DegronMD - O00764(PDXK)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D181N	TCGA-AP-A0LM	UCEC	TCGA	VITSS	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.25
p.D181N	DO43306	UCEC	ICGC	VITSS	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.25
p.S188F	TCGA-UC-A7PG	CESC	TCGA	VITSS	DEG_SPOP_SBC_1	184:188	Mutation altering degron motif	0.7982
p.T182I	TCGA-XK-AAIW	PRAD	TCGA	VITSS	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.2778
p.T182I	DO51407	PRAD	ICGC	VITSS	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.2778
p.V186L	DO229026	LICA	ICGC	VITSS	DEG_SPOP_SBC_1	184:188	Mutation altering degron motif	0.6765
p.R178H	DO42177	UCEC	ICGC	VITSS	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.1667
p.R178H	SK-UT-1	soft tissue	COSMIC	VITSS	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.1667
p.V189I	SNU-C2B	large intestine	COSMIC	VITSS	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.3056
p.R190H	SK-UT-1	soft tissue	COSMIC	VITSS	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.2778

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons