DegronMD - O75928(PIAS2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S519L	TCGA-61-1722	OV	TCGA	SSVRVPSV	DEG_COP1_1	510:517	Mutation rewiring degron network	0.2778
p.S519L	TCGA-AA-3984	COAD	TCGA	SSVRVPSV	DEG_COP1_1	510:517	Mutation rewiring degron network	0.2778
p.S519L	TCGA-AX-A05Z	UCEC	TCGA	SSVRVPSV	DEG_COP1_1	510:517	Mutation rewiring degron network	0.2778
p.S519L	TCGA-CA-6718	COAD	TCGA	SSVRVPSV	DEG_COP1_1	510:517	Mutation rewiring degron network	0.2778
p.S519L	DO9002	COAD	ICGC	SSVRVPSV	DEG_COP1_1	510:517	Mutation rewiring degron network	0.2778
p.S519L	DO7801	COAD	ICGC	SSVRVPSV	DEG_COP1_1	510:517	Mutation rewiring degron network	0.2778
p.S519L	DO8898	COAD	ICGC	SSVRVPSV	DEG_COP1_1	510:517	Mutation rewiring degron network	0.2778
p.S519L	DO31190	OV	ICGC	SSVRVPSV	DEG_COP1_1	510:517	Mutation rewiring degron network	0.2778
p.S519L	DO40884	UCEC	ICGC	SSVRVPSV	DEG_COP1_1	510:517	Mutation rewiring degron network	0.2778
p.S519L	SIDM01611	Endometrial Carcinoma	GDSC	SSVRVPSV	DEG_COP1_1	510:517	Mutation rewiring degron network	0.2778
p.S519L	ACH-000996	Endometrial/Uterine Cancer	CCLE	SSVRVPSV	DEG_COP1_1	510:517	Mutation rewiring degron network	0.2778
p.S602T	TCGA-B6-A0RG	BRCA	TCGA	VSSSS	DEG_SPOP_SBC_1	595:599	Mutation rewiring degron network	0.25
p.S602T	TCGA-B6-A0RG	BRCA	TCGA	VITSS	DEG_SPOP_SBC_1	606:610	Mutation rewiring degron network	0.2222
p.S602T	DO2353	BRCA	ICGC	VSSSS	DEG_SPOP_SBC_1	595:599	Mutation rewiring degron network	0.25
p.S602T	DO2353	BRCA	ICGC	VITSS	DEG_SPOP_SBC_1	606:610	Mutation rewiring degron network	0.2222
p.S599I	TCGA-BR-8372	STAD	TCGA	VSSSS	DEG_SPOP_SBC_1	595:599	Mutation altering degron motif	0.7341
p.S599I	DO47873	STAD	ICGC	VSSSS	DEG_SPOP_SBC_1	595:599	Mutation altering degron motif	0.7341
p.M506V	TCGA-CG-4460	STAD	TCGA	SSVRVPSV	DEG_COP1_1	510:517	Mutation rewiring degron network	0.2222
p.M506V	DO38427	STAD	ICGC	SSVRVPSV	DEG_COP1_1	510:517	Mutation rewiring degron network	0.2222
p.V504I	TCGA-FI-A2D0	UCEC	TCGA	SSVRVPSV	DEG_COP1_1	510:517	Mutation rewiring degron network	0.1667
p.V504I	DO43891	UCEC	ICGC	SSVRVPSV	DEG_COP1_1	510:517	Mutation rewiring degron network	0.1667
p.G605W	TCGA-H4-A2HO	BLCA	TCGA	VSSSS	DEG_SPOP_SBC_1	595:599	Mutation rewiring degron network	0.1667
p.G605W	TCGA-H4-A2HO	BLCA	TCGA	VITSS	DEG_SPOP_SBC_1	606:610	Mutation rewiring degron network	0.3056
p.G605W	DO494	BLCA	ICGC	VSSSS	DEG_SPOP_SBC_1	595:599	Mutation rewiring degron network	0.1667
p.G605W	DO494	BLCA	ICGC	VITSS	DEG_SPOP_SBC_1	606:610	Mutation rewiring degron network	0.3056
p.S587G	TCGA-HF-7132	STAD	TCGA	ASSTS	DEG_SPOP_SBC_1	578:582	Mutation rewiring degron network	0.1944
p.S587G	TCGA-HF-7132	STAD	TCGA	VSSSS	DEG_SPOP_SBC_1	595:599	Mutation rewiring degron network	0.1111
p.S587G	DO38214	STAD	ICGC	ASSTS	DEG_SPOP_SBC_1	578:582	Mutation rewiring degron network	0.1944
p.S587G	DO38214	STAD	ICGC	VSSSS	DEG_SPOP_SBC_1	595:599	Mutation rewiring degron network	0.1111
p.I614T	TCGA-HU-A4GT	STAD	TCGA	VITSS	DEG_SPOP_SBC_1	606:610	Mutation rewiring degron network	0.2222
p.I614T	DO48020	STAD	ICGC	VITSS	DEG_SPOP_SBC_1	606:610	Mutation rewiring degron network	0.2222
p.D570Y	DO224930	BRCA	ICGC	ASSTS	DEG_SPOP_SBC_1	578:582	Mutation rewiring degron network	0.1111
p.D570Y	DO227809	BRCA	ICGC	ASSTS	DEG_SPOP_SBC_1	578:582	Mutation rewiring degron network	0.1111
p.P509T	DO229035	LICA	ICGC	SSVRVPSV	DEG_COP1_1	510:517	Mutation rewiring degron network	0.3056
p.P575T	DO229041	LICA	ICGC	ASSTS	DEG_SPOP_SBC_1	578:582	Mutation rewiring degron network	0.25
p.V514M	DO229050	LICA	ICGC	SSVRVPSV	DEG_COP1_1	510:517	Mutation altering degron motif	0.7208
p.S588F	DO222653	MELA	ICGC	ASSTS	DEG_SPOP_SBC_1	578:582	Mutation rewiring degron network	0.1667
p.S588F	DO222653	MELA	ICGC	VSSSS	DEG_SPOP_SBC_1	595:599	Mutation rewiring degron network	0.1389
p.S588P	DO233468	PRAD	ICGC	ASSTS	DEG_SPOP_SBC_1	578:582	Mutation rewiring degron network	0.1667
p.S588P	DO233468	PRAD	ICGC	VSSSS	DEG_SPOP_SBC_1	595:599	Mutation rewiring degron network	0.1389
p.S588P	ACH-000786	Lymphoma	CCLE	ASSTS	DEG_SPOP_SBC_1	578:582	Mutation rewiring degron network	0.1667
p.S588P	ACH-000786	Lymphoma	CCLE	VSSSS	DEG_SPOP_SBC_1	595:599	Mutation rewiring degron network	0.1389
p.S588P	ACH-000992	Head and Neck Cancer	CCLE	ASSTS	DEG_SPOP_SBC_1	578:582	Mutation rewiring degron network	0.1667
p.S588P	ACH-000992	Head and Neck Cancer	CCLE	VSSSS	DEG_SPOP_SBC_1	595:599	Mutation rewiring degron network	0.1389
p.S588P	ACH-001067	Brain Cancer	CCLE	ASSTS	DEG_SPOP_SBC_1	578:582	Mutation rewiring degron network	0.1667
p.S588P	ACH-001067	Brain Cancer	CCLE	VSSSS	DEG_SPOP_SBC_1	595:599	Mutation rewiring degron network	0.1389
p.S588P	Daudi	haematopoietic and lymphoid tissue	COSMIC	ASSTS	DEG_SPOP_SBC_1	578:582	Mutation rewiring degron network	0.1667
p.S588P	Daudi	haematopoietic and lymphoid tissue	COSMIC	VSSSS	DEG_SPOP_SBC_1	595:599	Mutation rewiring degron network	0.1389
p.S588P	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	ASSTS	DEG_SPOP_SBC_1	578:582	Mutation rewiring degron network	0.1667
p.S588P	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	VSSSS	DEG_SPOP_SBC_1	595:599	Mutation rewiring degron network	0.1389
p.S510P	DO228741	PRAD	ICGC	SSVRVPSV	DEG_COP1_1	510:517	Mutation altering degron motif	0.6752
p.S591I	DO229211	THCA	ICGC	ASSTS	DEG_SPOP_SBC_1	578:582	Mutation rewiring degron network	0.0833
p.S591I	DO229211	THCA	ICGC	VSSSS	DEG_SPOP_SBC_1	595:599	Mutation rewiring degron network	0.2222
p.T569N	DO42312	UCEC	ICGC	ASSTS	DEG_SPOP_SBC_1	578:582	Mutation rewiring degron network	0.0833
p.P526L	SIDM00216	Colorectal Carcinoma	GDSC	SSVRVPSV	DEG_COP1_1	510:517	Mutation rewiring degron network	0.0833
p.P526L	ACH-000989	Colon/Colorectal Cancer	CCLE	SSVRVPSV	DEG_COP1_1	510:517	Mutation rewiring degron network	0.0833
p.P526L	SNU-175	large intestine	COSMIC	SSVRVPSV	DEG_COP1_1	510:517	Mutation rewiring degron network	0.0833
p.P615S	SIDM00545	Melanoma	GDSC	VITSS	DEG_SPOP_SBC_1	606:610	Mutation rewiring degron network	0.1944
p.P615S	ACH-000987	Skin Cancer	CCLE	VITSS	DEG_SPOP_SBC_1	606:610	Mutation rewiring degron network	0.1944
p.P615S	Mewo	skin	COSMIC	VITSS	DEG_SPOP_SBC_1	606:610	Mutation rewiring degron network	0.1944
p.S612R	SIDM00845	Burkitt's Lymphoma	GDSC	VITSS	DEG_SPOP_SBC_1	606:610	Mutation rewiring degron network	0.2778
p.S612R	SIDM00461	Acute Myeloid Leukemia	GDSC	VITSS	DEG_SPOP_SBC_1	606:610	Mutation rewiring degron network	0.2778
p.S612R	SIDM00946	T-Lymphoblastic Leukemia	GDSC	VITSS	DEG_SPOP_SBC_1	606:610	Mutation rewiring degron network	0.2778
p.S612R	SIDM01519	Head and Neck Carcinoma	GDSC	VITSS	DEG_SPOP_SBC_1	606:610	Mutation rewiring degron network	0.2778
p.S612R	ACH-000786	Lymphoma	CCLE	VITSS	DEG_SPOP_SBC_1	606:610	Mutation rewiring degron network	0.2778
p.S612R	ACH-000992	Head and Neck Cancer	CCLE	VITSS	DEG_SPOP_SBC_1	606:610	Mutation rewiring degron network	0.2778
p.S612R	Daudi	haematopoietic and lymphoid tissue	COSMIC	VITSS	DEG_SPOP_SBC_1	606:610	Mutation rewiring degron network	0.2778
p.D570G	SIDM00845	Burkitt's Lymphoma	GDSC	ASSTS	DEG_SPOP_SBC_1	578:582	Mutation rewiring degron network	0.1111
p.S596I	SIDM01986	Non-Small Cell Lung Carcinoma	GDSC	VSSSS	DEG_SPOP_SBC_1	595:599	Mutation altering degron motif	0.623
p.S596I	SIDM00903	Non-Small Cell Lung Carcinoma	GDSC	VSSSS	DEG_SPOP_SBC_1	595:599	Mutation altering degron motif	0.623
p.S596I	SIDM00902	Non-Small Cell Lung Carcinoma	GDSC	VSSSS	DEG_SPOP_SBC_1	595:599	Mutation altering degron motif	0.623
p.S596I	ACH-000681	Lung Cancer	CCLE	VSSSS	DEG_SPOP_SBC_1	595:599	Mutation altering degron motif	0.623
p.S596I	ACH-002337	Lung Cancer	CCLE	VSSSS	DEG_SPOP_SBC_1	595:599	Mutation altering degron motif	0.623
p.S596I	A549	lung	COSMIC	VSSSS	DEG_SPOP_SBC_1	595:599	Mutation altering degron motif	0.623
p.S600T	ACH-001852	Bile Duct Cancer	CCLE	VSSSS	DEG_SPOP_SBC_1	595:599	Mutation rewiring degron network	0.3056
p.S600T	ACH-001852	Bile Duct Cancer	CCLE	VITSS	DEG_SPOP_SBC_1	606:610	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PIAS2

UniProt ID: O75928

Entrez ID: 9063

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PIAS2 in