON score: 0.9233

ASA_SCORE: 64.84

COIL: 0.7204

CONS_SCORE: 0.4018

DSS_SCORE: 0.4271

HELIX: 0.0692

FCONS_SCORE: 0.8498

RIG_SCORE: 0.7468

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D442H	TCGA-92-8065	LUSC	TCGA	VITSS	DEG_SPOP_SBC_1	0.2778
p.V456M	TCGA-AP-A059	UCEC	TCGA	VITSS	DEG_SPOP_SBC_1	0.1111
p.S455Y	TCGA-CN-4738	HNSC	TCGA	VITSS	DEG_SPOP_SBC_1	0.1389
p.V444L	TCGA-E7-A541	BLCA	TCGA	VITSS	DEG_SPOP_SBC_1	0.6765
p.P434L	TCGA-EE-A3J5	SKCM	TCGA	VITSS	DEG_SPOP_SBC_1	0.0556
p.E451G	DO50319	ESAD	ICGC	VITSS	DEG_SPOP_SBC_1	0.25
p.T452K	DO229025	LICA	ICGC	VITSS	DEG_SPOP_SBC_1	0.2222
p.Y443C	SIDM00537	Colorectal Carcinoma	GDSC	VITSS	DEG_SPOP_SBC_1	0.3056
p.Y443C	ACH-000982	Colon/Colorectal Cancer	CCLE	VITSS	DEG_SPOP_SBC_1	0.3056
p.Y443C	ACH-001345	Colon/Colorectal Cancer	CCLE	VITSS	DEG_SPOP_SBC_1	0.3056
p.Y443C	GP5d	large_intestine	COSMIC	VITSS	DEG_SPOP_SBC_1	0.3056
p.P439S	MCC13	skin	COSMIC	VITSS	DEG_SPOP_SBC_1	0.1944
p.P444S	CW-2	large_intestine	COSMIC	VITSS	DEG_SPOP_SBC_1	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00764	Pyridoxal kinase	DEG_SPOP_SBC_1	184:188	VITSS	SPOP	0.6795	More...
O75928	E3 SUMO-protein ligase PIAS2	DEG_SPOP_SBC_1	606:610	VITSS	SPOP	0.5785	More...
O95677	Eyes absent homolog 4	DEG_SPOP_SBC_1	124:128	VITSS	SPOP	0.9997	More...
P28324	ETS domain-containing protein Elk-4	DEG_SPOP_SBC_1	332:336	VITSS	SPOP	0.9963	More...
Q6GYQ0	Ral GTPase-activating protein subunit alpha-1	DEG_SPOP_SBC_1	456:460	VITSS	SPOP	0.9959	More...
Q6WRI0	Immunoglobulin superfamily member 10	DEG_SPOP_SBC_1	1176:1180	VITSS	SPOP	0.918	More...
Q8IZD4	mRNA-decapping enzyme 1B	DEG_SPOP_SBC_1	571:575	VITSS	SPOP	0.9737	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	5819:5823	VITSS	SPOP	0.9816	More...
Q9Y467	Sal-like protein 2	DEG_SPOP_SBC_1	444:448	VITSS	SPOP	0.9233	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons