DegronMD

Uniprot ID: O75928

Source protein: E3 SUMO-protein ligase PIAS2

Source gene: PIAS2

Class: DEG_COP1_1

Location: 510:517

E3 ligase: COP1

DEGRON score: 0.9953

ASA_SCORE: 91.7875

COIL: 0.9558

CONS_SCORE: 0.3196

DSS_SCORE: 0.3854

HELIX: 0.019

FCONS_SCORE: 1.0155

RIG_SCORE: 0.7168

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S519L	TCGA-61-1722	OV	TCGA	SSVRVPSV	DEG_COP1_1	0.2778
p.S519L	TCGA-AA-3984	COAD	TCGA	SSVRVPSV	DEG_COP1_1	0.2778
p.S519L	TCGA-AX-A05Z	UCEC	TCGA	SSVRVPSV	DEG_COP1_1	0.2778
p.S519L	TCGA-CA-6718	COAD	TCGA	SSVRVPSV	DEG_COP1_1	0.2778
p.S519L	DO9002	COAD	ICGC	SSVRVPSV	DEG_COP1_1	0.2778
p.S519L	DO7801	COAD	ICGC	SSVRVPSV	DEG_COP1_1	0.2778
p.S519L	DO8898	COAD	ICGC	SSVRVPSV	DEG_COP1_1	0.2778
p.S519L	DO31190	OV	ICGC	SSVRVPSV	DEG_COP1_1	0.2778
p.S519L	DO40884	UCEC	ICGC	SSVRVPSV	DEG_COP1_1	0.2778
p.S519L	SIDM01611	Endometrial Carcinoma	GDSC	SSVRVPSV	DEG_COP1_1	0.2778
p.S519L	ACH-000996	Endometrial/Uterine Cancer	CCLE	SSVRVPSV	DEG_COP1_1	0.2778
p.M506V	TCGA-CG-4460	STAD	TCGA	SSVRVPSV	DEG_COP1_1	0.2222
p.M506V	DO38427	STAD	ICGC	SSVRVPSV	DEG_COP1_1	0.2222
p.V504I	TCGA-FI-A2D0	UCEC	TCGA	SSVRVPSV	DEG_COP1_1	0.1667
p.V504I	DO43891	UCEC	ICGC	SSVRVPSV	DEG_COP1_1	0.1667
p.P509T	DO229035	LICA	ICGC	SSVRVPSV	DEG_COP1_1	0.3056
p.V514M	DO229050	LICA	ICGC	SSVRVPSV	DEG_COP1_1	0.7208
p.S510P	DO228741	PRAD	ICGC	SSVRVPSV	DEG_COP1_1	0.6752
p.P526L	SIDM00216	Colorectal Carcinoma	GDSC	SSVRVPSV	DEG_COP1_1	0.0833
p.P526L	ACH-000989	Colon/Colorectal Cancer	CCLE	SSVRVPSV	DEG_COP1_1	0.0833
p.P526L	SNU-175	large_intestine	COSMIC	SSVRVPSV	DEG_COP1_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75928	E3 SUMO-protein ligase PIAS2	DEG_COP1_1	510:517	SSVRVPSV	COP1	0.9953	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons